Gene/Proteome Database (LMPD)
LMPD ID
LMP002207
Gene ID
Species
Homo sapiens (Human)
Gene Name
fatty acid amide hydrolase
Gene Symbol
Synonyms
FAAH-1; PSAB
Alternate Names
fatty-acid amide hydrolase 1; oleamide hydrolase 1; anandamide amidohydrolase 1
Chromosome
1
Map Location
1p35-p34
EC Number
3.5.1.99
Summary
This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| fatty-acid amide hydrolase 1 | |
|---|---|
| Refseq ID | NP_001432 |
| Protein GI | 166795287 |
| UniProt ID | O00519 |
| mRNA ID | NM_001441 |
| Length | 579 |
| RefSeq Status | REVIEWED |
| MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IEA:UniProtKB-KW | C | cytoplasm |
| GO:0005856 | IEA:UniProtKB-KW | C | cytoskeleton |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0031090 | ISS:UniProtKB | C | organelle membrane |
| GO:0047372 | IEA:Ensembl | F | acylglycerol lipase activity |
| GO:0016884 | IEA:InterPro | F | carbon-nitrogen ligase activity, with glutamine as amido-N-donor |
| GO:0017064 | IDA:UniProtKB | F | fatty acid amide hydrolase activity |
| GO:0009062 | IDA:UniProtKB | P | fatty acid catabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa04723 | Retrograde endocannabinoid signaling |
| ko04723 | Retrograde endocannabinoid signaling |
BIOCYC Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Anandamide + H(2)O = arachidonic acid + ethanolamine. |
| Catalytic Activity | Oleamide + H(2)O = oleic acid + NH(3). |
| Enzyme Regulation | Inhibited by O-aryl carbamates and alpha-keto heterocytes. |
| Function | Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. |
| Polymorphism | Genetic variations in FAAH can be associated with susceptibility to polysubstance abuse [MIM |
| Similarity | Belongs to the amidase family. |
| Subcellular Location | Endomembrane system ; Single-pass membrane protein . Cytoplasm, cytoskeleton . Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network. |
| Subunit | Homodimer. |
| Tissue Specificity | Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate. |
| Web Resource | Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/faah/"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP002207 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 166795287 | RefSeq | NP_001432 | 579 | fatty-acid amide hydrolase 1 |
Identical Sequences to LMP002207 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:166795287 | GenBank | AAI11942.1 | 579 | Fatty acid amide hydrolase [Homo sapiens] |
| GI:166795287 | GenBank | AAI10405.1 | 579 | Fatty acid amide hydrolase [Homo sapiens] |
| GI:166795287 | GenBank | AEH98555.1 | 579 | Sequence 1 from patent US 7947663 |
| GI:166795287 | GenBank | AGA52809.1 | 579 | Sequence 1 from patent US 8329675 |
| GI:166795287 | GenBank | AGD76739.1 | 579 | Sequence 1 from patent US 8349814 |
| GI:166795287 | GenBank | AHH78030.1 | 579 | Sequence 1 from patent US 8629125 |
Related Sequences to LMP002207 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:166795287 | GenBank | AAE78251.1 | 590 | Sequence 43 from patent US 6271015 |
| GI:166795287 | GenBank | ACC29985.1 | 590 | Sequence 43 from patent US 7348173 |
| GI:166795287 | GenBank | AED39481.1 | 579 | Sequence 1874 from patent US 7883858 |
| GI:166795287 | GenBank | AED78183.1 | 579 | Sequence 2 from patent US 7915261 |
| GI:166795287 | GenBank | AED82872.1 | 579 | Sequence 2 from patent US 7919494 |
| GI:166795287 | GenBank | AED82876.1 | 579 | Sequence 2 from patent US 7919495 |