Gene/Proteome Database (LMPD)

LMPD ID
LMP002076
Gene ID
9514
Species
Homo sapiens (Human)
Gene Name
galactose-3-O-sulfotransferase 1
Gene Symbol
GAL3ST1
Synonyms
CST
Alternate Names
galactosylceramide sulfotransferase; GalCer sulfotransferase; cerebroside sulfotransferase', "3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase", "3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase", "cerebroside (3'-phosphoadenylylsulfate:galactosylceramide 3') sulfotransferase
Chromosome
22
Map Location
22q12.2
EC Number
2.8.2.11
Summary
Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for GAL3ST1

Proteins

galactosylceramide sulfotransferase
Refseq ID NP_004852
Protein GI 4758088
UniProt ID Q99999
mRNA ID NM_004861
Length 423
RefSeq Status REVIEWED
MLPPQKKPWESMAKGLVLGALFTSFLLLVYSYAVPPLHAGLASTTPEAAASCSPPALEPEAVIRANGSAGECQPRRNIVFLKTHKTASSTLLNILFRFGQKHRLKFAFPNGRNDFDYPTFFARSLVQDYRPGACFNIICNHMRFHYDEVRGLVPTNAIFITVLRDPARLFESSFHYFGPVVPLTWKLSAGDKLTEFLQDPDRYYDPNGFNAHYLRNLLFFDLGYDNSLDPSSPQVQEHILEVERRFHLVLLQEYFDESLVLLKDLLCWELEDVLYFKLNARRDSPVPRLSGELYGRATAWNMLDSHLYRHFNASFWRKVEAFGRERMAREVAALRHANERMRTICIDGGHAVDAAAIQDEAMQPWQPLGTKSILGYNLKKSIGQRHAQLCRRMLTPEIQYLMDLGANLWVTKLWKFIRDFLRW

Gene Information

Entrez Gene ID
9514
Gene Name
galactose-3-O-sulfotransferase 1
Gene Symbol
GAL3ST1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000139 TAS:Reactome C Golgi membrane
GO:0005887 TAS:ProtInc C integral component of plasma membrane
GO:0016020 TAS:ProtInc C membrane
GO:0001733 IEA:UniProtKB-EC F galactosylceramide sulfotransferase activity
GO:0008146 TAS:ProtInc F sulfotransferase activity
GO:0006682 IEA:Ensembl P galactosylceramide biosynthetic process
GO:0006687 TAS:Reactome P glycosphingolipid metabolic process
GO:0042552 IEA:Ensembl P myelination
GO:0006487 TAS:ProtInc P protein N-linked glycosylation
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0007283 IEA:Ensembl P spermatogenesis
GO:0006665 TAS:Reactome P sphingolipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00600 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR009729 Galactose-3-O-sulfotransferase
IPR027417 P-loop containing nucleoside triphosphate hydrolase

UniProt Annotations

Entry Information

Gene Name
galactose-3-O-sulfotransferase 1
Protein Entry
G3ST1_HUMAN
UniProt ID
Q99999
Species
Human

Comments

Comment Type Description
Catalytic Activity 3'-phosphoadenylyl sulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate.
Catalytic Activity 3'-phosphoadenylyl sulfate + monogalactosylalkylacylglycerol = adenosine 3',5'-bisphosphate + monogalactosylalkylacylglycerol sulfate.
Function Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro). {ECO
Pathway Lipid metabolism; sphingolipid metabolism.
Similarity Belongs to the galactose-3-O-sulfotransferase family.
Subcellular Location Golgi apparatus membrane ; Single-pass type II membrane protein .
Tissue Specificity Expressed in kidney proximal tubule, gastric mucosa and adenocarcinoma. Highly expressed in renal cell carcinoma cell lines.
Web Resource Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=GAL3ST1";

Identical and Related Proteins

Unique RefSeq proteins for LMP002076 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4758088 RefSeq NP_004852 423 galactosylceramide sulfotransferase

Identical Sequences to LMP002076 proteins

Reference Database Accession Length Protein Name
GI:4758088 GenBank EAW59900.1 423 galactose-3-O-sulfotransferase 1, isoform CRA_a [Homo sapiens]
GI:4758088 GenBank EAW59901.1 423 galactose-3-O-sulfotransferase 1, isoform CRA_a [Homo sapiens]
GI:4758088 GenBank EAW59902.1 423 galactose-3-O-sulfotransferase 1, isoform CRA_a [Homo sapiens]
GI:4758088 RefSeq XP_005261905.1 423 PREDICTED: galactosylceramide sulfotransferase isoform X7 [Homo sapiens]
GI:4758088 RefSeq XP_005261910.1 423 PREDICTED: galactosylceramide sulfotransferase isoform X12 [Homo sapiens]
GI:4758088 RefSeq XP_005261913.1 423 PREDICTED: galactosylceramide sulfotransferase isoform X15 [Homo sapiens]

Related Sequences to LMP002076 proteins

Reference Database Accession Length Protein Name
GI:4758088 EMBL CAG30236.1 423 Em:AC005006.2 [Homo sapiens]
GI:4758088 EMBL CAK54491.1 423 GAL3ST1 [synthetic construct]
GI:4758088 EMBL CAK54790.1 423 GAL3ST1, partial [synthetic construct]
GI:4758088 GenBank AAH14649.1 423 GAL3ST1 protein [Homo sapiens]
GI:4758088 GenBank ABM83198.1 423 galactose-3-O-sulfotransferase 1 [synthetic construct]
GI:4758088 GenBank AIC55605.1 423 GAL3ST1, partial [synthetic construct]