Gene/Proteome Database (LMPD)
LMPD ID
LMP002087
Gene ID
Species
Homo sapiens (Human)
Gene Name
phospholipase C, delta 1
Gene Symbol
Synonyms
NDNC3; PLC-III
Chromosome
3
Map Location
3p22-p21.3
EC Number
3.1.4.11
Summary
This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Orthologs
Proteins
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 1 | |
---|---|
Refseq ID | NP_001124436 |
Protein GI | 195972883 |
UniProt ID | P51178 |
mRNA ID | NM_001130964 |
Length | 777 |
RefSeq Status | REVIEWED |
MQCLGIRSRSRSRELYLQERSLKVAALNGRRLGLQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRTPESQLFSIEDIQEVRMGHRTEGLEKFARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 2 | |
---|---|
Refseq ID | NP_006216 |
Protein GI | 90265805 |
UniProt ID | P51178 |
mRNA ID | NM_006225 |
Length | 756 |
RefSeq Status | REVIEWED |
MDSGRDFLTLHGLQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRTPESQLFSIEDIQEVRMGHRTEGLEKFARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD |
Gene Information
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005737 | IDA:MGI | C | cytoplasm |
GO:0005829 | IEA:Ensembl | C | cytosol |
GO:0070062 | IDA:UniProt | C | extracellular vesicular exosome |
GO:0005886 | TAS:Reactome | C | plasma membrane |
GO:0032794 | IPI:BHF-UCL | F | GTPase activating protein binding |
GO:0005509 | IEA:InterPro | F | calcium ion binding |
GO:0070300 | IEA:Ensembl | F | phosphatidic acid binding |
GO:1901981 | IEA:Ensembl | F | phosphatidylinositol phosphate binding |
GO:0004435 | TAS:ProtInc | F | phosphatidylinositol phospholipase C activity |
GO:0001786 | IEA:Ensembl | F | phosphatidylserine binding |
GO:0004871 | IEA:UniProtKB-KW | F | signal transducer activity |
GO:0001525 | IEA:Ensembl | P | angiogenesis |
GO:0043647 | TAS:Reactome | P | inositol phosphate metabolic process |
GO:0035556 | IEA:InterPro | P | intracellular signal transduction |
GO:0060716 | IEA:Ensembl | P | labyrinthine layer blood vessel development |
GO:0016042 | IEA:UniProtKB-KW | P | lipid catabolic process |
GO:0006644 | TAS:ProtInc | P | phospholipid metabolic process |
GO:0042127 | IEA:Ensembl | P | regulation of cell proliferation |
GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
KEGG Pathway Links
KEGG Pathway ID | Description |
---|---|
hsa04020 | Calcium signaling pathway |
hsa04919 | Thyroid hormone signaling pathway |
REACTOME Pathway Links
REACTOME Pathway ID | Description |
---|---|
REACT_150312 | Synthesis of IP3 and IP4 in the cytosol |
Domain Information
InterPro Annotations
Accession | Description |
---|---|
IPR028391 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 |
IPR000008 | C2 domain |
IPR018247 | EF-Hand 1, calcium-binding site |
IPR002048 | EF-hand domain |
IPR011992 | EF-hand domain pair |
IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain |
IPR001192 | Phosphoinositide phospholipase C family |
IPR000909 | Phospholipase C, phosphatidylinositol-specific , X domain |
IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
IPR015359 | Phospholipase C, phosphoinositol-specific, EF-hand-like |
IPR001849 | Pleckstrin homology domain |
IPR011993 | Pleckstrin homology-like domain |
UniProt Annotations
Entry Information
Comments
Comment Type | Description |
---|---|
Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P51178-1; Sequence=Displayed; Name=2; IsoId=P51178-2; Sequence=VSP_042919; Note=No experimental confirmation available.; |
Catalytic Activity | 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. |
Cofactor | Name=Ca(2+); Xref=ChEBI |
Disease | Nail disorder, non-syndromic congenital, 3 (NDNC3) [MIM |
Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. |
Similarity | Contains 1 C2 domain. {ECO |
Similarity | Contains 1 PH domain. {ECO |
Similarity | Contains 1 PI-PLC X-box domain. {ECO |
Similarity | Contains 1 PI-PLC Y-box domain. {ECO |
Similarity | Contains 2 EF-hand domains. {ECO |
Web Resource | Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PLCD1ID43927ch3p22.html"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP002087 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
195972883 | RefSeq | NP_001124436 | 777 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 1 |
90265805 | RefSeq | NP_006216 | 756 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 2 |
Identical Sequences to LMP002087 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:195972883 | DBBJ | BAG52226.1 | 777 | unnamed protein product [Homo sapiens] |
GI:90265805 | GenBank | AAH50382.2 | 756 | Phospholipase C, delta 1 [Homo sapiens] |
GI:195972883 | GenBank | ABA66463.1 | 777 | Sequence 2105 from patent US 6943241 |
GI:90265805 | GenBank | EAW64507.1 | 756 | phospholipase C, delta 1 [Homo sapiens] |
GI:90265805 | GenBank | AED62131.1 | 756 | Sequence 11 from patent US 7902154 |
GI:90265805 | SwissProt | P51178.2 | 756 | RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; AltName: Full=Phosphoinositide phospholipase C-delta-1; AltName: Full=Phospholipase C-III; Short=PLC-III; AltName: Full=Phospholipase C-delta-1; Short=PLC-delta-1 [Homo sapiens] |
Related Sequences to LMP002087 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:90265805 | DBBJ | BAD93099.1 | 776 | Phospholipase C, delta 1 variant, partial [Homo sapiens] |
GI:90265805 | DBBJ | BAF85013.1 | 756 | unnamed protein product [Homo sapiens] |
GI:90265805 | DBBJ | BAG10970.1 | 756 | phospholipase C, delta 1, partial [synthetic construct] |
GI:195972883 | EMBL | CAI46087.1 | 777 | hypothetical protein [Homo sapiens] |
GI:195972883 | GenBank | JAA05681.1 | 779 | phospholipase C, delta 1 [Pan troglodytes] |
GI:90265805 | GenBank | JAA22773.1 | 756 | phospholipase C, delta 1 [Pan troglodytes] |
GI:195972883 | GenBank | JAA22774.1 | 779 | phospholipase C, delta 1 [Pan troglodytes] |
GI:90265805 | GenBank | JAA36671.1 | 756 | phospholipase C, delta 1 [Pan troglodytes] |
GI:195972883 | GenBank | JAA36672.1 | 779 | phospholipase C, delta 1 [Pan troglodytes] |
GI:195972883 | RefSeq | XP_003826154.1 | 781 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [Pan paniscus] |
GI:90265805 | RefSeq | XP_004033888.1 | 756 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 1 [Gorilla gorilla gorilla] |
GI:195972883 | RefSeq | XP_004033889.1 | 777 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 2 [Gorilla gorilla gorilla] |