Gene/Proteome Database (LMPD)

LMPD ID
LMP002087
Gene ID
5333
Species
Homo sapiens (Human)
Gene Name
phospholipase C, delta 1
Gene Symbol
PLCD1
Synonyms
NDNC3; PLC-III
Chromosome
3
Map Location
3p22-p21.3
EC Number
3.1.4.11
Summary
This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Orthologs
View orthologs and multiple alignments for PLCD1

Proteins

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 1
Refseq ID NP_001124436
Protein GI 195972883
UniProt ID P51178
mRNA ID NM_001130964
Length 777
RefSeq Status REVIEWED
MQCLGIRSRSRSRELYLQERSLKVAALNGRRLGLQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRTPESQLFSIEDIQEVRMGHRTEGLEKFARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 2
Refseq ID NP_006216
Protein GI 90265805
UniProt ID P51178
mRNA ID NM_006225
Length 756
RefSeq Status REVIEWED
MDSGRDFLTLHGLQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRTPESQLFSIEDIQEVRMGHRTEGLEKFARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD

Gene Information

Entrez Gene ID
5333
Gene Name
phospholipase C, delta 1
Gene Symbol
PLCD1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:MGI C cytoplasm
GO:0005829 IEA:Ensembl C cytosol
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0005886 TAS:Reactome C plasma membrane
GO:0005509 IEA:InterPro F calcium ion binding
GO:0032794 IPI:BHF-UCL F GTPase activating protein binding
GO:0070300 IEA:Ensembl F phosphatidic acid binding
GO:1901981 IEA:Ensembl F phosphatidylinositol phosphate binding
GO:0004435 TAS:ProtInc F phosphatidylinositol phospholipase C activity
GO:0001786 IEA:Ensembl F phosphatidylserine binding
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0001525 IEA:Ensembl P angiogenesis
GO:0043647 TAS:Reactome P inositol phosphate metabolic process
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0060716 IEA:Ensembl P labyrinthine layer blood vessel development
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0006644 TAS:ProtInc P phospholipid metabolic process
GO:0042127 IEA:Ensembl P regulation of cell proliferation
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04020 Calcium signaling pathway
hsa04919 Thyroid hormone signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_150312 Synthesis of IP3 and IP4 in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR028391 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
IPR000008 C2 domain
IPR018247 EF-Hand 1, calcium-binding site
IPR002048 EF-hand domain
IPR011992 EF-hand domain pair
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
phospholipase C, delta 1
Protein Entry
PLCD1_HUMAN
UniProt ID
P51178
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P51178-1; Sequence=Displayed; Name=2; IsoId=P51178-2; Sequence=VSP_042919; Note=No experimental confirmation available.;
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Cofactor Name=Ca(2+); Xref=ChEBI
Disease Nail disorder, non-syndromic congenital, 3 (NDNC3) [MIM
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development.
Similarity Contains 1 C2 domain. {ECO
Similarity Contains 1 PH domain. {ECO
Similarity Contains 1 PI-PLC X-box domain. {ECO
Similarity Contains 1 PI-PLC Y-box domain. {ECO
Similarity Contains 2 EF-hand domains. {ECO
Web Resource Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PLCD1ID43927ch3p22.html";

Identical and Related Proteins

Unique RefSeq proteins for LMP002087 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
195972883 RefSeq NP_001124436 777 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 1
90265805 RefSeq NP_006216 756 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 2

Identical Sequences to LMP002087 proteins

Reference Database Accession Length Protein Name
GI:195972883 DBBJ BAG52226.1 777 unnamed protein product [Homo sapiens]
GI:90265805 GenBank AAH50382.2 756 Phospholipase C, delta 1 [Homo sapiens]
GI:195972883 GenBank ABA66463.1 777 Sequence 2105 from patent US 6943241
GI:90265805 GenBank EAW64507.1 756 phospholipase C, delta 1 [Homo sapiens]
GI:90265805 GenBank AED62131.1 756 Sequence 11 from patent US 7902154
GI:90265805 SwissProt P51178.2 756 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; AltName: Full=Phosphoinositide phospholipase C-delta-1; AltName: Full=Phospholipase C-III; Short=PLC-III; AltName: Full=Phospholipase C-delta-1; Short=PLC-delta-1 [Homo sapiens]

Related Sequences to LMP002087 proteins

Reference Database Accession Length Protein Name
GI:90265805 DBBJ BAD93099.1 776 Phospholipase C, delta 1 variant, partial [Homo sapiens]
GI:90265805 DBBJ BAF85013.1 756 unnamed protein product [Homo sapiens]
GI:90265805 DBBJ BAG10970.1 756 phospholipase C, delta 1, partial [synthetic construct]
GI:195972883 EMBL CAI46087.1 777 hypothetical protein [Homo sapiens]
GI:195972883 GenBank JAA05681.1 779 phospholipase C, delta 1 [Pan troglodytes]
GI:90265805 GenBank JAA22773.1 756 phospholipase C, delta 1 [Pan troglodytes]
GI:195972883 GenBank JAA22774.1 779 phospholipase C, delta 1 [Pan troglodytes]
GI:90265805 GenBank JAA36671.1 756 phospholipase C, delta 1 [Pan troglodytes]
GI:195972883 GenBank JAA36672.1 779 phospholipase C, delta 1 [Pan troglodytes]
GI:195972883 RefSeq XP_003826154.1 781 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [Pan paniscus]
GI:90265805 RefSeq XP_004033888.1 756 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 1 [Gorilla gorilla gorilla]
GI:195972883 RefSeq XP_004033889.1 777 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 2 [Gorilla gorilla gorilla]