Gene/Proteome Database (LMPD)

LMPD ID
LMP002059
Gene ID
17117
Species
Mus musculus (Mouse)
Gene Name
alpha-methylacyl-CoA racemase
Gene Symbol
Amacr
Synonyms
Macr1
Alternate Names
alpha-methylacyl-CoA racemase; 2-methylacyl-CoA racemase; 2-arylpropionyl-CoA epimerase; alpha-methylacyl-Coenzyme A racemase
Chromosome
15
Map Location
15|15 B1
EC Number
5.1.99.4

Proteins

alpha-methylacyl-CoA racemase
Refseq ID NP_032563
Protein GI 46518506
UniProt ID O09174
mRNA ID NM_008537
Length 381
RefSeq Status PROVISIONAL
MVLRGVRVVELAGLAPGPFCGMVLADFGAEVVRVNRLGSTGENFLARGKRSLALDLKRSQGVTVLRRMCARADVLLEPFRCGVMEKLQLGPETLLQDNPKLIYARLSGFGQSGIFSKVAGHDINYLALSGVLSKIGRSGENPYPPLNLLADFGGGGLMCTLGIVLALFERTRSGRGQVIDSSMVEGTAYLSSFLWKTQPMGLWKQPRGQNILDGGAPFYTTYKTADGEFMAVGAIEPQFYALLLKGLGLESEELPSQMSSADWPEMKKKFADVFAKKTKAEWCQIFDGTDACVTPVLTFEEALHHQHNRERASFITDGEQLPSPRPAPLLSRTPAVPSAKRDPSVGEHTVEVLREYGFSQEEILQLHSDRIVESDKLKANL

Gene Information

Entrez Gene ID
17117
Gene Name
alpha-methylacyl-CoA racemase
Gene Symbol
Amacr
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:MGI C mitochondrion
GO:0005777 IEA:UniProtKB-KW C peroxisome
GO:0008111 TAS:MGI F alpha-methylacyl-CoA racemase activity
GO:0006699 IEA:UniProtKB-UniPathway P bile acid biosynthetic process
GO:0006631 IEA:UniProtKB-UniPathway P fatty acid metabolic process
GO:0008300 TAS:MGI P isoprenoid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04146 Peroxisome
mmu00120 Primary bile acid biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5893443 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
5893441 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

Domain Information

InterPro Annotations

Accession Description
IPR003673 CoA-transferase family III
IPR023606 CoA-transferase family III domain

UniProt Annotations

Entry Information

Gene Name
alpha-methylacyl-CoA racemase
Protein Entry
AMACR_MOUSE
UniProt ID
O09174
Species
Mouse

Comments

Comment Type Description
Catalytic Activity (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA.
Function Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.
Pathway Lipid metabolism; bile acid biosynthesis.
Pathway Lipid metabolism; fatty acid metabolism.
Sequence Caution Sequence=AAB72146.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity Belongs to the CaiB/BaiF CoA-transferase family. {ECO:0000305}.
Subcellular Location Peroxisome {ECO:0000269|PubMed:10770938}. Mitochondrion {ECO:0000269|PubMed:10770938}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002059 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
46518506 RefSeq NP_032563 381 alpha-methylacyl-CoA racemase

Identical Sequences to LMP002059 proteins

Reference Database Accession Length Protein Name
GI:46518506 DBBJ BAC33284.1 381 unnamed protein product [Mus musculus]
GI:46518506 DBBJ BAB22072.2 381 unnamed protein product [Mus musculus]
GI:46518506 SwissProt O09174.4 381 RecName: Full=Alpha-methylacyl-CoA racemase; AltName: Full=2-methylacyl-CoA racemase [Mus musculus]

Related Sequences to LMP002059 proteins

Reference Database Accession Length Protein Name
GI:46518506 DBBJ BAE35893.1 381 unnamed protein product [Mus musculus]
GI:46518506 GenBank AAB72146.1 360 alpha-methylacyl-CoA racemase [Mus musculus]
GI:46518506 GenBank AAH15825.1 360 Amacr protein [Mus musculus]
GI:46518506 GenBank EDL03288.1 369 alpha-methylacyl-CoA racemase [Mus musculus]
GI:46518506 GenBank EDL82982.1 382 alpha-methylacyl-CoA racemase [Rattus norvegicus]
GI:46518506 RefSeq NP_036948.2 382 alpha-methylacyl-CoA racemase [Rattus norvegicus]