Gene/Proteome Database (LMPD)

LMPD ID
LMP002131
Gene ID
1728
Species
Homo sapiens (Human)
Gene Name
NAD(P)H dehydrogenase, quinone 1
Gene Symbol
NQO1
Synonyms
DHQU; DIA4; DTD; NMOR1; NMORI; QR1
Chromosome
16
Map Location
16q22.1
EC Number
1.6.5.2
Summary
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for NQO1

Proteins

NAD(P)H dehydrogenase [quinone] 1 isoform a
Refseq ID NP_000894
Protein GI 4505415
UniProt ID P15559
mRNA ID NM_000903
Length 274
RefSeq Status REVIEWED
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
NAD(P)H dehydrogenase [quinone] 1 isoform b
Refseq ID NP_001020604
Protein GI 70995396
UniProt ID P15559
mRNA ID NM_001025433
Length 240
RefSeq Status REVIEWED
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
NAD(P)H dehydrogenase [quinone] 1 isoform c
Refseq ID NP_001020605
Protein GI 70995422
UniProt ID P15559
mRNA ID NM_001025434
Length 236
RefSeq Status REVIEWED
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
NAD(P)H dehydrogenase [quinone] 1 isoform d
Refseq ID NP_001273066
Protein GI 554790420
UniProt ID B4DLR8
mRNA ID NM_001286137
Length 202
RefSeq Status REVIEWED
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK

Gene Information

Entrez Gene ID
1728
Gene Name
NAD(P)H dehydrogenase, quinone 1
Gene Symbol
NQO1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:HPA C cytoplasm
GO:0005829 TAS:Reactome C cytosol
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0043025 IEA:Ensembl C neuronal cell body
GO:0003955 TAS:ProtInc F NAD(P)H dehydrogenase (quinone) activity
GO:0004128 TAS:ProtInc F cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0044822 IDA:UniProtKB F poly(A) RNA binding
GO:0004784 IEA:Ensembl F superoxide dismutase activity
GO:0007568 IEA:Ensembl P aging
GO:0034641 TAS:Reactome P cellular nitrogen compound metabolic process
GO:0043086 IEA:Ensembl P negative regulation of catalytic activity
GO:0006809 TAS:ProtInc P nitric oxide biosynthetic process
GO:0043525 IEA:Ensembl P positive regulation of neuron apoptotic process
GO:0006521 TAS:Reactome P regulation of cellular amino acid metabolic process
GO:0032355 IEA:Ensembl P response to estradiol
GO:0045471 IEA:Ensembl P response to ethanol
GO:0007584 IEA:Ensembl P response to nutrient
GO:0009636 TAS:ProtInc P response to toxic substance
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0007271 TAS:ProtInc P synaptic transmission, cholinergic
GO:0006805 TAS:ProtInc P xenobiotic metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR003680 Flavodoxin-like fold
IPR029039 Flavoprotein-like

UniProt Annotations

Entry Information

Gene Name
NAD(P)H dehydrogenase, quinone 1
Protein Entry
NQO1_HUMAN
UniProt ID
P15559
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P15559-1; Sequence=Displayed; Name=2; IsoId=P15559-2; Sequence=VSP_042716; Note=No experimental confirmation available.; Name=3; IsoId=P15559-3; Sequence=VSP_044446; Note=No experimental confirmation available.;
Catalytic Activity NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone.
Cofactor Name=FAD; Xref=ChEBI
Enzyme Regulation Inhibited by dicoumarol.
Function The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
Induction By dioxin.
Interaction Self; NbExp=5; IntAct=EBI-3989435, EBI-3989435; Q9UK53:ING1; NbExp=3; IntAct=EBI-3989435, EBI-399198; O88898-2:Tp63 (xeno); NbExp=2; IntAct=EBI-3989435, EBI-2338228; O88898-6:Tp63 (xeno); NbExp=2; IntAct=EBI-3989435, EBI-2338244;
Mass Spectrometry Mass=30864; Mass_error=6; Method=Electrospray; Range=2-274; Evidence= ;
Miscellaneous Quinone reductase accepts electrons from both NADH and NADPH with equal efficiency.
Polymorphism The Ser-187 polymorphism may be linked to susceptibility to forms of cancers.
Similarity Belongs to the NAD(P)H dehydrogenase (quinone) family.
Subcellular Location Cytoplasm.
Subunit Homodimer. {ECO
Web Resource Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/NQO1ID375.html";
Web Resource Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/nqo1/";

Identical and Related Proteins

Unique RefSeq proteins for LMP002131 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4505415 RefSeq NP_000894 274 NAD(P)H dehydrogenase [quinone] 1 isoform a
70995396 RefSeq NP_001020604 240 NAD(P)H dehydrogenase [quinone] 1 isoform b
70995422 RefSeq NP_001020605 236 NAD(P)H dehydrogenase [quinone] 1 isoform c
554790420 RefSeq NP_001273066 202 NAD(P)H dehydrogenase [quinone] 1 isoform d

Identical Sequences to LMP002131 proteins

Reference Database Accession Length Protein Name
GI:554790420 DBBJ BAG59630.1 202 unnamed protein product [Homo sapiens]
GI:70995396 DBBJ BAH14617.1 240 unnamed protein product [Homo sapiens]
GI:4505415 EMBL CBX47453.1 274 unnamed protein product [Homo sapiens]
GI:70995396 EMBL CBX47454.1 240 unnamed protein product [Homo sapiens]
GI:70995422 EMBL CBX47455.1 236 unnamed protein product [Homo sapiens]
GI:70995396 GenBank EAW83283.1 240 NAD(P)H dehydrogenase, quinone 1, isoform CRA_b [Homo sapiens]
GI:4505415 GenBank AED39137.1 274 Sequence 1083 from patent US 7883858
GI:4505415 GenBank AFA57513.1 274 Sequence 10 from patent US 8088574
GI:4505415 GenBank AHD76305.1 274 Sequence 19578 from patent US 8586006
GI:70995396 GenBank AHD76306.1 240 Sequence 19579 from patent US 8586006
GI:70995422 GenBank AHD76307.1 236 Sequence 19580 from patent US 8586006
GI:4505415 GenBank AHL57767.1 274 Sequence 66 from patent US 8647822
GI:70995396 GenBank AHL57768.1 240 Sequence 68 from patent US 8647822
GI:70995422 GenBank AHL57769.1 236 Sequence 70 from patent US 8647822
GI:4505415 RefSeq XP_004057936.1 274 PREDICTED: NAD(P)H dehydrogenase [quinone] 1 isoform 1 [Gorilla gorilla gorilla]
GI:70995396 RefSeq XP_004057937.1 240 PREDICTED: NAD(P)H dehydrogenase [quinone] 1 isoform 2 [Gorilla gorilla gorilla]
GI:70995422 RefSeq XP_004057938.1 236 PREDICTED: NAD(P)H dehydrogenase [quinone] 1 isoform 3 [Gorilla gorilla gorilla]

Related Sequences to LMP002131 proteins

Reference Database Accession Length Protein Name
GI:70995396 DBBJ BAG35286.1 274 unnamed protein product [Homo sapiens]
GI:70995422 DBBJ BAG60289.1 236 unnamed protein product [Homo sapiens]
GI:70995396 EMBL CBX51347.1 274 unnamed protein product [Homo sapiens]
GI:554790420 EMBL CBX47455.1 236 unnamed protein product [Homo sapiens]
GI:4505415 GenBank AAV38758.1 275 NAD(P)H dehydrogenase, quinone 1, partial [synthetic construct]
GI:4505415 GenBank AAX42729.1 275 NAD(P)H dehydrogenase quninone 1, partial [synthetic construct]
GI:70995422 GenBank AAI07740.1 240 NQO1 protein, partial [Homo sapiens]
GI:70995396 GenBank EAW83284.1 274 NAD(P)H dehydrogenase, quinone 1, isoform CRA_c [Homo sapiens]
GI:70995396 GenBank AED39137.1 274 Sequence 1083 from patent US 7883858
GI:70995396 GenBank AFA57513.1 274 Sequence 10 from patent US 8088574
GI:4505415 GenBank JAA07332.1 320 NAD(P)H dehydrogenase, quinone 1 [Pan troglodytes]
GI:4505415 GenBank JAA07333.1 320 NAD(P)H dehydrogenase, quinone 1 [Pan troglodytes]
GI:70995422 GenBank JAA07334.1 282 NAD(P)H dehydrogenase, quinone 1 [Pan troglodytes]
GI:554790420 GenBank JAA07334.1 282 NAD(P)H dehydrogenase, quinone 1 [Pan troglodytes]
GI:70995422 GenBank JAA31263.1 236 NAD(P)H dehydrogenase, quinone 1 [Pan troglodytes]
GI:4505415 GenBank JAA36804.1 274 NAD(P)H dehydrogenase, quinone 1 [Pan troglodytes]
GI:4505415 GenBank JAA36805.1 274 NAD(P)H dehydrogenase, quinone 1 [Pan troglodytes]
GI:70995422 GenBank JAA36806.1 236 NAD(P)H dehydrogenase, quinone 1 [Pan troglodytes]
GI:554790420 GenBank AHD76307.1 236 Sequence 19580 from patent US 8586006
GI:554790420 GenBank AHL57769.1 236 Sequence 70 from patent US 8647822
GI:554790420 RefSeq NP_001020605.1 236 NAD(P)H dehydrogenase [quinone] 1 isoform c [Homo sapiens]
GI:70995396 RefSeq XP_523404.3 240 PREDICTED: NAD(P)H dehydrogenase [quinone] 1 [Pan troglodytes]
GI:554790420 RefSeq XP_004057938.1 236 PREDICTED: NAD(P)H dehydrogenase [quinone] 1 isoform 3 [Gorilla gorilla gorilla]
GI:70995422 RefSeq XP_005592449.1 236 PREDICTED: NAD(P)H dehydrogenase [quinone] 1 isoform X3 [Macaca fascicularis]