Gene/Proteome Database (LMPD)

LMPD ID
LMP002079
Gene ID
1384
Species
Homo sapiens (Human)
Gene Name
carnitine O-acetyltransferase
Gene Symbol
CRAT
Synonyms
CAT1
Alternate Names
carnitine O-acetyltransferase; CAT; carnitine acetylase; carnitine acetyltransferase
Chromosome
9
Map Location
9q34.1
EC Number
2.3.1.7
Summary
This gene encodes carnitine acetyltransferase (CRAT), which is a key enzyme in the metabolic pathway in mitochondria, peroxisomes and endoplasmic reticulum. CRAT catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acylCoA/CoA in the subcellular compartments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Orthologs
View orthologs and multiple alignments for CRAT

Proteins

carnitine O-acetyltransferase isoform 1 precursor
Refseq ID NP_000746
Protein GI 21618331
UniProt ID P43155
mRNA ID NM_000755
Length 626
RefSeq Status REVIEWED
MLAFAARTVVKPLGFLKPFSLMKASSRFKAHQDALPRLPVPPLQQSLDHYLKALQPIVSEEEWAHTKQLVDEFQASGGVGERLQKGLERRARKTENWLSEWWLKTAYLQYRQPVVIYSSPGVMLPKQDFVDLQGQLRFAAKLIEGVLDFKVMIDNETLPVEYLGGKPLCMNQYYQILSSCRVPGPKQDTVSNFSKTKKPPTHITVVHNYQFFELDVYHSDGTPLTADQIFVQLEKIWNSSLQTNKEPVGILTSNHRNSWAKAYNTLIKDKVNRDSVRSIQKSIFTVCLDATMPRVSEDVYRSHVAGQMLHGGGSRLNSGNRWFDKTLQFIVAEDGSCGLVYEHAAAEGPPIVTLLDYVIEYTKKPELVRSPMVPLPMPKKLRFNITPEIKSDIEKAKQNLSIMIQDLDITVMVFHHFGKDFPKSEKLSPDAFIQMALQLAYYRIYGQACATYESASLRMFHLGRTDTIRSASMDSLTFVKAMDDSSVTEHQKVELLRKAVQAHRGYTDRAIRGEAFDRHLLGLKLQAIEDLVSMPDIFMDTSYAIAMHFHLSTSQVPAKTDCVMFFGPVVPDGYGVCYNPMEAHINFSLSAYNSCAETNAARLAHYLEKALLDMRALLQSHPRAKL
carnitine O-acetyltransferase isoform 2
Refseq ID NP_001244292
Protein GI 383209673
UniProt ID P43155
mRNA ID NM_001257363
Length 605
RefSeq Status REVIEWED
MKASSRFKAHQDALPRLPVPPLQQSLDHYLKALQPIVSEEEWAHTKQLVDEFQASGGVGERLQKGLERRARKTENWLSEWWLKTAYLQYRQPVVIYSSPGVMLPKQDFVDLQGQLRFAAKLIEGVLDFKVMIDNETLPVEYLGGKPLCMNQYYQILSSCRVPGPKQDTVSNFSKTKKPPTHITVVHNYQFFELDVYHSDGTPLTADQIFVQLEKIWNSSLQTNKEPVGILTSNHRNSWAKAYNTLIKDKVNRDSVRSIQKSIFTVCLDATMPRVSEDVYRSHVAGQMLHGGGSRLNSGNRWFDKTLQFIVAEDGSCGLVYEHAAAEGPPIVTLLDYVIEYTKKPELVRSPMVPLPMPKKLRFNITPEIKSDIEKAKQNLSIMIQDLDITVMVFHHFGKDFPKSEKLSPDAFIQMALQLAYYRIYGQACATYESASLRMFHLGRTDTIRSASMDSLTFVKAMDDSSVTEHQKVELLRKAVQAHRGYTDRAIRGEAFDRHLLGLKLQAIEDLVSMPDIFMDTSYAIAMHFHLSTSQVPAKTDCVMFFGPVVPDGYGVCYNPMEAHINFSLSAYNSCAETNAARLAHYLEKALLDMRALLQSHPRAKL
transit_peptide: 1..11 calculated_mol_wt: 1207 peptide sequence: MLAFAARTVVK mat_peptide: 12..626 product: carnitine O-acetyltransferase isoform 1 calculated_mol_wt: 69688 peptide sequence: PLGFLKPFSLMKASSRFKAHQDALPRLPVPPLQQSLDHYLKALQPIVSEEEWAHTKQLVDEFQASGGVGERLQKGLERRARKTENWLSEWWLKTAYLQYRQPVVIYSSPGVMLPKQDFVDLQGQLRFAAKLIEGVLDFKVMIDNETLPVEYLGGKPLCMNQYYQILSSCRVPGPKQDTVSNFSKTKKPPTHITVVHNYQFFELDVYHSDGTPLTADQIFVQLEKIWNSSLQTNKEPVGILTSNHRNSWAKAYNTLIKDKVNRDSVRSIQKSIFTVCLDATMPRVSEDVYRSHVAGQMLHGGGSRLNSGNRWFDKTLQFIVAEDGSCGLVYEHAAAEGPPIVTLLDYVIEYTKKPELVRSPMVPLPMPKKLRFNITPEIKSDIEKAKQNLSIMIQDLDITVMVFHHFGKDFPKSEKLSPDAFIQMALQLAYYRIYGQACATYESASLRMFHLGRTDTIRSASMDSLTFVKAMDDSSVTEHQKVELLRKAVQAHRGYTDRAIRGEAFDRHLLGLKLQAIEDLVSMPDIFMDTSYAIAMHFHLSTSQVPAKTDCVMFFGPVVPDGYGVCYNPMEAHINFSLSAYNSCAETNAARLAHYLEKALLDMRALLQSHPRAKL

Gene Information

Entrez Gene ID
1384
Gene Name
carnitine O-acetyltransferase
Gene Symbol
CRAT
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0005743 IEA:UniProtKB-KW C mitochondrial inner membrane
GO:0005739 IDA:UniProtKB C mitochondrion
GO:0005782 TAS:Reactome C peroxisomal matrix
GO:0005777 IDA:UniProtKB C peroxisome
GO:0004092 IDA:UniProtKB F carnitine O-acetyltransferase activity
GO:0005102 IPI:UniProtKB F receptor binding
GO:0019254 IDA:UniProtKB P carnitine metabolic process, CoA-linked
GO:0044255 TAS:Reactome P cellular lipid metabolic process
GO:0033540 TAS:Reactome P fatty acid beta-oxidation using acyl-CoA oxidase
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006810 IEA:UniProtKB-KW P transport

KEGG Pathway Links

KEGG Pathway ID Description
hsa04146 Peroxisome

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_17017 Beta-oxidation of pristanoyl-CoA
REACT_17062 Beta-oxidation of very long chain fatty acids

Domain Information

InterPro Annotations

Accession Description
IPR000542 Acyltransferase ChoActase/COT/CPT

UniProt Annotations

Entry Information

Gene Name
carnitine O-acetyltransferase
Protein Entry
CACP_HUMAN
UniProt ID
P43155
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=SM-1400; IsoId=P43155-1; Sequence=Displayed; Name=2; Synonyms=SM-1200; IsoId=P43155-2; Sequence=VSP_000792; Note=No experimental confirmation available.; Name=3; IsoId=P43155-3; Sequence=VSP_012798;
Catalytic Activity Acetyl-CoA + carnitine = CoA + O- acetylcarnitine.
Function Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.
Similarity Belongs to the carnitine/choline acetyltransferase family.
Subcellular Location Endoplasmic reticulum . Peroxisome . Mitochondrion inner membrane {ECO
Subcellular Location Isoform 1: Mitochondrion .
Subcellular Location Isoform 2: Peroxisome .
Subunit Monomer. {ECO
Tissue Specificity Mostly in skeletal muscle, less in heart, liver and pancreas, only weakly detectable in brain, placenta, lung and kidney.

Identical and Related Proteins

Unique RefSeq proteins for LMP002079 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21618331 RefSeq NP_000746 626 carnitine O-acetyltransferase isoform 1 precursor
383209673 RefSeq NP_001244292 605 carnitine O-acetyltransferase isoform 2

Identical Sequences to LMP002079 proteins

Reference Database Accession Length Protein Name
GI:21618331 GenBank EAW87874.1 626 carnitine acetyltransferase, isoform CRA_b [Homo sapiens]
GI:383209673 GenBank EAW87875.1 605 carnitine acetyltransferase, isoform CRA_c [Homo sapiens]
GI:21618331 GenBank ADT49251.1 626 Sequence 1268 from patent US 7842467
GI:383209673 GenBank ADT49252.1 605 Sequence 1269 from patent US 7842467
GI:21618331 GenBank ADT49254.1 626 Sequence 1271 from patent US 7842467
GI:383209673 GenBank ADT49256.1 605 Sequence 1273 from patent US 7842467

Related Sequences to LMP002079 proteins

Reference Database Accession Length Protein Name
GI:21618331 EMBL CAD34960.1 626 unnamed protein product [Homo sapiens]
GI:383209673 GenBank EAW87874.1 626 carnitine acetyltransferase, isoform CRA_b [Homo sapiens]
GI:383209673 GenBank ACM84291.1 627 Sequence 9789 from patent US 6812339
GI:383209673 GenBank ACM84292.1 627 Sequence 9790 from patent US 6812339
GI:21618331 GenBank ACM84293.1 634 Sequence 9791 from patent US 6812339
GI:21618331 GenBank ACM84294.1 634 Sequence 9792 from patent US 6812339
GI:383209673 GenBank ADT49251.1 626 Sequence 1268 from patent US 7842467
GI:383209673 GenBank ADT49254.1 626 Sequence 1271 from patent US 7842467
GI:21618331 GenBank JAA08252.1 626 carnitine O-acetyltransferase [Pan troglodytes]
GI:21618331 GenBank JAA12305.1 626 carnitine O-acetyltransferase [Pan troglodytes]
GI:383209673 RefSeq NP_000746.2 626 carnitine O-acetyltransferase isoform 1 precursor [Homo sapiens]
GI:21618331 SwissProt P43155.5 626 RecName: Full=Carnitine O-acetyltransferase; Short=Carnitine acetylase; AltName: Full=Carnitine acetyltransferase; Short=CAT; Short=CrAT [Homo sapiens]