Gene/Proteome Database (LMPD)

LMPD ID
LMP002157
Gene ID
110446
Species
Mus musculus (Mouse)
Gene Name
acetyl-Coenzyme A acetyltransferase 1
Gene Symbol
Acat1
Synonyms
6330585C21Rik; Acat
Alternate Names
acetyl-CoA acetyltransferase, mitochondrial; acetoacetyl-CoA thiolase
Chromosome
9
Map Location
9 C-D|9 29.12 cM
EC Number
2.3.1.9

Proteins

acetyl-CoA acetyltransferase, mitochondrial precursor
Refseq ID NP_659033
Protein GI 21450129
UniProt ID Q8QZT1
mRNA ID NM_144784
Length 424
RefSeq Status PROVISIONAL
MAALVALHGVVRRPLLRGLLQEVRCLERSYASKPTLNEVVIVSAIRTPIGSFLGSLASQPATKLGTAAIQGAIEKAGIPKEEVKEVYMGNVIQGGEGQAPTRQATLGAGLPISTPCTTVNKVCASGMKAIMMASQSLMCGHQDVMVAGGMESMSNVPYVMSRGATPYGGVKLEDLIVKDGLTDVYNKIHMGNCAENTAKKMNISRQEQDTYALSSYTRSKEAWDAGKFASEITPITISVKGKPDVVVKEDEEYKRVDFSKVPKLKTVFQKENGTITAANASTLNDGAAALVLMTAEAAQRLNVKPLARIAAFADAAVDPIDFPLAPAYAVPKVLKYAGLKKEDIAMWEVNEAFSVVVLANIKMLEIDPQKVNIHGGAVSLGHPIGMSGARIVVHMAHALKPGEFGLASICNGGGGASALLIEKL
transit_peptide: 1..30 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q8QZT1.1) calculated_mol_wt: 3420 peptide sequence: MAALVALHGVVRRPLLRGLLQEVRCLERSY mat_peptide: 31..424 product: Acetyl-CoA acetyltransferase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8QZT1.1) calculated_mol_wt: 41414 peptide sequence: ASKPTLNEVVIVSAIRTPIGSFLGSLASQPATKLGTAAIQGAIEKAGIPKEEVKEVYMGNVIQGGEGQAPTRQATLGAGLPISTPCTTVNKVCASGMKAIMMASQSLMCGHQDVMVAGGMESMSNVPYVMSRGATPYGGVKLEDLIVKDGLTDVYNKIHMGNCAENTAKKMNISRQEQDTYALSSYTRSKEAWDAGKFASEITPITISVKGKPDVVVKEDEEYKRVDFSKVPKLKTVFQKENGTITAANASTLNDGAAALVLMTAEAAQRLNVKPLARIAAFADAAVDPIDFPLAPAYAVPKVLKYAGLKKEDIAMWEVNEAFSVVVLANIKMLEIDPQKVNIHGGAVSLGHPIGMSGARIVVHMAHALKPGEFGLASICNGGGGASALLIEKL

Gene Information

Entrez Gene ID
110446
Gene Name
acetyl-Coenzyme A acetyltransferase 1
Gene Symbol
Acat1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005743 IDA:MGI C mitochondrial inner membrane
GO:0005759 IEA:Ensembl C mitochondrial matrix
GO:0005739 IDA:MGI C mitochondrion
GO:0003985 IDA:MGI F acetyl-CoA C-acetyltransferase activity
GO:0050662 IEA:Ensembl F coenzyme binding
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0060612 IEA:Ensembl P adipose tissue development
GO:0007420 IEA:Ensembl P brain development
GO:0001889 IEA:Ensembl P liver development
GO:0072229 IEA:Ensembl P metanephric proximal convoluted tubule development
GO:0051260 IEA:Ensembl P protein homooligomerization
GO:0009725 IEA:Ensembl P response to hormone
GO:0014070 IEA:Ensembl P response to organic cyclic compound
GO:0042594 IEA:Ensembl P response to starvation

KEGG Pathway Links

KEGG Pathway ID Description
mmu01200 Carbon metabolism
mmu00900 Terpenoid backbone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002155 Thiolase
IPR020617 Thiolase, C-terminal
IPR020616 Thiolase, N-terminal
IPR020610 Thiolase, active site
IPR020615 Thiolase, acyl-enzyme intermediate active site
IPR020613 Thiolase, conserved site
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup

UniProt Annotations

Entry Information

Gene Name
acetyl-Coenzyme A acetyltransferase 1
Protein Entry
THIL_MOUSE
UniProt ID
Q8QZT1
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 2 acetyl-CoA = CoA + acetoacetyl-CoA. {ECO:0000255|PROSITE-ProRule:PRU10020}.
Enzyme Regulation Activated by potassium ions, but not sodium ions. {ECO:0000250}.
Function Plays a major role in ketone body metabolism. {ECO:0000250}.
Ptm Succinylation at Lys-265, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5. {ECO:0000269|PubMed:23806337}.
Similarity Belongs to the thiolase family. {ECO:0000305}.
Subcellular Location Mitochondrion {ECO:0000250}.
Subunit Homotetramer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002157 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21450129 RefSeq NP_659033 424 acetyl-CoA acetyltransferase, mitochondrial precursor

Identical Sequences to LMP002157 proteins

Reference Database Accession Length Protein Name
GI:21450129 DBBJ BAC27697.1 424 unnamed protein product [Mus musculus]
GI:21450129 DBBJ BAC38304.1 424 unnamed protein product [Mus musculus]
GI:21450129 DBBJ BAE41356.1 424 unnamed protein product [Mus musculus]
GI:21450129 EMBL CAD52869.1 424 acetyl-CoA acetyltransferase, mitochondrial precursor [Mus musculus]
GI:21450129 GenBank EDL25799.1 424 acetyl-Coenzyme A acetyltransferase 1 [Mus musculus]
GI:21450129 SwissProt Q8QZT1.1 424 RecName: Full=Acetyl-CoA acetyltransferase, mitochondrial; AltName: Full=Acetoacetyl-CoA thiolase; Flags: Precursor [Mus musculus]

Related Sequences to LMP002157 proteins

Reference Database Accession Length Protein Name
GI:21450129 DBBJ BAA03016.1 424 mitochondrial acetoacetyl-CoA thiolase [Rattus norvegicus]
GI:21450129 DBBJ BAA00401.1 424 mitochondrial acetoacetyl-CoA thiolase precursor [Rattus sp.]
GI:21450129 DBBJ BAE37335.1 424 unnamed protein product [Mus musculus]
GI:21450129 GenBank EDL95520.1 424 acetyl-coenzyme A acetyltransferase 1, isoform CRA_b [Rattus norvegicus]
GI:21450129 RefSeq NP_058771.2 424 acetyl-CoA acetyltransferase, mitochondrial precursor [Rattus norvegicus]
GI:21450129 SwissProt P17764.1 424 RecName: Full=Acetyl-CoA acetyltransferase, mitochondrial; AltName: Full=Acetoacetyl-CoA thiolase; Flags: Precursor [Rattus norvegicus]