Gene/Proteome Database (LMPD)

LMPD ID
LMP002167
Gene ID
11689
Species
Mus musculus (Mouse)
Gene Name
arachidonate 5-lipoxygenase
Gene Symbol
Alox5
Synonyms
5-LO; 5-LOX; 5LO; 5LX; AI850497; F730011J02
Alternate Names
arachidonate 5-lipoxygenase; 5-lipoxygenase
Chromosome
6
Map Location
6 F1|6 53.79 cM
EC Number
1.13.11.34

Proteins

arachidonate 5-lipoxygenase
Refseq ID NP_033792
Protein GI 62526037
UniProt ID P48999
mRNA ID NM_009662
Length 674
RefSeq Status VALIDATED
MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGAVDSYDVTVDEELGEIYLVKIEKRKYWLHDDWYLKYITLKTPHGDYIEFPCYRWITGEGEIVLRDGRAKLARDDQIHILKQHRRKELEARQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGCNPVLIKRCTALPPKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPCTHQFLAAPICLLYKNLANKIVPIAIQLNQTPGESNPIFLPTDSKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLICEYGLFDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDSTEDIPFYFYRDDGLLVWEAIQSFTMEVVSIYYENDQVVEEDQELQDFVKDVYVYGMRGKKASGFPKSIKSREKLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYYYLSPDRIPNSVAI

Gene Information

Entrez Gene ID
11689
Gene Name
arachidonate 5-lipoxygenase
Gene Symbol
Alox5
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:MGI C cytoplasm
GO:0005829 ISS:UniProtKB C cytosol
GO:0005615 IEA:Ensembl C extracellular space
GO:0005641 ISS:UniProtKB C nuclear envelope lumen
GO:0016363 IEA:Ensembl C nuclear matrix
GO:0031965 ISS:UniProtKB C nuclear membrane
GO:0005634 IDA:MGI C nucleus
GO:0004051 IEA:UniProtKB-EC F arachidonate 5-lipoxygenase activity
GO:0005506 ISS:UniProtKB F iron ion binding
GO:0006954 IMP:MGI P inflammatory response
GO:0019370 IDA:MGI P leukotriene biosynthetic process
GO:0006691 IMP:MGI P leukotriene metabolic process
GO:0002540 IMP:MGI P leukotriene production involved in inflammatory response

KEGG Pathway Links

KEGG Pathway ID Description
mmu04913 Ovarian steroidogenesis
mmu04726 Serotonergic synapse

Domain Information

InterPro Annotations

Accession Description
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR000907 Lipoxygenase
IPR013819 Lipoxygenase, C-terminal
IPR020834 Lipoxygenase, conserved site
IPR020833 Lipoxygenase, iron binding site
IPR001885 Lipoxygenase, mammalian
IPR001024 PLAT/LH2 domain

UniProt Annotations

Entry Information

Gene Name
arachidonate 5-lipoxygenase
Protein Entry
LOX5_MOUSE
UniProt ID
P48999
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Arachidonate + O(2) = leukotriene A(4) + H(2)O.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 2 calcium ions per subunit. {ECO:0000250};
Cofactor Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000255|PROSITE-ProRule:PRU00726}; Note=Binds 1 Fe cation per subunit. {ECO:0000255|PROSITE- ProRule:PRU00726};
Function Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. {ECO:0000269|PubMed:7629107}.
Pathway Lipid metabolism; leukotriene A4 biosynthesis.
Ptm Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-524 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus (By similarity). {ECO:0000250}.
Similarity Belongs to the lipoxygenase family. {ECO:0000305}.
Similarity Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Similarity Contains 1 lipoxygenase domain. {ECO:0000255|PROSITE- ProRule:PRU00726}.
Subcellular Location Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00726, ECO:0000269|PubMed:7629107}. Nucleus matrix {ECO:0000269|PubMed:7629107}. Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association (By similarity). {ECO:0000250}.
Subunit Interacts with ALOX5AP and LTC4S. Interacts with COTL1, the interaction is required for stability and efficient catalytic activity (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002167 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
62526037 RefSeq NP_033792 674 arachidonate 5-lipoxygenase

Identical Sequences to LMP002167 proteins

Reference Database Accession Length Protein Name
GI:62526037 DBBJ BAE42439.1 674 unnamed protein product [Mus musculus]
GI:62526037 DBBJ BAE23373.1 674 unnamed protein product [Mus musculus]
GI:62526037 GenBank AAI39103.1 674 Arachidonate 5-lipoxygenase [Mus musculus]
GI:62526037 GenBank AAI41214.1 674 Arachidonate 5-lipoxygenase [Mus musculus]
GI:62526037 SwissProt P48999.3 674 RecName: Full=Arachidonate 5-lipoxygenase; Short=5-LO; Short=5-lipoxygenase [Mus musculus]

Related Sequences to LMP002167 proteins

Reference Database Accession Length Protein Name
GI:62526037 DBBJ BAE42089.1 674 unnamed protein product [Mus musculus]
GI:62526037 DBBJ BAE42301.1 674 unnamed protein product [Mus musculus]
GI:62526037 GenBank AAC37673.1 674 arachidonate 5-lipoxygenase [Mus musculus]
GI:62526037 GenBank EDK99559.1 674 arachidonate 5-lipoxygenase, isoform CRA_a [Mus musculus]
GI:62526037 RefSeq XP_005365122.1 674 PREDICTED: arachidonate 5-lipoxygenase isoform X1 [Microtus ochrogaster]
GI:62526037 RefSeq XP_006237202.1 674 PREDICTED: arachidonate 5-lipoxygenase isoform X1 [Rattus norvegicus]