Gene/Proteome Database (LMPD)

LMPD ID
LMP002088
Gene ID
2100
Species
Homo sapiens (Human)
Gene Name
estrogen receptor 2 (ER beta)
Gene Symbol
ESR2
Synonyms
ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2
Chromosome
14
Map Location
14q23.2
Summary
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for ESR2

Proteins

estrogen receptor beta isoform 1
Refseq ID NP_001428
Protein GI 10835013
UniProt ID Q92731
mRNA ID NM_001437
Length 530
RefSeq Status REVIEWED
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
estrogen receptor beta isoform 2
Refseq ID NP_001278641
Protein GI 619328973
UniProt ID Q92731
mRNA ID NM_001291712
Length 495
RefSeq Status REVIEWED
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHARAEKASQTLTSFGMKMETLLPEATMEQ
estrogen receptor beta isoform 2
Refseq ID NP_001278652
Protein GI 619328993
UniProt ID Q92731
mRNA ID NM_001291723
Length 495
RefSeq Status REVIEWED
Protein sequence is identical to GI:619328973 (mRNA isoform)
estrogen receptor beta isoform 2
Refseq ID NP_001035365
Protein GI 94538325
UniProt ID Q92731
mRNA ID NM_001040275
Length 495
RefSeq Status REVIEWED
Protein sequence is identical to GI:619328973 (mRNA isoform)
estrogen receptor beta isoform 3
Refseq ID NP_001201831
Protein GI 333609293
UniProt ID Q92731
mRNA ID NM_001214902
Length 481
RefSeq Status REVIEWED
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHARWGEKQFIHLKLS
estrogen receptor beta isoform 5
Refseq ID NP_001258805
Protein GI 333609293
UniProt ID Q92731
mRNA ID NM_001271876
Length 481
RefSeq Status REVIEWED
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHARWGEKQFIHLKLS
estrogen receptor beta isoform 6
Refseq ID NP_001258806
Protein GI 428673533
UniProt ID Q92731
mRNA ID NM_001271877
Length 439
RefSeq Status REVIEWED
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ

Gene Information

Entrez Gene ID
2100
Gene Name
estrogen receptor 2 (ER beta)
Gene Symbol
ESR2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-SubCell C nucleus
GO:0043565 IEA:InterPro F sequence-specific DNA binding
GO:0003700 IEA:InterPro F sequence-specific DNA binding transcription factor activity
GO:0005496 IEA:InterPro F steroid binding
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
hsa04915 Estrogen signaling pathway
hsa04917 Prolactin signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR021064 Estrogen receptor beta, N-terminal
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR024178 Oestrogen receptor/oestrogen-related receptor
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
estrogen receptor 2 (ER beta)
Protein Entry
ESR2_HUMAN
UniProt ID
Q92731
Species
Human

Comments

Comment Type Description
Similarity Belongs to the nuclear hormone receptor family.
Similarity Belongs to the nuclear hormone receptor family. NR3 subfamily.
Similarity Contains nuclear receptor DNA-binding domain.
Subcellular Location Nucleus .

Identical and Related Proteins

Unique RefSeq proteins for LMP002088 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
10835013 RefSeq NP_001428 530 estrogen receptor beta isoform 1
619328973 RefSeq NP_001278641 495 estrogen receptor beta isoform 2
333609293 RefSeq NP_001201831 481 estrogen receptor beta isoform 3
333609293 RefSeq NP_001258805 481 estrogen receptor beta isoform 5
428673533 RefSeq NP_001258806 439 estrogen receptor beta isoform 6

Identical Sequences to LMP002088 proteins

Reference Database Accession Length Protein Name
GI:619328973 DBBJ BAF85059.1 495 unnamed protein product [Homo sapiens]
GI:10835013 EMBL CEF39419.1 530 unnamed protein product [Homo sapiens]
GI:333609293 GenBank ABH09189.1 481 estrogen receptor beta isoform 4 [Homo sapiens]
GI:333609293 GenBank ABH09189.1 481 estrogen receptor beta isoform 4 [Homo sapiens]
GI:10835013 GenBank EAW80846.1 530 estrogen receptor 2 (ER beta), isoform CRA_a [Homo sapiens]
GI:10835013 GenBank EAW80847.1 530 estrogen receptor 2 (ER beta), isoform CRA_a [Homo sapiens]
GI:619328973 GenBank EAW80851.1 495 estrogen receptor 2 (ER beta), isoform CRA_d [Homo sapiens]
GI:619328973 GenBank EAW80852.1 495 estrogen receptor 2 (ER beta), isoform CRA_d [Homo sapiens]
GI:428673533 GenBank EAW80853.1 439 estrogen receptor 2 (ER beta), isoform CRA_e, partial [Homo sapiens]
GI:10835013 GenBank ABN27702.1 530 Sequence 2 from patent US 7157568
GI:10835013 GenBank ADZ17331.1 530 estrogen nuclear receptor beta variant a [Homo sapiens]
GI:619328973 GenBank ADZ17332.1 495 estrogen nuclear receptor beta variant b [Homo sapiens]
GI:10835013 GenBank AHW56473.1 530 estrogen receptor 2 isoform A, partial [Homo sapiens]
GI:619328973 RefSeq XP_006720139.1 495 PREDICTED: estrogen receptor beta isoform X2 [Homo sapiens]
GI:619328973 RefSeq NP_001278652.1 495 estrogen receptor beta isoform 2 [Homo sapiens]

Related Sequences to LMP002088 proteins

Reference Database Accession Length Protein Name
GI:10835013 GenBank AAN92751.1 548 Sequence 1 from patent US 6458551
GI:10835013 GenBank AAQ25142.1 548 Sequence 1 from patent US 6562592
GI:333609293 GenBank ABH09190.1 472 estrogen receptor beta isoform 5 [Homo sapiens]
GI:333609293 GenBank ABH09190.1 472 estrogen receptor beta isoform 5 [Homo sapiens]
GI:333609293 GenBank ABY09433.1 555 Sequence 1 from patent US 7301014
GI:333609293 GenBank ABY09433.1 555 Sequence 1 from patent US 7301014
GI:10835013 GenBank ACM81936.1 551 Sequence 7434 from patent US 6812339
GI:619328973 RefSeq XP_001170225.1 495 PREDICTED: estrogen receptor beta isoform X2 [Pan troglodytes]
GI:10835013 RefSeq XP_001170310.1 530 PREDICTED: estrogen receptor beta isoform X1 [Pan troglodytes]
GI:619328973 RefSeq XP_004055332.1 495 PREDICTED: estrogen receptor beta isoform 2 [Gorilla gorilla gorilla]
GI:333609293 RefSeq XP_004055333.1 481 PREDICTED: estrogen receptor beta isoform 3 [Gorilla gorilla gorilla]
GI:333609293 RefSeq XP_004055333.1 481 PREDICTED: estrogen receptor beta isoform 3 [Gorilla gorilla gorilla]
GI:333609293 RefSeq XP_003267844.2 481 PREDICTED: estrogen receptor beta isoform 3 [Nomascus leucogenys]
GI:333609293 RefSeq XP_003267844.2 481 PREDICTED: estrogen receptor beta isoform 3 [Nomascus leucogenys]
GI:428673533 RefSeq XP_004409416.1 458 PREDICTED: estrogen receptor beta isoform 2 [Odobenus rosmarus divergens]
GI:428673533 RefSeq XP_008137181.1 456 PREDICTED: estrogen receptor beta isoform X2 [Eptesicus fuscus]
GI:428673533 RefSeq XP_008699240.1 458 PREDICTED: estrogen receptor beta isoform X2 [Ursus maritimus]
GI:619328973 RefSeq XP_008955209.1 490 PREDICTED: estrogen receptor beta isoform X2 [Pan paniscus]
GI:619328973 RefSeq XP_008955210.1 490 PREDICTED: estrogen receptor beta isoform X2 [Pan paniscus]
GI:619328973 RefSeq XP_008955211.1 490 PREDICTED: estrogen receptor beta isoform X2 [Pan paniscus]
GI:333609293 RefSeq XP_008955212.1 481 PREDICTED: estrogen receptor beta isoform X3 [Pan paniscus]
GI:333609293 RefSeq XP_008955212.1 481 PREDICTED: estrogen receptor beta isoform X3 [Pan paniscus]
GI:428673533 RefSeq XP_008955214.1 439 PREDICTED: estrogen receptor beta isoform X5 [Pan paniscus]
GI:428673533 RefSeq XP_009247429.1 440 PREDICTED: estrogen receptor beta isoform X5 [Pongo abelii]
GI:10835013 RefSeq XP_009426202.1 530 PREDICTED: estrogen receptor beta isoform X1 [Pan troglodytes]
GI:10835013 RefSeq XP_009426203.1 530 PREDICTED: estrogen receptor beta isoform X1 [Pan troglodytes]
GI:619328973 RefSeq XP_009426204.1 495 PREDICTED: estrogen receptor beta isoform X2 [Pan troglodytes]
GI:333609293 RefSeq XP_010381992.1 481 PREDICTED: estrogen receptor beta isoform X3 [Rhinopithecus roxellana]
GI:333609293 RefSeq XP_010381992.1 481 PREDICTED: estrogen receptor beta isoform X3 [Rhinopithecus roxellana]
GI:428673533 RefSeq XP_010381994.1 439 PREDICTED: estrogen receptor beta isoform X5 [Rhinopithecus roxellana]