Gene/Proteome Database (LMPD)
LMPD ID
LMP002064
Gene ID
Species
Homo sapiens (Human)
Gene Name
prostaglandin E synthase
Gene Symbol
Synonyms
MGST-IV; MGST1-L1; MGST1L1; MPGES; PGES; PIG12; PP102; PP1294; TP53I12; mPGES-1
Alternate Names
prostaglandin E synthase; MGST1-like 1; p53-induced gene 12 protein; p53-induced apoptosis protein 12; glutathione S-transferase 1-like 1; microsomal prostaglandin E synthase 1; microsomal prostaglandin E synthase-1; tumor protein p53 inducible protein 12; microsomal glutathione S-transferase 1-like 1
Chromosome
9
Map Location
9q34.3
EC Number
5.3.99.3
Summary
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005789 | TAS:Reactome | C | endoplasmic reticulum membrane |
| GO:0016021 | IDA:UniProtKB | C | integral component of membrane |
| GO:0016020 | TAS:ProtInc | C | membrane |
| GO:0005641 | IEA:Ensembl | C | nuclear envelope lumen |
| GO:0048471 | IEA:Ensembl | C | perinuclear region of cytoplasm |
| GO:0043295 | IDA:UniProtKB | F | glutathione binding |
| GO:0050220 | IDA:UniProtKB | F | prostaglandin-E synthase activity |
| GO:0002526 | IEA:Ensembl | P | acute inflammatory response |
| GO:0019369 | TAS:Reactome | P | arachidonic acid metabolic process |
| GO:0002544 | IEA:Ensembl | P | chronic inflammatory response |
| GO:0019371 | TAS:Reactome | P | cyclooxygenase pathway |
| GO:0008285 | IEA:Ensembl | P | negative regulation of cell proliferation |
| GO:0001516 | IDA:UniProtKB | P | prostaglandin biosynthetic process |
| GO:0006693 | TAS:ProtInc | P | prostaglandin metabolic process |
| GO:0051592 | IEA:Ensembl | P | response to calcium ion |
| GO:0034097 | IEA:Ensembl | P | response to cytokine |
| GO:0032496 | IEA:Ensembl | P | response to lipopolysaccharide |
| GO:0014070 | IEA:Ensembl | P | response to organic cyclic compound |
| GO:0032526 | IEA:Ensembl | P | response to retinoic acid |
| GO:0007165 | NAS:ProtInc | P | signal transduction |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa00590 | Arachidonic acid metabolism |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_147851 | Arachidonic acid metabolism |
| REACT_150149 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15- hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15- dihydroxy-9-oxoprosta-5,13-dienoate. |
| Cofactor | Name=glutathione; Xref=ChEBI |
| Function | Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). |
| Induction | By p53/TP53. |
| Similarity | Belongs to the MAPEG family. |
| Subcellular Location | Membrane ; Multi-pass membrane protein . |
| Subunit | Homotrimer. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002064 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 4758910 | RefSeq | NP_004869 | 152 | prostaglandin E synthase |
Identical Sequences to LMP002064 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4758910 | DBBJ | BAJ20911.1 | 152 | prostaglandin E synthase, partial [synthetic construct] |
| GI:4758910 | GenBank | ADT42240.1 | 152 | Sequence 1186 from patent US 7833706 |
| GI:4758910 | GenBank | AGY15585.1 | 152 | Sequence 6 from patent US 8546077 |
| GI:4758910 | GenBank | AIC50381.1 | 152 | PTGES, partial [synthetic construct] |
| GI:4758910 | PDB | 4AL0 | 152 | Chain A, Crystal Structure Of Human Ps-1 |
| GI:4758910 | PDB | 4AL1 | 152 | Chain A, Crystal Structure Of Human Ps-1 Gsh-analog Complex |
Related Sequences to LMP002064 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4758910 | GenBank | EAW87902.1 | 180 | hCG30600, isoform CRA_a [Homo sapiens] |
| GI:4758910 | GenBank | EAW87904.1 | 180 | hCG30600, isoform CRA_a [Homo sapiens] |
| GI:4758910 | GenBank | ADT42235.1 | 180 | Sequence 1181 from patent US 7833706 |
| GI:4758910 | GenBank | ADT42236.1 | 180 | Sequence 1182 from patent US 7833706 |
| GI:4758910 | GenBank | AFH34732.1 | 152 | prostaglandin E synthase [Macaca mulatta] |
| GI:4758910 | RefSeq | XP_003822411.1 | 152 | PREDICTED: prostaglandin E synthase [Pan paniscus] |