Gene/Proteome Database (LMPD)
LMPD ID
LMP002094
Gene ID
Species
Homo sapiens (Human)
Gene Name
sialidase 3 (membrane sialidase)
Gene Symbol
Synonyms
SIAL3
Alternate Names
sialidase-3; neuraminidase 3; membrane sialidase; ganglioside sialidase; N-acetyl-alpha-neuraminidase 3
Chromosome
11
Map Location
11q13.5
EC Number
3.2.1.18
Summary
This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| sialidase-3 | |
|---|---|
| Refseq ID | NP_006647 |
| Protein GI | 117190519 |
| UniProt ID | Q9UQ49 |
| mRNA ID | NM_006656 |
| Length | 461 |
| RefSeq Status | REVIEWED |
| MRPADLPPRPMEESPASSSAPTETEEPGSSAEVMEEVTTCSFNSPLFRQEDDRGITYRIPALLYIPPTHTFLAFAEKRSTRRDEDALHLVLRRGLRIGQLVQWGPLKPLMEATLPGHRTMNPCPVWEQKSGCVFLFFICVRGHVTERQQIVSGRNAARLCFIYSQDAGCSWSEVRDLTEEVIGSELKHWATFAVGPGHGIQLQSGRLVIPAYTYYIPSWFFCFQLPCKTRPHSLMIYSDDLGVTWHHGRLIRPMVTVECEVAEVTGRAGHPVLYCSARTPNRCRAEALSTDHGEGFQRLALSRQLCEPPHGCQGSVVSFRPLEIPHRCQDSSSKDAPTIQQSSPGSSLRLEEEAGTPSESWLLYSHPTSRKQRVDLGIYLNQTPLEAACWSRPWILHCGPCGYSDLAALEEEGLFGCLFECGTKQECEQIAFRLFTHREILSHLQGDCTSPGRNPSQFKSN | |
Gene Information
Entrez Gene ID
Gene Name
sialidase 3 (membrane sialidase)
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005887 | TAS:ProtInc | C | integral component of plasma membrane |
| GO:0005886 | IDA:MGI | C | plasma membrane |
| GO:0016997 | IDA:MGI | F | alpha-sialidase activity |
| GO:0052794 | ISS:UniProtKB | F | exo-alpha-(2->3)-sialidase activity |
| GO:0052795 | IEA:UniProtKB-EC | F | exo-alpha-(2->6)-sialidase activity |
| GO:0052796 | ISS:UniProtKB | F | exo-alpha-(2->8)-sialidase activity |
| GO:0004308 | IDA:UniProtKB | F | exo-alpha-sialidase activity |
| GO:0005975 | IDA:MGI | P | carbohydrate metabolic process |
| GO:0006689 | IDA:UniProtKB | P | ganglioside catabolic process |
| GO:0006687 | TAS:Reactome | P | glycosphingolipid metabolic process |
| GO:0009313 | IDA:UniProtKB | P | oligosaccharide catabolic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0006665 | TAS:Reactome | P | sphingolipid metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa00600 | Sphingolipid metabolism |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_116105 | Glycosphingolipid metabolism |
| REACT_200874 | Sialic acid metabolism |
| REACT_22387 | Synthesis of substrates in N-glycan biosythesis |
Domain Information
UniProt Annotations
Entry Information
Gene Name
sialidase 3 (membrane sialidase)
Protein Entry
NEUR3_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UQ49-1; Sequence=Displayed; Name=2; IsoId=Q9UQ49-2; Sequence=VSP_054145; |
| Biophysicochemical Properties | pH dependence: Optimum pH is 3.8.; |
| Catalytic Activity | Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. {ECO |
| Function | Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates. {ECO |
| Sequence Caution | Sequence=CAB96131.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; |
| Similarity | Belongs to the glycosyl hydrolase 33 family. |
| Similarity | Contains 3 BNR repeats. |
| Subcellular Location | Cell membrane ; Peripheral membrane protein . |
| Tissue Specificity | Highly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas, liver, heart and thymus. Weakly expressed in kidney, placenta, brain and lung. |
| Web Resource | Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/NEU3ID44505ch11q13.html"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP002094 (as displayed in Record Overview)
Identical Sequences to LMP002094 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:117190519 | DBBJ | BAF83131.1 | 461 | unnamed protein product [Homo sapiens] |
| GI:117190519 | DBBJ | BAG51074.1 | 461 | unnamed protein product [Homo sapiens] |
| GI:117190519 | GenBank | EAW74953.1 | 461 | sialidase 3 (membrane sialidase), isoform CRA_a [Homo sapiens] |
| GI:117190519 | GenBank | EAW74954.1 | 461 | sialidase 3 (membrane sialidase), isoform CRA_a [Homo sapiens] |
| GI:117190519 | GenBank | AAI44060.1 | 461 | NEU3 protein [Homo sapiens] |
| GI:117190519 | GenBank | AAI36398.1 | 461 | NEU3 protein [Homo sapiens] |
Related Sequences to LMP002094 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:117190519 | EMBL | CAB96131.1 | 629 | Nuraminidase [Homo sapiens] |
| GI:117190519 | GenBank | ACM83942.1 | 484 | Sequence 9440 from patent US 6812339 |
| GI:117190519 | GenBank | JAA10072.1 | 461 | sialidase 3 (membrane sialidase) [Pan troglodytes] |
| GI:117190519 | RefSeq | XP_003814742.1 | 629 | PREDICTED: LOW QUALITY PROTEIN: sialidase-3 [Pan paniscus] |
| GI:117190519 | RefSeq | XP_003952031.1 | 629 | PREDICTED: LOW QUALITY PROTEIN: sialidase-3 [Pan troglodytes] |
| GI:117190519 | RefSeq | XP_004051867.1 | 628 | PREDICTED: LOW QUALITY PROTEIN: sialidase-3 [Gorilla gorilla gorilla] |