Gene/Proteome Database (LMPD)
LMPD ID
LMP002171
Gene ID
Species
Mus musculus (Mouse)
Gene Name
serine palmitoyltransferase, long chain base subunit 1
Gene Symbol
Synonyms
AW552086; C77762; E030036H05; Lcb1
Alternate Names
serine palmitoyltransferase 1; SPT1; LCB 1; SPT 1; serine-palmitoyl-CoA transferase 1; long chain base biosynthesis protein 1
Chromosome
13
Map Location
13 B1|13
EC Number
2.3.1.50
Proteins
| serine palmitoyltransferase 1 | |
|---|---|
| Refseq ID | NP_033295 |
| Protein GI | 29244577 |
| UniProt ID | O35704 |
| mRNA ID | NM_009269 |
| Length | 473 |
| RefSeq Status | PROVISIONAL |
| MATVAEQWVLVEMVQALYEAPAYHLILEGILILWIIRLVFSKTYKLQERSDLTAKEKEELIEEWQPEPLVPPVSKNHPALNYNIVSGPPTHNIVVNGKECVNFASFNFLGLLANPRVKATAFSSLKKYGVGTCGPRGFYGTFDVHLDLEERLAKFMKTEEAIIYSYGFSTIASAIPAYSKRGDIIFVDSAACFAIQKGLQASRSDIKLFKHNDVADLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGISIDDIDLISANMENALASVGGFCCGRSFVVDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPDIFAVLKKKCQNIHKSLQGVSGLKVVGESLSPALHLQLEESTGSREKDVKLLQAIVDQCMDKGIALTQARYLDKEEKCLPPPSIRVVVTVEQTEEELQRAASTIREAAQAVLL | |
Gene Information
Entrez Gene ID
Gene Name
serine palmitoyltransferase, long chain base subunit 1
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0035339 | ISS:UniProtKB | C | SPOTS complex |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0017059 | ISA:MGI | C | serine C-palmitoyltransferase complex |
| GO:0030170 | IEA:InterPro | F | pyridoxal phosphate binding |
| GO:0016746 | IEA:UniProtKB-KW | F | transferase activity, transferring acyl groups |
| GO:0046513 | IMP:MGI | P | ceramide biosynthetic process |
| GO:0046511 | IMP:MGI | P | sphinganine biosynthetic process |
| GO:0006686 | IMP:MGI | P | sphingomyelin biosynthetic process |
| GO:0046512 | IMP:MGI | P | sphingosine biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| mmu00600 | Sphingolipid metabolism |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY3DJ-12 | ceramide biosynthesis |
Domain Information
UniProt Annotations
Entry Information
Gene Name
serine palmitoyltransferase, long chain base subunit 1
Protein Entry
SPTC1_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D- sphinganine + CO(2). |
| Cofactor | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000250}; |
| Function | Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates. The SPTLC1-SPTLC2-SPTSSB complex displays a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme has the ability to use a broader range of acyl-CoAs (By similarity). {ECO:0000250}. |
| Pathway | Lipid metabolism; sphingolipid metabolism. |
| Ptm | Phosphorylation at Tyr-164 inhibits activity and promotes cell survival. {ECO:0000250}. |
| Similarity | Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:1317856}; Single-pass membrane protein {ECO:0000269|PubMed:1317856}. |
| Subunit | Heterodimer with SPTLC2 or SPTLC3. Component of the serine palmitoyltransferase (SPT) complex, composed of SPTLC1, either SPTLC2 or SPTLC3, and either SPTSSA or SPTSSB. Interacts with SPTSSA and SPTSSB; the interaction is direct. Interacts with ORMDL3 (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in a variety of tissues. Highest expression in brain, kidney and liver. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002171 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 29244577 | RefSeq | NP_033295 | 473 | serine palmitoyltransferase 1 |
Identical Sequences to LMP002171 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:29244577 | DBBJ | BAC35310.1 | 473 | unnamed protein product [Mus musculus] |
| GI:29244577 | DBBJ | BAC37690.1 | 473 | unnamed protein product [Mus musculus] |
| GI:29244577 | DBBJ | BAC39172.1 | 473 | unnamed protein product [Mus musculus] |
| GI:29244577 | DBBJ | BAC39185.1 | 473 | unnamed protein product [Mus musculus] |
| GI:29244577 | GenBank | AAH46323.1 | 473 | Serine palmitoyltransferase, long chain base subunit 1 [Mus musculus] |
| GI:29244577 | SwissProt | O35704.2 | 473 | RecName: Full=Serine palmitoyltransferase 1; AltName: Full=Long chain base biosynthesis protein 1; Short=LCB 1; AltName: Full=Serine-palmitoyl-CoA transferase 1; Short=SPT 1; Short=SPT1 [Mus musculus] |
Related Sequences to LMP002171 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:29244577 | DBBJ | BAC40709.1 | 473 | unnamed protein product [Mus musculus] |
| GI:29244577 | DBBJ | BAE36210.1 | 473 | unnamed protein product [Mus musculus] |
| GI:29244577 | DBBJ | BAE20444.1 | 473 | unnamed protein product [Mus musculus] |
| GI:29244577 | EMBL | CAA64897.1 | 473 | serine C-palmitoyltransferase [Mus musculus] |
| GI:29244577 | GenBank | AAC02264.1 | 473 | serine palmitoyltransferase LCB1 subunit [Mus musculus] |
| GI:29244577 | GenBank | EDL41121.1 | 476 | serine palmitoyltransferase, long chain base subunit 1, partial [Mus musculus] |