Gene/Proteome Database (LMPD)

LMPD ID
LMP002137
Gene ID
94226
Species
Mus musculus (Mouse)
Gene Name
sphingosine-1-phosphate receptor 5
Gene Symbol
S1pr5
Synonyms
Edg8; S1P5; lpB4
Alternate Names
sphingosine 1-phosphate receptor 5; S1P receptor 5; S1P receptor Edg-8; lysophospholipid receptor B4; sphingosine-1-phosphate receptor LPB4; sphingosine 1-phosphate receptor Edg-8; endothelial differentiation G-protein-coupled receptor 8; endothelial differentiation, sphingolipid G-protein-coupled receptor, 8
Chromosome
9
Map Location
9|9 A4

Proteins

sphingosine 1-phosphate receptor 5
Refseq ID NP_444420
Protein GI 16716489
UniProt ID Q91X56
mRNA ID NM_053190
Length 400
RefSeq Status VALIDATED
MEPGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAAVCLAVCAFIVLENLAVLLVLVRHPRFHAPMFLLLGSLTLSDLLAGAAYATNILLSGPLTLRLSPALWFAREGGVFVALAASVLSLLAIALERHLTMARRGPAPAASRARTLAMAVAAWGASLLLGLLPALGWNCLGRLETCSTVLPLYAKAYVLFCVLAFLGILAAICALYARIYCQVRANARRLRAGPGSRRATSSSRSRHTPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARACPVLLQADPFLGLAMANSLLNPIIYTFTNRDLRHALLRLLCCGRGPCNQDSSNSLQRSPSAAGPSGGGLRRCLPPTLDRSSSPSEHLSPQQDGVDTSCSTGSPGVATANRSLVPTATD

Gene Information

Entrez Gene ID
94226
Gene Name
sphingosine-1-phosphate receptor 5
Gene Symbol
S1pr5
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 TAS:MGI C plasma membrane
GO:0004930 TAS:MGI F G-protein coupled receptor activity
GO:0038036 IEA:InterPro F sphingosine-1-phosphate receptor activity
GO:0007186 TAS:MGI P G-protein coupled receptor signaling pathway
GO:0045664 IEA:Ensembl P regulation of neuron differentiation

REACTOME Pathway Links

REACTOME Pathway ID Description
5893663 G alpha (i) signalling events
5893755 Lysosphingolipid and LPA receptors

Domain Information

InterPro Annotations

Accession Description
IPR005386 EDG-8 sphingosine 1-phosphate receptor
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR004061 Sphingosine 1-phosphate receptor

UniProt Annotations

Entry Information

Gene Name
sphingosine-1-phosphate receptor 5
Protein Entry
S1PR5_MOUSE
UniProt ID
Q91X56
Species
Mouse

Comments

Comment Type Description
Developmental Stage Expressed in 7-day and 17-day embryos, but not in 11-day and 15-day embryos, implying its role in mammalian development. In oligodendrocytes, expressed throughout development from the immature stages to the mature myelin-froming cell. {ECO:0000269|PubMed:15703400}.
Function Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. S1P activation on O4-positive pre-oligodendrocytes induces process retraction via a Rho kinase/collapsin response-mediated protein signaling pathway. The S1P-induced survival of mature oligodendrocytes is mediated through a pertussis toxin-sensitive, Akt-dependent pathway. S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. These effects depend on the developmental stage of the cell. {ECO:0000250, ECO:0000269|PubMed:15703400}.
Similarity Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Expressed in spleen and brain. In the CNS expression is restricted to oligodendrocytes. {ECO:0000269|PubMed:11705398, ECO:0000269|PubMed:15703400}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002137 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16716489 RefSeq NP_444420 400 sphingosine 1-phosphate receptor 5

Identical Sequences to LMP002137 proteins

Reference Database Accession Length Protein Name
GI:16716489 GenBank AAH12232.1 400 Sphingosine-1-phosphate receptor 5 [Mus musculus]
GI:16716489 GenBank EDL25171.1 400 endothelial differentiation, sphingolipid G-protein-coupled receptor, 8 [Mus musculus]
GI:16716489 SwissProt Q91X56.1 400 RecName: Full=Sphingosine 1-phosphate receptor 5; Short=S1P receptor 5; Short=S1P5; AltName: Full=Endothelial differentiation G-protein-coupled receptor 8; AltName: Full=Lysophospholipid receptor B4; AltName: Full=Sphingosine 1-phosphate receptor Edg-8; Short=S1P receptor Edg-8 [Mus musculus]

Related Sequences to LMP002137 proteins

Reference Database Accession Length Protein Name
GI:16716489 GenBank EDL78311.1 400 endothelial differentiation, sphingolipid G-protein-coupled receptor, 8, isoform CRA_a [Rattus norvegicus]
GI:16716489 GenBank EDL78312.1 400 endothelial differentiation, sphingolipid G-protein-coupled receptor, 8, isoform CRA_a [Rattus norvegicus]
GI:16716489 RefSeq XP_006242725.1 400 PREDICTED: sphingosine 1-phosphate receptor 5 isoform X1 [Rattus norvegicus]
GI:16716489 RefSeq XP_006242726.1 400 PREDICTED: sphingosine 1-phosphate receptor 5 isoform X1 [Rattus norvegicus]
GI:16716489 RefSeq XP_006242727.1 400 PREDICTED: sphingosine 1-phosphate receptor 5 isoform X1 [Rattus norvegicus]
GI:16716489 SwissProt Q9JKM5.1 400 RecName: Full=Sphingosine 1-phosphate receptor 5; Short=S1P receptor 5; Short=S1P5; AltName: Full=Endothelial differentiation G-protein-coupled receptor 8; AltName: Full=Nerve growth factor-regulated G-protein-coupled receptor 1; Short=NRG-1; AltName: Full=Sphingosine 1-phosphate receptor Edg-8; Short=S1P receptor Edg-8 [Rattus norvegicus]