Gene/Proteome Database (LMPD)
LMPD ID
LMP002106
Gene ID
Species
Homo sapiens (Human)
Gene Name
phospholipase C, beta 3 (phosphatidylinositol-specific)
Gene Symbol
Synonyms
-
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; PLC beta 3; PLC-beta-3; phosphoinositide phospholipase C-beta-3
Chromosome
11
Map Location
11q13
EC Number
3.1.4.11
Summary
This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Orthologs
Proteins
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform 1 | |
|---|---|
| Refseq ID | NP_000923 |
| Protein GI | 11386139 |
| UniProt ID | Q01970 |
| mRNA ID | NM_000932 |
| Length | 1234 |
| RefSeq Status | REVIEWED |
| MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNMEVDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNFMAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDSAGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGDEGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQLGSQPSSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTPLDELRGHKALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVEDTKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQFKRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPEGLGDGPLVACASNGHAPGSSGHLSGADSESQEENTQL | |
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform 2 | |
|---|---|
| Refseq ID | NP_001171812 |
| Protein GI | 296531339 |
| UniProt ID | Q01970 |
| mRNA ID | NM_001184883 |
| Length | 1167 |
| RefSeq Status | REVIEWED |
| MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEEKLMTVVSGPDPVNTVFLNFMAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDSAGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGDEGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQLGSQPSSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTPLDELRGHKALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVEDTKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQFKRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPEGLGDGPLVACASNGHAPGSSGHLSGADSESQEENTQL | |
Gene Information
Entrez Gene ID
Gene Name
phospholipase C, beta 3 (phosphatidylinositol-specific)
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0016020 | IEA:UniProtKB-KW | C | membrane |
| GO:0005634 | IDA:HPA | C | nucleus |
| GO:0043234 | IDA:MGI | C | protein complex |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0005516 | IPI:BHF-UCL | F | calmodulin binding |
| GO:0004435 | IEA:UniProtKB-EC | F | phosphatidylinositol phospholipase C activity |
| GO:0004629 | TAS:ProtInc | F | phospholipase C activity |
| GO:0004871 | IEA:UniProtKB-KW | F | signal transducer activity |
| GO:0043647 | TAS:Reactome | P | inositol phosphate metabolic process |
| GO:0035556 | IEA:InterPro | P | intracellular signal transduction |
| GO:0016042 | IEA:UniProtKB-KW | P | lipid catabolic process |
| GO:0003073 | IDA:MGI | P | regulation of systemic arterial blood pressure |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0007268 | TAS:Reactome | P | synaptic transmission |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR028390 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 |
| IPR000008 | C2 domain |
| IPR011992 | EF-hand domain pair |
| IPR016280 | Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta |
| IPR009535 | Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta, conserved site |
| IPR001192 | Phosphoinositide phospholipase C family |
| IPR000909 | Phospholipase C, phosphatidylinositol-specific , X domain |
| IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
| IPR015359 | Phospholipase C, phosphoinositol-specific, EF-hand-like |
| IPR014815 | PLC-beta, C-terminal |
| IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain |
| IPR011993 | Pleckstrin homology-like domain |
UniProt Annotations
Entry Information
Gene Name
phospholipase C, beta 3 (phosphatidylinositol-specific)
Protein Entry
PLCB3_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q01970-1; Sequence=Displayed; Name=2; IsoId=Q01970-2; Sequence=VSP_046054; Note=No experimental confirmation available.; |
| Catalytic Activity | 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. |
| Cofactor | Name=Ca(2+); Xref=ChEBI |
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. |
| Sequence Caution | Sequence=AAH32659.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; |
| Similarity | Contains 1 C2 domain. {ECO |
| Similarity | Contains 1 PI-PLC X-box domain. {ECO |
| Similarity | Contains 1 PI-PLC Y-box domain. {ECO |
| Subcellular Location | Membrane; Peripheral membrane protein. |
| Subunit | Interacts with SHANK2 (By similarity). Interacts with LPAR2. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002106 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 11386139 | RefSeq | NP_000923 | 1234 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform 1 |
| 296531339 | RefSeq | NP_001171812 | 1167 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform 2 |
Identical Sequences to LMP002106 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:11386139 | EMBL | CBU87762.1 | 1234 | unnamed protein product [Homo sapiens] |
| GI:11386139 | EMBL | CBU96709.1 | 1234 | unnamed protein product [Homo sapiens] |
| GI:296531339 | GenBank | EAW74231.1 | 1167 | phospholipase C, beta 3 (phosphatidylinositol-specific), isoform CRA_b [Homo sapiens] |
| GI:11386139 | GenBank | AED62136.1 | 1234 | Sequence 18 from patent US 7902154 |
| GI:11386139 | GenBank | AGX54697.1 | 1234 | Sequence 9750 from patent US 8541208 |
| GI:11386139 | GenBank | AGX64137.1 | 1234 | Sequence 28384 from patent US 8541208 |
| GI:11386139 | RefSeq | XP_005274109.1 | 1234 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [Homo sapiens] |
Related Sequences to LMP002106 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:296531339 | DBBJ | BAG10887.1 | 1234 | phospholipase B, delta 3, partial [synthetic construct] |
| GI:296531339 | GenBank | AAH32659.1 | 1191 | Similar to phospholipase C, beta 3 (phosphatidylinositol-specific), partial [Homo sapiens] |
| GI:296531339 | GenBank | EAW74230.1 | 1234 | phospholipase C, beta 3 (phosphatidylinositol-specific), isoform CRA_a [Homo sapiens] |
| GI:296531339 | GenBank | AED62136.1 | 1234 | Sequence 18 from patent US 7902154 |
| GI:11386139 | GenBank | JAA04641.1 | 1234 | phospholipase C, beta 3 (phosphatidylinositol-specific) [Pan troglodytes] |
| GI:11386139 | GenBank | JAA16357.1 | 1234 | phospholipase C, beta 3 (phosphatidylinositol-specific) [Pan troglodytes] |
| GI:11386139 | GenBank | JAA28799.1 | 1234 | phospholipase C, beta 3 (phosphatidylinositol-specific) [Pan troglodytes] |
| GI:11386139 | RefSeq | XP_003274203.1 | 1234 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [Nomascus leucogenys] |
| GI:11386139 | RefSeq | XP_003313091.1 | 1234 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [Pan troglodytes] |
| GI:11386139 | RefSeq | XP_003828610.1 | 1234 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [Pan paniscus] |
| GI:296531339 | RefSeq | XP_005577489.1 | 1167 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X3 [Macaca fascicularis] |
| GI:296531339 | SwissProt | Q01970.2 | 1234 | RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; AltName: Full=Phosphoinositide phospholipase C-beta-3; AltName: Full=Phospholipase C-beta-3; Short=PLC-beta-3 [Homo sapiens] |