Gene/Proteome Database (LMPD)
LMPD ID
LMP002186
Gene ID
Species
Homo sapiens (Human)
Gene Name
UDP glucuronosyltransferase 1 family, polypeptide A3
Gene Symbol
Synonyms
UDPGT; UDPGT 1-3; UGT-1C; UGT1-03; UGT1.3; UGT1C
Alternate Names
UDP-glucuronosyltransferase 1-3; UGT1*3; UDP-glucuronosyltransferase 1-C; UDP-glucuronosyltransferase 1A3; UDP glycosyltransferase 1 family, polypeptide A3
Chromosome
2
Map Location
2q37
EC Number
2.4.1.17
Summary
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| UDP-glucuronosyltransferase 1-3 precursor | |
|---|---|
| Refseq ID | NP_061966 |
| Protein GI | 13487900 |
| UniProt ID | P35503 |
| mRNA ID | NM_019093 |
| Length | 534 |
| RefSeq Status | REVIEWED |
| MATGLQVPLPWLATGLLLLLSVQPWAESGKVLVVPIDGSHWLSMREVLRELHARGHQAVVLTPEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNMSLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPCDLDFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASELFQREVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH | |
| sig_peptide: 1..28 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3006 peptide sequence: MATGLQVPLPWLATGLLLLLSVQPWAES mat_peptide: 29..534 product: UDP-glucuronosyltransferase 1-3 calculated_mol_wt: 57351 peptide sequence: GKVLVVPIDGSHWLSMREVLRELHARGHQAVVLTPEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNMSLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPCDLDFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASELFQREVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH | |
Gene Information
Entrez Gene ID
Gene Name
UDP glucuronosyltransferase 1 family, polypeptide A3
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IDA:UniProt | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0008194 | TAS:ProtInc | F | UDP-glycosyltransferase activity |
| GO:0019899 | IDA:BHF-UCL | F | enzyme binding |
| GO:0015020 | IDA:BHF-UCL | F | glucuronosyltransferase activity |
| GO:0046982 | IDA:UniProt | F | protein heterodimerization activity |
| GO:0042803 | IDA:UniProt | F | protein homodimerization activity |
| GO:0001972 | IDA:BHF-UCL | F | retinoic acid binding |
| GO:0052695 | IDA:UniProt | P | cellular glucuronidation |
| GO:0052696 | IDA:BHF-UCL | P | flavonoid glucuronidation |
| GO:0008152 | TAS:ProtInc | P | metabolic process |
| GO:0042573 | IC:BHF-UCL | P | retinoic acid metabolic process |
| GO:0052697 | IDA:BHF-UCL | P | xenobiotic glucuronidation |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR002213 | UDP-glucuronosyl/UDP-glucosyltransferase |
UniProt Annotations
Entry Information
Gene Name
UDP glucuronosyltransferase 1 family, polypeptide A3
Protein Entry
UD13_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=i1; IsoId=P35503-1; Sequence=Displayed; Name=2; Synonyms=i2, UGT1A3s; IsoId=P35503-3; Sequence=VSP_053959; |
| Catalytic Activity | UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. |
| Function | UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. |
| Miscellaneous | The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity. |
| Similarity | Belongs to the UDP-glycosyltransferase family. |
| Subcellular Location | Microsome. Endoplasmic reticulum membrane {ECO |
| Subunit | Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10. |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in liver, kidney, colon and small intestine. Isoform 1 but not isoform 2 is expressed in esophagus. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002186 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 13487900 | RefSeq | NP_061966 | 534 | UDP-glucuronosyltransferase 1-3 precursor |
Identical Sequences to LMP002186 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:13487900 | GenBank | EAW71060.1 | 534 | hCG2039726, isoform CRA_h [Homo sapiens] |
| GI:13487900 | GenBank | AAI66641.1 | 534 | UDP glucuronosyltransferase 1 family, polypeptide A3 [synthetic construct] |
| GI:13487900 | GenBank | ADA53242.1 | 534 | Sequence 1072 from patent US 7625699 |
| GI:13487900 | GenBank | ADT46661.1 | 534 | Sequence 322 from patent US 7842466 |
| GI:13487900 | GenBank | ADT46675.1 | 534 | Sequence 336 from patent US 7842466 |
| GI:13487900 | GenBank | AHE01393.1 | 534 | Sequence 56309 from patent US 8586006 |
Related Sequences to LMP002186 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:13487900 | EMBL | CAH91064.1 | 534 | hypothetical protein [Pongo abelii] |
| GI:13487900 | RefSeq | XP_001151100.1 | 534 | PREDICTED: UDP-glucuronosyltransferase 1-3 isoform X2 [Pan troglodytes] |
| GI:13487900 | RefSeq | NP_001125615.1 | 534 | UDP-glucuronosyltransferase 1-3 precursor [Pongo abelii] |
| GI:13487900 | RefSeq | XP_003278593.1 | 534 | PREDICTED: UDP-glucuronosyltransferase 1-6-like isoform 6 [Nomascus leucogenys] |
| GI:13487900 | RefSeq | XP_008963952.1 | 534 | PREDICTED: UDP-glucuronosyltransferase 1-3 isoform X1 [Pan paniscus] |
| GI:13487900 | RefSeq | XP_009236524.1 | 534 | PREDICTED: UDP-glucuronosyltransferase 1-3 isoform X2 [Pongo abelii] |