Gene/Proteome Database (LMPD)

LMPD ID
LMP002101
Gene ID
284098
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class W
Gene Symbol
PIGW
Synonyms
Gwt1; HPMRS5
Alternate Names
phosphatidylinositol-glycan biosynthesis class W protein; PIG-W; phosphatidylinositol glycan, class W
Chromosome
17
Map Location
17q12
EC Number
2.3.-.-
Summary
Glycosylphosphatidylinositol (GPI) is a complex glycolipid that anchors many proteins to the cell surface. PIGW acts in the third step of GPI biosynthesis and acylates the inositol ring of phosphatidylinositol (Murakami et al., 2003 [PubMed 14517336]).[supplied by OMIM, Mar 2008]
Orthologs
View orthologs and multiple alignments for PIGW

Proteins

phosphatidylinositol-glycan biosynthesis class W protein
Refseq ID NP_848612
Protein GI 75750492
UniProt ID Q7Z7B1
mRNA ID NM_178517
Length 504
RefSeq Status VALIDATED
MSEKQMKEAFVSNLNGTTVLEITQGLCFPAFCILCRGFLIIFSQYLCSFSPTWKTRFLTDFVVLIVPMVATLTIWASFILLELLGVIIFGAGLLYQIYRRRTCYARLPFLKILEKFLNISLESEYNPAISCFRVITSAFTAIAILAVDFPLFPRRFAKTELYGTGAMDFGVGGFVFGSAMVCLEVRRRKYMEGSKLHYFTNSLYSVWPLVFLGIGRLAIIKSIGYQEHLTEYGVHWNFFFTIIVVKLITPLLLIIFPLNKSWIIALGITVLYQLALDFTSLKRLILYGTDGSGTRVGLLNANREGIISTLGYVAIHMAGVQTGLYMHKNRSHIKDLIKVACFLLLAAISLFISLYVVQVNVEAVSRRMANLAFCIWIVASSLILLSSLLLGDIILSFAKFLIKGALVPCSWKLIQSPVTNKKHSESLVPEAERMEPSLCLITALNRKQLIFFLLSNITTGLINLMVDTLHSSTLWALFVVNLYMFSNCLIVYVLYLQDKTVQFW

Gene Information

Entrez Gene ID
284098
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class W
Gene Symbol
PIGW
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016746 IEA:UniProtKB-KW F transferase activity, transferring acyl groups
GO:0006501 TAS:Reactome P C-terminal protein lipidation
GO:0044267 TAS:Reactome P cellular protein metabolic process
GO:0043687 TAS:Reactome P post-translational protein modification
GO:0016254 TAS:Reactome P preassembly of GPI anchor in ER membrane

KEGG Pathway Links

KEGG Pathway ID Description
hsa00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
hsa01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_952 Synthesis of glycosylphosphatidylinositol (GPI)

Domain Information

InterPro Annotations

Accession Description
IPR009447 GWT1

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol glycan anchor biosynthesis, class W
Protein Entry
PIGW_HUMAN
UniProt ID
Q7Z7B1
Species
Human

Comments

Comment Type Description
Function Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI- anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins (By similarity).
Pathway Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Similarity Belongs to the PIGW family.
Subcellular Location Endoplasmic reticulum membrane {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP002101 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
75750492 RefSeq NP_848612 504 phosphatidylinositol-glycan biosynthesis class W protein

Identical Sequences to LMP002101 proteins

Reference Database Accession Length Protein Name
GI:75750492 GenBank AAI60092.1 504 Phosphatidylinositol glycan anchor biosynthesis, class W [synthetic construct]
GI:75750492 GenBank AAI72479.1 504 Phosphatidylinositol glycan anchor biosynthesis, class W [synthetic construct]
GI:75750492 RefSeq XP_005257295.1 504 PREDICTED: phosphatidylinositol-glycan biosynthesis class W protein isoform X2 [Homo sapiens]
GI:75750492 RefSeq XP_006721894.1 504 PREDICTED: phosphatidylinositol-glycan biosynthesis class W protein isoform X3 [Homo sapiens]
GI:75750492 RefSeq XP_006725380.1 504 PREDICTED: phosphatidylinositol-glycan biosynthesis class W protein isoform X1 [Homo sapiens]
GI:75750492 RefSeq XP_006725381.1 504 PREDICTED: phosphatidylinositol-glycan biosynthesis class W protein isoform X2 [Homo sapiens]

Related Sequences to LMP002101 proteins

Reference Database Accession Length Protein Name
GI:75750492 DBBJ BAC04413.1 504 unnamed protein product [Homo sapiens]
GI:75750492 GenBank ABP27746.1 504 Sequence 2761 from patent US 7193069
GI:75750492 GenBank JAA11878.1 504 phosphatidylinositol glycan anchor biosynthesis, class W [Pan troglodytes]
GI:75750492 GenBank JAA23707.1 504 phosphatidylinositol glycan anchor biosynthesis, class W [Pan troglodytes]
GI:75750492 GenBank JAA23708.1 504 phosphatidylinositol glycan anchor biosynthesis, class W [Pan troglodytes]
GI:75750492 GenBank JAA33364.1 504 phosphatidylinositol glycan anchor biosynthesis, class W [Pan troglodytes]