Gene/Proteome Database (LMPD)

LMPD ID
LMP002154
Gene ID
26377
Species
Mus musculus (Mouse)
Gene Name
dual adaptor for phosphotyrosine and 3-phosphoinositides 1
Gene Symbol
Dapp1
Synonyms
Bam32
Chromosome
3
Map Location
3 H2|3

Proteins

dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
Refseq ID NP_036062
Protein GI 6753604
UniProt ID Q3TEK6
mRNA ID NM_011932
Length 280
RefSeq Status VALIDATED
MGRAELLGGNMSTQDPSELWGRADGGTDLLQDLGWYHGNLTRHAAEALLLSNGRDGSYLLRDSNEQTGLYSLSVRAKDSVKHFHVEYTGYSFKFGFNEYSSLKDFVKHFANQPLIGSETGTLMVLKHPYPREVEEPCIYESVRVHTAMQTGRTENDLVPTAPSLGTKEGYLTKQGGLVKTWKTRWFTLQRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERVNCFCLVFPFRTFYLCAKTGVEADEWIKILRWKLSKIRKQLDQGEDTVRSRSFIFK

Gene Information

Entrez Gene ID
26377
Gene Name
dual adaptor for phosphotyrosine and 3-phosphoinositides 1
Gene Symbol
Dapp1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005942 IEA:InterPro C phosphatidylinositol 3-kinase complex
GO:0005886 IEA:Ensembl C plasma membrane
GO:0035014 IEA:InterPro F phosphatidylinositol 3-kinase regulator activity
GO:0005547 IEA:Ensembl F phosphatidylinositol-3,4,5-trisphosphate binding
GO:0043325 IEA:Ensembl F phosphatidylinositol-3,4-bisphosphate binding

KEGG Pathway Links

KEGG Pathway ID Description
ko04662 B cell receptor signaling pathway
mmu04662 B cell receptor signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5892925 Adaptive Immune System
5892923 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
5892920 Immune System
5892924 Signaling by the B Cell Receptor (BCR)

Domain Information

InterPro Annotations

Accession Description
IPR001720 PI3 kinase, P85 regulatory subunit
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain
IPR000980 SH2 domain

UniProt Annotations

Entry Information

Gene Name
dual adaptor for phosphotyrosine and 3-phosphoinositides 1
Protein Entry
DAPP1_MOUSE
UniProt ID
Q3TEK6
Species
Mouse

Comments

Comment Type Description
Function May act as a B-cell-associated adapter that regulates B- cell antigen receptor (BCR)-signaling downstream of PI3K.
Induction Upon B-cell activation. {ECO:0000250}.
Ptm Phosphorylated on tyrosine residues. {ECO:0000250}.
Similarity Contains 1 PH domain.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Similarity Contains 1 SH2 domain. {ECO:0000255|PROSITE- ProRule:PRU00191}.
Subcellular Location Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Membrane-associated after cell stimulation leading to its translocation. {ECO:0000250}.
Subunit Interacts with PtdIns(3,4,5)P3 and PLCG2. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002154 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6753604 RefSeq NP_036062 280 dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

Identical Sequences to LMP002154 proteins

Reference Database Accession Length Protein Name
GI:6753604 DBBJ BAE26958.1 280 unnamed protein product [Mus musculus]
GI:6753604 GenBank AAF14579.1 280 B lymphocyte adapter protein BAM32 [Mus musculus]
GI:6753604 GenBank AAH14759.1 280 Dual adaptor for phosphotyrosine and 3-phosphoinositides 1 [Mus musculus]
GI:6753604 GenBank ABK42134.1 280 Bam32 [synthetic construct]
GI:6753604 GenBank EDL12112.1 280 dual adaptor for phosphotyrosine and 3-phosphoinositides 1 [Mus musculus]
GI:6753604 SwissProt Q9QXT1.1 280 RecName: Full=Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide; Short=mDAPP1; AltName: Full=B lymphocyte adapter protein Bam32; AltName: Full=B-cell adapter molecule of 32 kDa [Mus musculus]

Related Sequences to LMP002154 proteins

Reference Database Accession Length Protein Name
GI:6753604 DBBJ BAE26622.1 280 unnamed protein product [Mus musculus]
GI:6753604 GenBank AAD49698.1 280 adaptor protein DAPP1 [Mus musculus]
GI:6753604 GenBank EDL82303.1 279 dual adaptor for phosphotyrosine and 3-phosphoinositides 1 (predicted) [Rattus norvegicus]
GI:6753604 RefSeq NP_001102038.1 279 dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide [Rattus norvegicus]
GI:6753604 RefSeq XP_005082020.1 280 PREDICTED: dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide [Mesocricetus auratus]
GI:6753604 RefSeq XP_005357394.1 280 PREDICTED: dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide [Microtus ochrogaster]