Gene/Proteome Database (LMPD)

LMPD ID
LMP002122
Gene ID
11332
Species
Homo sapiens (Human)
Gene Name
acyl-CoA thioesterase 7
Gene Symbol
ACOT7
Synonyms
ACH1; ACT; BACH; CTE-II; LACH; LACH1; hBACH
Alternate Names
cytosolic acyl coenzyme A thioester hydrolase; CTE-IIa; acyl-CoA thioesterase 2; brain acyl CoA hydrolase; brain acyl-CoA hydrolase; acyl-CoA thioesterase, long chain; long chain acyl-CoA thioester hydrolase
Chromosome
1
Map Location
1p36
EC Number
3.1.2.2
Summary
This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for ACOT7

Proteins

cytosolic acyl coenzyme A thioester hydrolase isoform hBACHa
Refseq ID NP_009205
Protein GI 75709208
UniProt ID O00154
mRNA ID NM_007274
Length 370
RefSeq Status REVIEWED
MARPGLIHSAPGLPDTCALLQPPAASAAAAPSMSGPDVETPSAIQICRIMRPDDANVAGNVHGGTILKMIEEAGAIISTRHCNSQNGERCVAALARVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVNVMSENILTGAKKLTNKATLWYVPLSLKNVDKVLEVPPVVYSRQEQEEEGRKRYEAQKLERMETKWRNGDIVQPVLNPEPNTVSYSQSSLIHLVGPSDCTLHGFVHGGVTMKLMDEVAGIVAARHCKTNIVTASVDAINFHDKIRKGCVITISGRMTFTSNKSMEIEVLVDADPVVDSSQKRYRAASAFFTYVSLSQEGRSLPVPQLVPETEDEKKRFEEGKGRYLQMKAKRQGHAEPQP
cytosolic acyl coenzyme A thioester hydrolase isoform hBACHb
Refseq ID NP_863654
Protein GI 32528282
UniProt ID O00154
mRNA ID NM_181864
Length 380
RefSeq Status REVIEWED
MKLLARALRLCEFGRQASSRRLVAGQGCVGPRRGCCAPVQVVGPRADLPPCGACITGRIMRPDDANVAGNVHGGTILKMIEEAGAIISTRHCNSQNGERCVAALARVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVNVMSENILTGAKKLTNKATLWYVPLSLKNVDKVLEVPPVVYSRQEQEEEGRKRYEAQKLERMETKWRNGDIVQPVLNPEPNTVSYSQSSLIHLVGPSDCTLHGFVHGGVTMKLMDEVAGIVAARHCKTNIVTASVDAINFHDKIRKGCVITISGRMTFTSNKSMEIEVLVDADPVVDSSQKRYRAASAFFTYVSLSQEGRSLPVPQLVPETEDEKKRFEEGKGRYLQMKAKRQGHAEPQP
cytosolic acyl coenzyme A thioester hydrolase isoform hBACHc
Refseq ID NP_863655
Protein GI 32528284
UniProt ID O00154
mRNA ID NM_181865
Length 350
RefSeq Status REVIEWED
MLLLRRSLSLNVLRKEVDRACFGEKAKQIMRPDDANVAGNVHGGTILKMIEEAGAIISTRHCNSQNGERCVAALARVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVNVMSENILTGAKKLTNKATLWYVPLSLKNVDKVLEVPPVVYSRQEQEEEGRKRYEAQKLERMETKWRNGDIVQPVLNPEPNTVSYSQSSLIHLVGPSDCTLHGFVHGGVTMKLMDEVAGIVAARHCKTNIVTASVDAINFHDKIRKGCVITISGRMTFTSNKSMEIEVLVDADPVVDSSQKRYRAASAFFTYVSLSQEGRSLPVPQLVPETEDEKKRFEEGKGRYLQMKAKRQGHAEPQP
cytosolic acyl coenzyme A thioester hydrolase isoform hBACHd
Refseq ID NP_863656
Protein GI 32528286
UniProt ID O00154
mRNA ID NM_181866
Length 329
RefSeq Status REVIEWED
MAFQLSRIMRPDDANVAGNVHGGTILKMIEEAGAIISTRHCNSQNGERCVAALARVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVNVMSENILTGAKKLTNKATLWYVPLSLKNVDKVLEVPPVVYSRQEQEEEGRKRYEAQKLERMETKWRNGDIVQPVLNPEPNTVSYSQSSLIHLVGPSDCTLHGFVHGGVTMKLMDEVAGIVAARHCKTNIVTASVDAINFHDKIRKGCVITISGRMTFTSNKSMEIEVLVDADPVVDSSQKRYRAASAFFTYVSLSQEGRSLPVPQLVPETEDEKKRFEEGKGRYLQMKAKRQGHAEPQP

Gene Information

Entrez Gene ID
11332
Gene Name
acyl-CoA thioesterase 7
Gene Symbol
ACOT7
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0044297 IEA:Ensembl C cell body
GO:0005737 IDA:HPA C cytoplasm
GO:0005829 IDA:BHF-UCL C cytosol
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0043005 IEA:Ensembl C neuron projection
GO:0005634 IDA:HPA C nucleus
GO:0052689 IEA:UniProtKB-KW F carboxylic ester hydrolase activity
GO:0000062 IDA:BHF-UCL F fatty-acyl-CoA binding
GO:0036042 IDA:BHF-UCL F long-chain fatty acyl-CoA binding
GO:0016290 IDA:BHF-UCL F palmitoyl-CoA hydrolase activity
GO:0042803 IPI:BHF-UCL F protein homodimerization activity
GO:0015937 IDA:BHF-UCL P coenzyme A biosynthetic process
GO:0009062 IEA:Ensembl P fatty acid catabolic process
GO:0036116 IDA:BHF-UCL P long-chain fatty-acyl-CoA catabolic process
GO:0051792 IDA:BHF-UCL P medium-chain fatty acid biosynthetic process
GO:0036114 IDA:BHF-UCL P medium-chain fatty-acyl-CoA catabolic process
GO:1900535 IDA:BHF-UCL P palmitic acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa01040 Biosynthesis of unsaturated fatty acids
ko01040 Biosynthesis of unsaturated fatty acids
hsa00062 Fatty acid elongation
ko00062 Fatty acid elongation

Domain Information

InterPro Annotations

Accession Description
IPR029069 HotDog domain
IPR006683 Thioesterase superfamily

UniProt Annotations

Entry Information

Gene Name
acyl-CoA thioesterase 7
Protein Entry
BACH_HUMAN
UniProt ID
O00154
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=7; Name=1; Synonyms=B, HBACHb; IsoId=O00154-1; Sequence=Displayed; Name=2; Synonyms=A-X, hBACHa-X; IsoId=O00154-2; Sequence=VSP_000152, VSP_000155, VSP_000156; Name=3; Synonyms=A-Xi, hBACHa-Xi; IsoId=O00154-3; Sequence=VSP_000152, VSP_000154; Name=4; Synonyms=A, hBACHa; IsoId=O00154-4; Sequence=VSP_000152; Note=Major isoform.; Name=5; Synonyms=C, hBACHc; IsoId=O00154-5; Sequence=VSP_000151; Name=6; Synonyms=D, hBACHd; IsoId=O00154-6; Sequence=VSP_000153; Name=7; IsoId=O00154-7; Sequence=VSP_047094;
Catalytic Activity Palmitoyl-CoA + H(2)O = CoA + palmitate.
Domain Both hydrolase domains are required for efficient activity.
Function Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl- CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA.
Sequence Caution Sequence=AAB61211.1; Type=Frameshift; Positions=371; Evidence= ; Sequence=AAH17365.2; Type=Erroneous initiation; Evidence= ; Sequence=CAI19435.1; Type=Erroneous initiation; Evidence= ; Sequence=CAI19774.1; Type=Erroneous initiation; Evidence= ;
Similarity Contains 2 acyl coenzyme A hydrolase domains.
Subcellular Location Isoform 1: Mitochondrion.
Subcellular Location Isoform 4: Cytoplasm.
Subcellular Location Isoform 5: Mitochondrion.
Subcellular Location Isoform 6: Cytoplasm.
Subunit Homohexamer.
Tissue Specificity Isoform 4 is expressed exclusively in brain.

Identical and Related Proteins

Unique RefSeq proteins for LMP002122 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
75709208 RefSeq NP_009205 370 cytosolic acyl coenzyme A thioester hydrolase isoform hBACHa
32528282 RefSeq NP_863654 380 cytosolic acyl coenzyme A thioester hydrolase isoform hBACHb
32528284 RefSeq NP_863655 350 cytosolic acyl coenzyme A thioester hydrolase isoform hBACHc
32528286 RefSeq NP_863656 329 cytosolic acyl coenzyme A thioester hydrolase isoform hBACHd

Identical Sequences to LMP002122 proteins

Reference Database Accession Length Protein Name
GI:32528282 DBBJ BAF82786.1 380 unnamed protein product [Homo sapiens]
GI:32528282 GenBank EAW71528.1 380 acyl-CoA thioesterase 7, isoform CRA_b [Homo sapiens]
GI:75709208 GenBank EAW71531.1 370 acyl-CoA thioesterase 7, isoform CRA_e [Homo sapiens]
GI:75709208 GenBank ADA20896.1 370 Sequence 2720 from patent US 7608413
GI:32528284 GenBank ADA20897.1 350 Sequence 2721 from patent US 7608413
GI:32528282 GenBank ADA20898.1 380 Sequence 2722 from patent US 7608413
GI:32528286 GenBank ADA20900.1 329 Sequence 2724 from patent US 7608413
GI:32528282 GenBank ADA20901.1 380 Sequence 2725 from patent US 7608413
GI:32528286 GenBank ADA20902.1 329 Sequence 2726 from patent US 7608413
GI:32528284 GenBank ADA20903.1 350 Sequence 2727 from patent US 7608413
GI:75709208 GenBank AEN36792.1 370 Sequence 2720 from patent US 7998689
GI:32528284 GenBank AEN36793.1 350 Sequence 2721 from patent US 7998689
GI:32528282 GenBank AEN36794.1 380 Sequence 2722 from patent US 7998689
GI:32528286 GenBank AEN36796.1 329 Sequence 2724 from patent US 7998689
GI:32528282 GenBank AEN36797.1 380 Sequence 2725 from patent US 7998689
GI:32528286 GenBank AEN36798.1 329 Sequence 2726 from patent US 7998689
GI:32528284 GenBank AEN36799.1 350 Sequence 2727 from patent US 7998689
GI:75709208 GenBank JAA13537.1 370 acyl-CoA thioesterase 7 [Pan troglodytes]
GI:75709208 GenBank JAA23505.1 370 acyl-CoA thioesterase 7 [Pan troglodytes]
GI:75709208 GenBank JAA39172.1 370 acyl-CoA thioesterase 7 [Pan troglodytes]
GI:32528284 RefSeq XP_003281657.1 350 PREDICTED: cytosolic acyl coenzyme A thioester hydrolase isoform 2 [Nomascus leucogenys]
GI:32528286 RefSeq XP_003281658.1 329 PREDICTED: cytosolic acyl coenzyme A thioester hydrolase isoform 3 [Nomascus leucogenys]
GI:32528286 RefSeq XP_003822202.1 329 PREDICTED: cytosolic acyl coenzyme A thioester hydrolase isoform X3 [Pan paniscus]
GI:32528284 RefSeq XP_008973953.1 350 PREDICTED: cytosolic acyl coenzyme A thioester hydrolase isoform X2 [Pan paniscus]

Related Sequences to LMP002122 proteins

Reference Database Accession Length Protein Name
GI:75709208 DBBJ BAG51874.1 370 unnamed protein product [Homo sapiens]
GI:32528286 EMBL CAH90361.1 329 hypothetical protein [Pongo abelii]
GI:75709208 GenBank ABE15434.1 370 Sequence 2967 from patent US 6979557
GI:32528286 GenBank AFJ70367.1 329 cytosolic acyl coenzyme A thioester hydrolase isoform hBACHd [Macaca mulatta]
GI:75709208 GenBank JAA04810.1 370 acyl-CoA thioesterase 7 [Pan troglodytes]
GI:32528282 GenBank JAA13536.1 380 acyl-CoA thioesterase 7 [Pan troglodytes]
GI:32528282 GenBank JAA39173.1 380 acyl-CoA thioesterase 7 [Pan troglodytes]
GI:32528282 RefSeq XP_001156114.1 380 PREDICTED: cytosolic acyl coenzyme A thioester hydrolase isoform X1 [Pan troglodytes]
GI:32528284 RefSeq XP_002923897.1 350 PREDICTED: cytosolic acyl coenzyme A thioester hydrolase-like isoform 1 [Ailuropoda melanoleuca]
GI:32528282 RefSeq XP_003281656.1 380 PREDICTED: cytosolic acyl coenzyme A thioester hydrolase isoform 1 [Nomascus leucogenys]
GI:32528282 RefSeq XP_003822201.1 380 PREDICTED: cytosolic acyl coenzyme A thioester hydrolase isoform X1 [Pan paniscus]
GI:75709208 RefSeq XP_003891081.1 370 PREDICTED: cytosolic acyl coenzyme A thioester hydrolase isoform X2 [Papio anubis]
GI:32528284 RefSeq XP_003939670.1 350 PREDICTED: cytosolic acyl coenzyme A thioester hydrolase isoform X2 [Saimiri boliviensis boliviensis]
GI:32528284 RefSeq XP_005544982.1 390 PREDICTED: cytosolic acyl coenzyme A thioester hydrolase isoform X1 [Macaca fascicularis]
GI:32528286 RefSeq XP_005544986.1 329 PREDICTED: cytosolic acyl coenzyme A thioester hydrolase isoform X5 [Macaca fascicularis]
GI:75709208 RefSeq XP_005544988.1 370 PREDICTED: cytosolic acyl coenzyme A thioester hydrolase isoform X7 [Macaca fascicularis]
GI:32528284 RefSeq XP_006885857.1 350 PREDICTED: cytosolic acyl coenzyme A thioester hydrolase isoform X2 [Elephantulus edwardii]
GI:32528284 RefSeq XP_007940769.1 350 PREDICTED: cytosolic acyl coenzyme A thioester hydrolase isoform X2 [Orycteropus afer afer]
GI:75709208 RefSeq XP_007978965.1 370 PREDICTED: cytosolic acyl coenzyme A thioester hydrolase isoform X1 [Chlorocebus sabaeus]
GI:32528286 RefSeq XP_007978967.1 329 PREDICTED: cytosolic acyl coenzyme A thioester hydrolase isoform X3 [Chlorocebus sabaeus]
GI:32528284 RefSeq XP_007978971.1 390 PREDICTED: cytosolic acyl coenzyme A thioester hydrolase isoform X6 [Chlorocebus sabaeus]
GI:32528286 RefSeq XP_009180908.1 329 PREDICTED: cytosolic acyl coenzyme A thioester hydrolase isoform X4 [Papio anubis]
GI:32528282 RefSeq XP_009233952.1 380 PREDICTED: cytosolic acyl coenzyme A thioester hydrolase isoform X1 [Pongo abelii]
GI:32528286 RefSeq XP_010355701.1 329 PREDICTED: cytosolic acyl coenzyme A thioester hydrolase [Rhinopithecus roxellana]