Gene/Proteome Database (LMPD)

LMPD ID
LMP002099
Gene ID
110695
Species
Mus musculus (Mouse)
Gene Name
aldehyde dehydrogenase family 7, member A1
Gene Symbol
Aldh7a1
Synonyms
Atq1; D18Wsu181e
Alternate Names
alpha-aminoadipic semialdehyde dehydrogenase; antiquitin-1; P6c dehydrogenase; alpha-AASA dehydrogenase; betaine aldehyde dehydrogenase; aldehyde dehydrogenase 7 family, member A1; delta1-piperideine-6-carboxylate dehydrogenase; delta1-piperideine-6-carboxylate dehydrogenease
Chromosome
18
Map Location
18 D3|18 30.55 cM
EC Number
1.2.1.31

Proteins

alpha-aminoadipic semialdehyde dehydrogenase isoform a
Refseq ID NP_613066
Protein GI 188219757
UniProt ID Q9DBF1
mRNA ID NM_138600
Length 539
RefSeq Status VALIDATED
MWRVPRRLCVQSVKTSKLSGPWSRPAAHMSTLLIHHPQYAWLQDLGLREDNEGVYNGSWGGRGEVITTYCPANNEPIARVRQASLKDYEETIGKAKKAWNIWADIPAPKRGEIVRKIGDAFREKIQLLGRLVSLEMGKILVEGIGEVQEYVDVCDYAAGLSRMIGGPTLPSERPGHALIEMWNPLGLVGIITAFNFPVAVFGWNNAIALITGNVCLWKGAPTTSLVSVAVTKIIAQVLEDNLLPGAICSLVCGGADIGTTMARDERVNLLSFTGSTQVGKEVALMVQERFGKSLLELGGNNAIIAFEDADLSLVVPSVLFAAVGTAGQRCTTVRRLFLHESIHNEVVDRLRSAYSQIRVGNPWDPNILYGPLHTKQAVSMFVRAVEEAKKQGGTVVYGGKVMDHPGNYVEPTIVTGLAHDAPIVHQETFAPILYVFKFQDEEEVFEWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSTSLPLAQGIKFQ
transit_peptide: 1..26 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q9DBF1.4) calculated_mol_wt: 3027 peptide sequence: MWRVPRRLCVQSVKTSKLSGPWSRPA mat_peptide: 27..539 product: Alpha-aminoadipic semialdehyde dehydrogenase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9DBF1.4) calculated_mol_wt: 55853 peptide sequence: AHMSTLLIHHPQYAWLQDLGLREDNEGVYNGSWGGRGEVITTYCPANNEPIARVRQASLKDYEETIGKAKKAWNIWADIPAPKRGEIVRKIGDAFREKIQLLGRLVSLEMGKILVEGIGEVQEYVDVCDYAAGLSRMIGGPTLPSERPGHALIEMWNPLGLVGIITAFNFPVAVFGWNNAIALITGNVCLWKGAPTTSLVSVAVTKIIAQVLEDNLLPGAICSLVCGGADIGTTMARDERVNLLSFTGSTQVGKEVALMVQERFGKSLLELGGNNAIIAFEDADLSLVVPSVLFAAVGTAGQRCTTVRRLFLHESIHNEVVDRLRSAYSQIRVGNPWDPNILYGPLHTKQAVSMFVRAVEEAKKQGGTVVYGGKVMDHPGNYVEPTIVTGLAHDAPIVHQETFAPILYVFKFQDEEEVFEWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSTSLPLAQGIKFQ
alpha-aminoadipic semialdehyde dehydrogenase isoform b
Refseq ID NP_001120810
Protein GI 188035915
UniProt ID Q9DBF1
mRNA ID NM_001127338
Length 511
RefSeq Status VALIDATED
MSTLLIHHPQYAWLQDLGLREDNEGVYNGSWGGRGEVITTYCPANNEPIARVRQASLKDYEETIGKAKKAWNIWADIPAPKRGEIVRKIGDAFREKIQLLGRLVSLEMGKILVEGIGEVQEYVDVCDYAAGLSRMIGGPTLPSERPGHALIEMWNPLGLVGIITAFNFPVAVFGWNNAIALITGNVCLWKGAPTTSLVSVAVTKIIAQVLEDNLLPGAICSLVCGGADIGTTMARDERVNLLSFTGSTQVGKEVALMVQERFGKSLLELGGNNAIIAFEDADLSLVVPSVLFAAVGTAGQRCTTVRRLFLHESIHNEVVDRLRSAYSQIRVGNPWDPNILYGPLHTKQAVSMFVRAVEEAKKQGGTVVYGGKVMDHPGNYVEPTIVTGLAHDAPIVHQETFAPILYVFKFQDEEEVFEWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSTSLPLAQGIKFQ

Gene Information

Entrez Gene ID
110695
Gene Name
aldehyde dehydrogenase family 7, member A1
Gene Symbol
Aldh7a1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005739 IDA:MGI C mitochondrion
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0004043 IEA:UniProtKB-EC F L-aminoadipate-semialdehyde dehydrogenase activity
GO:0008802 IEA:UniProtKB-EC F betaine-aldehyde dehydrogenase activity
GO:0019285 IEA:UniProtKB-UniPathway P glycine betaine biosynthetic process from choline

KEGG Pathway Links

KEGG Pathway ID Description
mmu01230 Biosynthesis of amino acids
mmu00260 Glycine, serine and threonine metabolism
mmu00010 Glycolysis / Gluconeogenesis

Domain Information

InterPro Annotations

Accession Description
IPR016162 Aldehyde dehydrogenase N-terminal domain
IPR015590 Aldehyde dehydrogenase domain
IPR016163 Aldehyde dehydrogenase, C-terminal
IPR029510 Aldehyde dehydrogenase, glutamic acid active site
IPR016161 Aldehyde/histidinol dehydrogenase

UniProt Annotations

Entry Information

Gene Name
aldehyde dehydrogenase family 7, member A1
Protein Entry
AL7A1_MOUSE
UniProt ID
Q9DBF1
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9DBF1-1; Sequence=Displayed; Name=2; IsoId=Q9DBF1-2; Sequence=VSP_038989;
Catalytic Activity (S)-2-amino-6-oxohexanoate + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H.
Catalytic Activity An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
Catalytic Activity Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.
Function Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity). {ECO:0000250}.
Pathway Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Sequence Caution Sequence=AAH12407.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the aldehyde dehydrogenase family. {ECO:0000305}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:20207735}. Nucleus {ECO:0000269|PubMed:20207735}. Cytoplasm, cytosol {ECO:0000269|PubMed:20207735}.
Subunit Homotetramer. {ECO:0000250|UniProtKB:P83402}.
Tissue Specificity Present in liver, kidney, brain and pancreas, and at lower levels in jejunum, duodenum, stomach and testes (at protein level). {ECO:0000269|PubMed:20207735}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002099 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
188219757 RefSeq NP_613066 539 alpha-aminoadipic semialdehyde dehydrogenase isoform a
188035915 RefSeq NP_001120810 511 alpha-aminoadipic semialdehyde dehydrogenase isoform b

Identical Sequences to LMP002099 proteins

Reference Database Accession Length Protein Name
GI:188035915 DBBJ BAB23726.1 511 unnamed protein product [Mus musculus]
GI:188219757 DBBJ BAE40971.1 539 unnamed protein product [Mus musculus]
GI:188035915 GenBank AAH12407.1 511 Aldh7a1 protein [Mus musculus]
GI:188219757 SwissProt Q9DBF1.4 539 RecName: Full=Alpha-aminoadipic semialdehyde dehydrogenase; Short=Alpha-AASA dehydrogenase; AltName: Full=Aldehyde dehydrogenase family 7 member A1; AltName: Full=Antiquitin-1; AltName: Full=Betaine aldehyde dehydrogenase; AltName: Full=Delta1-piperideine-6-carboxylate dehydrogenase; Short=P6c dehydrogenase; Flags: Precursor [Mus musculus]

Related Sequences to LMP002099 proteins

Reference Database Accession Length Protein Name
GI:188219757 DBBJ BAB23726.1 511 unnamed protein product [Mus musculus]
GI:188035915 DBBJ BAE40971.1 539 unnamed protein product [Mus musculus]
GI:188035915 DBBJ BAE35641.1 511 unnamed protein product [Mus musculus]
GI:188035915 DBBJ BAE26715.1 511 unnamed protein product [Mus musculus]
GI:188219757 GenBank AAH12407.1 511 Aldh7a1 protein [Mus musculus]
GI:188219757 GenBank EDM14489.1 539 aldehyde dehydrogenase family 7, member A1, isoform CRA_b [Rattus norvegicus]
GI:188219757 RefSeq NP_001120810.1 511 alpha-aminoadipic semialdehyde dehydrogenase isoform b [Mus musculus]
GI:188035915 RefSeq NP_613066.2 539 alpha-aminoadipic semialdehyde dehydrogenase isoform a [Mus musculus]
GI:188035915 RefSeq NP_001258034.1 539 alpha-aminoadipic semialdehyde dehydrogenase [Rattus norvegicus]
GI:188219757 RefSeq NP_001258034.1 539 alpha-aminoadipic semialdehyde dehydrogenase [Rattus norvegicus]
GI:188219757 SwissProt Q64057.2 539 RecName: Full=Alpha-aminoadipic semialdehyde dehydrogenase; Short=Alpha-AASA dehydrogenase; AltName: Full=Aldehyde dehydrogenase family 7 member A1; AltName: Full=Antiquitin-1; AltName: Full=Betaine aldehyde dehydrogenase; AltName: Full=Delta1-piperideine-6-carboxylate dehydrogenase; Short=P6c dehydrogenase; Flags: Precursor [Rattus norvegicus]
GI:188035915 SwissProt Q9DBF1.4 539 RecName: Full=Alpha-aminoadipic semialdehyde dehydrogenase; Short=Alpha-AASA dehydrogenase; AltName: Full=Aldehyde dehydrogenase family 7 member A1; AltName: Full=Antiquitin-1; AltName: Full=Betaine aldehyde dehydrogenase; AltName: Full=Delta1-piperideine-6-carboxylate dehydrogenase; Short=P6c dehydrogenase; Flags: Precursor [Mus musculus]