Gene/Proteome Database (LMPD)

LMPD ID
LMP002158
Gene ID
2182
Species
Homo sapiens (Human)
Gene Name
acyl-CoA synthetase long-chain family member 4
Gene Symbol
ACSL4
Synonyms
ACS4; FACL4; LACS4; MRX63; MRX68
Alternate Names
long-chain-fatty-acid--CoA ligase 4; LACS 4; acyl-CoA synthetase 4; lignoceroyl-CoA synthase; long-chain acyl-CoA synthetase 4; long-chain fatty-acid-Coenzyme A ligase 4; fatty-acid-Coenzyme A ligase, long-chain 4
Chromosome
X
Map Location
Xq22.3-q23
EC Number
6.2.1.3
Summary
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for ACSL4

Proteins

long-chain-fatty-acid--CoA ligase 4 isoform 1
Refseq ID NP_004449
Protein GI 4758332
UniProt ID O60488
mRNA ID NM_004458
Length 670
RefSeq Status REVIEWED
MAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESEASYLITSVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPEGFEIHSMQSVEELGSNPENLGIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLCNLLLFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQKRLTLLAQQKGVEGTWVDICNNPAMEAEILKEIREAANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELRNHYLKDIERMYGGK
long-chain-fatty-acid--CoA ligase 4 isoform 2
Refseq ID NP_075266
Protein GI 12669909
UniProt ID O60488
mRNA ID NM_022977
Length 711
RefSeq Status REVIEWED
MKLKLNVLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESEASYLITSVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPEGFEIHSMQSVEELGSNPENLGIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLCNLLLFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQKRLTLLAQQKGVEGTWVDICNNPAMEAEILKEIREAANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELRNHYLKDIERMYGGK

Gene Information

Entrez Gene ID
2182
Gene Name
acyl-CoA synthetase long-chain family member 4
Gene Symbol
ACSL4
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:UniProtKB C cytoplasm
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0044233 IDA:MGI C ER-mitochondrion membrane contact site
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005811 IDA:UniProtKB C lipid particle
GO:0016020 IDA:UniProtKB C membrane
GO:0005741 IEA:UniProtKB-KW C mitochondrial outer membrane
GO:0043025 IEA:Ensembl C neuronal cell body
GO:0005777 IEA:UniProtKB-KW C peroxisome
GO:0047676 IDA:UniProtKB F arachidonate-CoA ligase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004467 IDA:MGI F long-chain fatty acid-CoA ligase activity
GO:0031957 IMP:UniProtKB F very long-chain fatty acid-CoA ligase activity
GO:0044255 TAS:Reactome P cellular lipid metabolic process
GO:0060996 IEA:Ensembl P dendritic spine development
GO:0060136 IEA:Ensembl P embryonic process involved in female pregnancy
GO:0015908 IEA:Ensembl P fatty acid transport
GO:0008610 IDA:UniProtKB P lipid biosynthetic process
GO:0006629 IDA:UniProtKB P lipid metabolic process
GO:0001676 IDA:GOC P long-chain fatty acid metabolic process
GO:0035338 TAS:Reactome P long-chain fatty-acyl-CoA biosynthetic process
GO:0032307 IDA:UniProtKB P negative regulation of prostaglandin secretion
GO:0030307 IDA:UniProtKB P positive regulation of cell growth
GO:0070672 IEA:Ensembl P response to interleukin-15
GO:0007584 IEA:Ensembl P response to nutrient
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0019432 TAS:Reactome P triglyceride biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04920 Adipocytokine signaling pathway
hsa04146 Peroxisome
hsa03320 PPAR signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
acyl-CoA synthetase long-chain family member 4
Protein Entry
ACSL4_HUMAN
UniProt ID
O60488
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=O60488-1; Sequence=Displayed; Name=Short; IsoId=O60488-2; Sequence=VSP_000238;
Catalytic Activity ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor Name=Mg(2+); Xref=ChEBI
Disease Alport syndrome with mental retardation, midface hypoplasia and elliptocytosis (ATS-MR) [MIM
Disease Mental retardation, X-linked 63 (MRX63) [MIM
Function Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.
Similarity Belongs to the ATP-dependent AMP-binding enzyme family.
Subcellular Location Mitochondrion outer membrane ; Single-pass type III membrane protein . Peroxisome membrane ; Single-pass type III membrane protein {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP002158 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4758332 RefSeq NP_004449 670 long-chain-fatty-acid--CoA ligase 4 isoform 1
12669909 RefSeq NP_075266 711 long-chain-fatty-acid--CoA ligase 4 isoform 2

Identical Sequences to LMP002158 proteins

Reference Database Accession Length Protein Name
GI:4758332 DBBJ BAF84759.1 670 unnamed protein product [Homo sapiens]
GI:12669909 DBBJ BAI45580.1 711 acyl-CoA synthetase long-chain family member 4, partial [synthetic construct]
GI:12669909 GenBank EAX02671.1 711 acyl-CoA synthetase long-chain family member 4, isoform CRA_a [Homo sapiens]
GI:12669909 GenBank EAX02673.1 711 acyl-CoA synthetase long-chain family member 4, isoform CRA_a [Homo sapiens]
GI:4758332 GenBank ABM81761.1 670 acyl-CoA synthetase long-chain family member 4 [synthetic construct]
GI:4758332 GenBank AHD72049.1 670 Sequence 7547 from patent US 8586006
GI:12669909 GenBank AHD72050.1 711 Sequence 7548 from patent US 8586006
GI:4758332 GenBank AIC54374.1 670 ACSL4, partial [synthetic construct]
GI:12669909 RefSeq XP_005262165.1 711 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X1 [Homo sapiens]
GI:12669909 RefSeq XP_005262166.1 711 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X2 [Homo sapiens]
GI:4758332 RefSeq XP_005262167.1 670 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X3 [Homo sapiens]
GI:4758332 RefSeq XP_006724698.1 670 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X4 [Homo sapiens]

Related Sequences to LMP002158 proteins

Reference Database Accession Length Protein Name
GI:4758332 DBBJ BAI45580.1 711 acyl-CoA synthetase long-chain family member 4, partial [synthetic construct]
GI:4758332 GenBank EAX02673.1 711 acyl-CoA synthetase long-chain family member 4, isoform CRA_a [Homo sapiens]
GI:12669909 GenBank JAA20512.1 711 acyl-CoA synthetase long-chain family member 4 [Pan troglodytes]
GI:12669909 GenBank JAA32570.1 711 acyl-CoA synthetase long-chain family member 4 [Pan troglodytes]
GI:12669909 GenBank JAA37470.1 711 acyl-CoA synthetase long-chain family member 4 [Pan troglodytes]
GI:4758332 RefSeq NP_075266.1 711 long-chain-fatty-acid--CoA ligase 4 isoform 2 [Homo sapiens]
GI:4758332 RefSeq XP_005262165.1 711 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X1 [Homo sapiens]
GI:4758332 RefSeq XP_005262166.1 711 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X2 [Homo sapiens]
GI:12669909 RefSeq XP_008973766.1 711 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X1 [Pan paniscus]
GI:12669909 RefSeq XP_008973767.1 711 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X1 [Pan paniscus]
GI:12669909 RefSeq XP_008973768.1 711 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X1 [Pan paniscus]
GI:4758332 SwissProt O60488.2 711 RecName: Full=Long-chain-fatty-acid--CoA ligase 4; AltName: Full=Long-chain acyl-CoA synthetase 4; Short=LACS 4 [Homo sapiens]