Gene/Proteome Database (LMPD)
LMPD ID
LMP002212
Gene ID
Species
Homo sapiens (Human)
Gene Name
acyl-CoA thioesterase 11
Gene Symbol
Synonyms
BFIT; STARD14; THEA; THEM1
Alternate Names
acyl-coenzyme A thioesterase 11; START domain containing 14; acyl-CoA thioester hydrolase 11; adipose-associated thioesterase; brown fat-inducible thioesterase; thioesterase, adipose associated; thioesterase superfamily member 1; StAR-related lipid transfer (START) domain containing 14
Chromosome
1
Map Location
1p32.3
EC Number
3.1.2.-
Summary
This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
Orthologs
Proteins
| acyl-coenzyme A thioesterase 11 isoform 1 | |
|---|---|
| Refseq ID | NP_056362 |
| Protein GI | 22165355 |
| UniProt ID | Q8WXI4 |
| mRNA ID | NM_015547 |
| Length | 607 |
| RefSeq Status | REVIEWED |
| MIQNVGNHLRRGLASVFSNRTSRKSALRAGNDSAMADGEGYRNPTEVQMSQLVLPCHTNQRGELSVGQLLKWIDTTACLSAERHAGCPCVTASMDDIYFEHTISVGQVVNIKAKVNRAFNSSMEVGIQVASEDLCSEKQWNVCKALATFVARREITKVKLKQITPRTEEEKMEHSVAAERRRMRLVYADTIKDLLANCAIQGDLESRDCSRMVPAEKTRVESVELVLPPHANHQGNTFGGQIMAWMENVATIAASRLCRAHPTLKAIEMFHFRGPSQVGDRLVLKAIVNNAFKHSMEVGVCVEAYRQEAETHRRHINSAFMTFVVLDADDQPQLLPWIRPQPGDGERRYREASARKKIRLDRKYIVSCKQTEVPLSVPWDPSNQVYLSYNNVSSLKMLVAKDNWVLSSEISQVRLYTLEDDKFLSFHMEMVVHVDAAQAFLLLSDLRQRPEWDKHYRSVELVQQVDEDDAIYHVTSPALGGHTKPQDFVILASRRKPCDNGDPYVIALRSVTLPTHRETPEYRRGETLCSGFCLWREGDQLTKCCWVRVSLTELVSASGFYSWGLESRSKGRRSDGWNGKLAGGHLSTLKAIPVAKINSRFGYLQDT | |
| acyl-coenzyme A thioesterase 11 isoform 2 | |
|---|---|
| Refseq ID | NP_671517 |
| Protein GI | 22165400 |
| UniProt ID | Q8WXI4 |
| mRNA ID | NM_147161 |
| Length | 594 |
| RefSeq Status | REVIEWED |
| MIQNVGNHLRRGLASVFSNRTSRKSALRAGNDSAMADGEGYRNPTEVQMSQLVLPCHTNQRGELSVGQLLKWIDTTACLSAERHAGCPCVTASMDDIYFEHTISVGQVVNIKAKVNRAFNSSMEVGIQVASEDLCSEKQWNVCKALATFVARREITKVKLKQITPRTEEEKMEHSVAAERRRMRLVYADTIKDLLANCAIQGDLESRDCSRMVPAEKTRVESVELVLPPHANHQGNTFGGQIMAWMENVATIAASRLCRAHPTLKAIEMFHFRGPSQVGDRLVLKAIVNNAFKHSMEVGVCVEAYRQEAETHRRHINSAFMTFVVLDADDQPQLLPWIRPQPGDGERRYREASARKKIRLDRKYIVSCKQTEVPLSVPWDPSNQVYLSYNNVSSLKMLVAKDNWVLSSEISQVRLYTLEDDKFLSFHMEMVVHVDAAQAFLLLSDLRQRPEWDKHYRSVELVQQVDEDDAIYHVTSPALGGHTKPQDFVILASRRKPCDNGDPYVIALRSVTLPTHRETPEYRRGETLCSGFCLWREGDQLTKVSYYNQATPGVLNYVTTNVAGLSSEFYTTFKACEQFLLDNRNDLAPSLQTL | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IC:UniProtKB | C | cytoplasm |
| GO:0070062 | IDA:UniProt | C | extracellular vesicular exosome |
| GO:0047617 | TAS:UniProtKB | F | acyl-CoA hydrolase activity |
| GO:0052689 | IEA:UniProtKB-KW | F | carboxylic ester hydrolase activity |
| GO:0008289 | IEA:InterPro | F | lipid binding |
| GO:0006631 | NAS:UniProtKB | P | fatty acid metabolic process |
| GO:0035556 | NAS:UniProtKB | P | intracellular signal transduction |
| GO:0009409 | ISS:BHF-UCL | P | response to cold |
| GO:0009266 | ISS:UniProtKB | P | response to temperature stimulus |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=BFIT1; IsoId=Q8WXI4-1; Sequence=Displayed; Name=2; Synonyms=BFIT2; IsoId=Q8WXI4-2; Sequence=VSP_000160; |
| Function | Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. |
| Induction | By cold exposure and repressed by heat exposure. |
| Sequence Caution | Sequence=BAA31682.1; Type=Erroneous initiation; Evidence= ; |
| Similarity | Contains 1 START domain. {ECO |
| Similarity | Contains 2 acyl coenzyme A hydrolase domains. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Isoform 1 is predominantly expressed in skeletal muscle, liver, testis, stomach, spleen, lung and brain. Isoform 2 is predominantly expressed in kidney, uterus, hibernoma and white adipose tissue. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002212 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 22165355 | RefSeq | NP_056362 | 607 | acyl-coenzyme A thioesterase 11 isoform 1 |
| 22165400 | RefSeq | NP_671517 | 594 | acyl-coenzyme A thioesterase 11 isoform 2 |
Identical Sequences to LMP002212 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:22165400 | EMBL | CAE91952.1 | 594 | unnamed protein product [Homo sapiens] |
| GI:22165355 | GenBank | AAL40937.1 | 607 | brown fat inducible thioesterase 1 [Homo sapiens] |
| GI:22165400 | GenBank | AAL40938.1 | 594 | brown fat inducible thioesterase 2 [Homo sapiens] |
| GI:22165400 | GenBank | AAH93844.1 | 594 | Thioesterase, adipose associated, isoform BFIT2 [Homo sapiens] |
| GI:22165400 | GenBank | AAH93846.1 | 594 | Thioesterase, adipose associated, isoform BFIT2 [Homo sapiens] |
| GI:22165355 | GenBank | EAX06682.1 | 607 | acyl-CoA thioesterase 11, isoform CRA_a, partial [Homo sapiens] |
| GI:22165400 | GenBank | EAX06683.1 | 594 | acyl-CoA thioesterase 11, isoform CRA_b [Homo sapiens] |
| GI:22165400 | GenBank | EAX06684.1 | 594 | acyl-CoA thioesterase 11, isoform CRA_b [Homo sapiens] |
| GI:22165355 | SwissProt | Q8WXI4.1 | 607 | RecName: Full=Acyl-coenzyme A thioesterase 11; Short=Acyl-CoA thioesterase 11; AltName: Full=Acyl-CoA thioester hydrolase 11; AltName: Full=Adipose-associated thioesterase; AltName: Full=Brown fat-inducible thioesterase; Short=BFIT [Homo sapiens] |
Related Sequences to LMP002212 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:22165355 | DBBJ | BAA31682.1 | 630 | KIAA0707 protein, partial [Homo sapiens] |
| GI:22165355 | DBBJ | BAB14734.1 | 594 | unnamed protein product [Homo sapiens] |
| GI:22165400 | DBBJ | BAD97290.1 | 594 | thioesterase, adipose associated isoform BFIT2 variant, partial [Homo sapiens] |
| GI:22165355 | EMBL | CAE91952.1 | 594 | unnamed protein product [Homo sapiens] |
| GI:22165400 | EMBL | CAH89858.1 | 594 | hypothetical protein [Pongo abelii] |
| GI:22165355 | GenBank | EAX06683.1 | 594 | acyl-CoA thioesterase 11, isoform CRA_b [Homo sapiens] |
| GI:22165355 | GenBank | EAX06684.1 | 594 | acyl-CoA thioesterase 11, isoform CRA_b [Homo sapiens] |
| GI:22165400 | GenBank | JAA35631.1 | 594 | acyl-CoA thioesterase 11 [Pan troglodytes] |
| GI:22165355 | RefSeq | NP_671517.1 | 594 | acyl-coenzyme A thioesterase 11 isoform 2 [Homo sapiens] |
| GI:22165400 | RefSeq | XP_001152786.1 | 594 | PREDICTED: acyl-coenzyme A thioesterase 11 isoform X2 [Pan troglodytes] |
| GI:22165400 | RefSeq | NP_001127204.1 | 594 | acyl-coenzyme A thioesterase 11 [Pongo abelii] |
| GI:22165400 | RefSeq | XP_003815040.1 | 594 | PREDICTED: acyl-coenzyme A thioesterase 11 isoform X2 [Pan paniscus] |