Gene/Proteome Database (LMPD)

LMPD ID
LMP002163
Gene ID
101476
Species
Mus musculus (Mouse)
Gene Name
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
Gene Symbol
Plekha1
Synonyms
AA960558; C920009D07Rik; TAPP1
Alternate Names
pleckstrin homology domain-containing family A member 1; TAPP-1; tandem PH domain-containing protein 1; PH domain-containing family A member 1
Chromosome
7
Map Location
7 F3|7

Proteins

pleckstrin homology domain-containing family A member 1
Refseq ID NP_598703
Protein GI 19527162
UniProt ID Q8BUL6
mRNA ID NM_133942
Length 356
RefSeq Status PROVISIONAL
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVPKQSDSQPASDSLSRQGDCGKKQVSYRTDIVGGVPIITPTQKEEVNECGESLDRNNLKRSQSHLPYFAPKPPSDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGRSSSSEHSGWPSEPKFTVRPAGAAATASHSPASRSHSLVSGCAMEKRGVYQSLAKVKPGNFKVQTVSPREPASKVTEQALLRPQSKNGPQGEDGEPVDLDDASLPVSDV

Gene Information

Entrez Gene ID
101476
Gene Name
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
Gene Symbol
Plekha1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0032587 IEA:Ensembl C ruffle membrane
GO:0043325 IEA:Ensembl F phosphatidylinositol-3,4-bisphosphate binding
GO:0050853 IEA:Ensembl P B cell receptor signaling pathway
GO:0033327 IMP:MGI P Leydig cell differentiation
GO:0008209 IMP:MGI P androgen metabolic process
GO:0070301 IEA:Ensembl P cellular response to hydrogen peroxide
GO:0045184 IEA:Ensembl P establishment of protein localization
GO:0008210 IGI:MGI P estrogen metabolic process
GO:0060325 IMP:MGI P face morphogenesis
GO:0008585 IGI:MGI P female gonad development
GO:0001553 IGI:MGI P luteinization
GO:0035264 IMP:MGI P multicellular organism growth
GO:0051898 IEA:Ensembl P negative regulation of protein kinase B signaling
GO:0060021 IMP:MGI P palate development
GO:0014065 IEA:Ensembl P phosphatidylinositol 3-kinase signaling
GO:0048008 IMP:MGI P platelet-derived growth factor receptor signaling pathway
GO:0009791 IMP:MGI P post-embryonic development
GO:0031529 IEA:Ensembl P ruffle organization
GO:0048705 IMP:MGI P skeletal system morphogenesis
GO:0007283 IMP:MGI P spermatogenesis

Domain Information

InterPro Annotations

Accession Description
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
Protein Entry
PKHA1_MOUSE
UniProt ID
Q8BUL6
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BUL6-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q8BUL6-2; Sequence=VSP_009764, VSP_009767; Note=No experimental confirmation available.;
Domain Binds to membranes enriched in PtdIns3,4P2 via the C- terminal PH domain.
Function Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). {ECO:0000250}.
Similarity Contains 2 PH domains. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2. {ECO:0000250}.
Subunit Interacts with MPDZ and PTPN13. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002163 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
19527162 RefSeq NP_598703 356 pleckstrin homology domain-containing family A member 1

Identical Sequences to LMP002163 proteins

Reference Database Accession Length Protein Name
GI:19527162 GenBank AAH20017.1 356 Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 [Mus musculus]
GI:19527162 GenBank EDL17687.1 356 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1, isoform CRA_d [Mus musculus]

Related Sequences to LMP002163 proteins

Reference Database Accession Length Protein Name
GI:19527162 GenBank EDL17684.1 404 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1, isoform CRA_a [Mus musculus]
GI:19527162 GenBank EDM17134.1 358 similar to Pleckstrin homology domain-containing protein family A member 1 (Tandem PH domain containing protein-1) (predicted), isoform CRA_b [Rattus norvegicus]
GI:19527162 GenBank ERE77381.1 356 pleckstrin homology domain-containing family A member 1 [Cricetulus griseus]
GI:19527162 RefSeq XP_006507208.1 404 PREDICTED: pleckstrin homology domain-containing family A member 1 isoform X6 [Mus musculus]
GI:19527162 RefSeq XP_006977036.1 404 PREDICTED: pleckstrin homology domain-containing family A member 1 isoform X3 [Peromyscus maniculatus bairdii]
GI:19527162 RefSeq XP_008825489.1 356 PREDICTED: pleckstrin homology domain-containing family A member 1 isoform X3 [Nannospalax galili]