Gene/Proteome Database (LMPD)
LMPD ID
LMP002069
Gene ID
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
Gene Symbol
Synonyms
PI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta
Alternate Names
phosphatidylinositol 5-phosphate 4-kinase type-2 beta; PIP4KII-beta; PTDINS(4)P-5-kinase; PI(5)P 4-kinase type II beta; diphosphoinositide kinase 2-beta; ptdIns(5)P-4-kinase isoform 2-beta; 1-phosphatidylinositol-4-phosphate kinase; 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; 1-phosphatidylinositol-5-phosphate 4-kinase 2-beta; phosphatidylinositol-5-phosphate 4-kinase type-2 beta; phosphatidylinositol 5-phosphate 4-kinase type II beta; phosphatidylinositol-4-phosphate 5-kinase, type II, beta
Chromosome
17
Map Location
17q12
EC Number
2.7.1.149
Summary
The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| phosphatidylinositol 5-phosphate 4-kinase type-2 beta | |
|---|---|
| Refseq ID | NP_003550 |
| Protein GI | 4505819 |
| UniProt ID | P78356 |
| mRNA ID | NM_003559 |
| Length | 416 |
| RefSeq Status | REVIEWED |
| MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT | |
Gene Information
Entrez Gene ID
Gene Name
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0005634 | IEA:UniProtKB-KW | C | nucleus |
| GO:0005886 | IEA:UniProtKB-KW | C | plasma membrane |
| GO:0016308 | IDA:MGI | F | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
| GO:0016309 | IEA:UniProtKB-EC | F | 1-phosphatidylinositol-5-phosphate 4-kinase activity |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0005057 | TAS:ProtInc | F | receptor signaling protein activity |
| GO:0007166 | TAS:ProtInc | P | cell surface receptor signaling pathway |
| GO:0035556 | TAS:GOC | P | intracellular signal transduction |
| GO:0006661 | TAS:Reactome | P | phosphatidylinositol biosynthetic process |
| GO:0046854 | IDA:GOC | P | phosphatidylinositol phosphorylation |
| GO:0006644 | TAS:Reactome | P | phospholipid metabolic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-6352 | 3-phosphoinositide biosynthesis |
| PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_121025 | Synthesis of PIPs at the plasma membrane |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR023610 | Phosphatidylinositol-4-phosphate 5-kinase |
| IPR027483 | Phosphatidylinositol-4-phosphate 5-kinase, C-terminal |
| IPR027484 | Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain |
| IPR002498 | Phosphatidylinositol-4-phosphate 5-kinase, core |
| IPR016034 | Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup |
UniProt Annotations
Entry Information
Gene Name
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
Protein Entry
PI42B_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P78356-1; Sequence=Displayed; Name=2; IsoId=P78356-2; Sequence=VSP_010384, VSP_010385; Note=No experimental confirmation available.; |
| Biophysicochemical Properties | Kinetic parameters: KM=30 uM for phosphatidylinositol-5- phosphate ; Vmax=0.2 pmol/min/ug enzyme ; |
| Catalytic Activity | ATP + 1-phosphatidyl-1D-myo-inositol 5- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. |
| Function | Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. |
| Ptm | Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels. |
| Similarity | Contains 1 PIPK domain. {ECO |
| Subcellular Location | Endoplasmic reticulum membrane {ECO |
| Subunit | Homodimer. Binds TNFRSF1A. Interacts with PIP4K2A. Interaction with PIP4K2A suppresses ubiquitination by the SPOP/ CUL3 complex. {ECO |
| Tissue Specificity | Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002069 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 4505819 | RefSeq | NP_003550 | 416 | phosphatidylinositol 5-phosphate 4-kinase type-2 beta |
Identical Sequences to LMP002069 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4505819 | GenBank | JAB34142.1 | 416 | phosphatidylinositol 5-phosphate 4-kinase type-2 beta [Callithrix jacchus] |
| GI:4505819 | GenBank | JAB48674.1 | 416 | phosphatidylinositol 5-phosphate 4-kinase type-2 beta [Callithrix jacchus] |
| GI:4505819 | GenBank | AHD78602.1 | 416 | Sequence 26600 from patent US 8586006 |
| GI:4505819 | RefSeq | XP_005584038.1 | 416 | PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [Macaca fascicularis] |
| GI:4505819 | RefSeq | XP_008011094.1 | 416 | PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X2 [Chlorocebus sabaeus] |
| GI:4505819 | RefSeq | XP_010377638.1 | 416 | PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 beta [Rhinopithecus roxellana] |
Related Sequences to LMP002069 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4505819 | GenBank | AAV38420.1 | 416 | phosphatidylinositol-4-phosphate 5-kinase, type II, beta [Homo sapiens] |
| GI:4505819 | GenBank | AAX41426.1 | 416 | phosphatidylinositol-4-phosphate 5-kinase type II beta [synthetic construct] |
| GI:4505819 | RefSeq | XP_009188737.1 | 449 | PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [Papio anubis] |
| GI:4505819 | RefSeq | XP_009188738.1 | 449 | PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [Papio anubis] |
| GI:4505819 | RefSeq | XP_009188739.1 | 449 | PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [Papio anubis] |
| GI:4505819 | RefSeq | XP_009188740.1 | 432 | PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X2 [Papio anubis] |