Gene/Proteome Database (LMPD)

LMPD ID
LMP002215
Gene ID
3929
Species
Homo sapiens (Human)
Gene Name
lipopolysaccharide binding protein
Gene Symbol
LBP
Synonyms
BPIFD2
Alternate Names
lipopolysaccharide-binding protein; LPS-binding protein; BPI fold containing family D, member 2
Chromosome
20
Map Location
20q11.23
Summary
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]
Orthologs
View orthologs and multiple alignments for LBP

Proteins

lipopolysaccharide-binding protein precursor
Refseq ID NP_004130
Protein GI 31652249
UniProt ID P18428
mRNA ID NM_004139
Length 481
RefSeq Status REVIEWED
MGALARALPSILLALLLTSTPEALGANPGLVARITDKGLQYAAQEGLLALQSELLRITLPDFTGDLRIPHVGRGRYEFHSLNIHSCELLHSALRPVPGQGLSLSISDSSIRVQGRWKVRKSFFKLQGSFDVSVKGISISVNLLLGSESSGRPTVTASSCSSDIADVEVDMSGDLGWLLNLFHNQIESKFQKVLESRICEMIQKSVSSDLQPYLQTLPVTTEIDSFADIDYSLVEAPRATAQMLEVMFKGEIFHRNHRSPVTLLAAVMSLPEEHNKMVYFAISDYVFNTASLVYHEEGYLNFSITDDMIPPDSNIRLTTKSFRPFVPRLARLYPNMNLELQGSVPSAPLLNFSPGNLSVDPYMEIDAFVLLPSSSKEPVFRLSVATNVSATLTFNTSKITGFLKPGKVKVELKESKVGLFNAELLEALLNYYILNTFYPKFNDKLAEGFPLPLLKRVQLYDLGLQIHKDFLFLGANVQYMRV
sig_peptide: 1..25 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2493 peptide sequence: MGALARALPSILLALLLTSTPEALG mat_peptide: 26..481 product: lipopolysaccharide-binding protein calculated_mol_wt: 50909 peptide sequence: ANPGLVARITDKGLQYAAQEGLLALQSELLRITLPDFTGDLRIPHVGRGRYEFHSLNIHSCELLHSALRPVPGQGLSLSISDSSIRVQGRWKVRKSFFKLQGSFDVSVKGISISVNLLLGSESSGRPTVTASSCSSDIADVEVDMSGDLGWLLNLFHNQIESKFQKVLESRICEMIQKSVSSDLQPYLQTLPVTTEIDSFADIDYSLVEAPRATAQMLEVMFKGEIFHRNHRSPVTLLAAVMSLPEEHNKMVYFAISDYVFNTASLVYHEEGYLNFSITDDMIPPDSNIRLTTKSFRPFVPRLARLYPNMNLELQGSVPSAPLLNFSPGNLSVDPYMEIDAFVLLPSSSKEPVFRLSVATNVSATLTFNTSKITGFLKPGKVKVELKESKVGLFNAELLEALLNYYILNTFYPKFNDKLAEGFPLPLLKRVQLYDLGLQIHKDFLFLGANVQYMRV

Gene Information

Entrez Gene ID
3929
Gene Name
lipopolysaccharide binding protein
Gene Symbol
LBP
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009986 IDA:BHF-UCL C cell surface
GO:0005576 TAS:Reactome C extracellular region
GO:0005615 IDA:BHF-UCL C extracellular space
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0001530 ISS:BHF-UCL F lipopolysaccharide binding
GO:0070891 IDA:MGI F lipoteichoic acid binding
GO:0005102 ISS:BHF-UCL F receptor binding
GO:0006953 IEP:BHF-UCL P acute-phase response
GO:0006968 ISS:BHF-UCL P cellular defense response
GO:0071222 IDA:MGI P cellular response to lipopolysaccharide
GO:0071223 IDA:MGI P cellular response to lipoteichoic acid
GO:0050829 IDA:BHF-UCL P defense response to Gram-negative bacterium
GO:0050830 IDA:BHF-UCL P defense response to Gram-positive bacterium
GO:0032490 IDA:BHF-UCL P detection of molecule of bacterial origin
GO:0045087 ISS:BHF-UCL P innate immune response
GO:0002232 IEA:Ensembl P leukocyte chemotaxis involved in inflammatory response
GO:0015920 IDA:BHF-UCL P lipopolysaccharide transport
GO:0031663 IDA:BHF-UCL P lipopolysaccharide-mediated signaling pathway
GO:0002281 ISS:BHF-UCL P macrophage activation involved in immune response
GO:0044130 IEA:Ensembl P negative regulation of growth of symbiont in host
GO:0032720 IDA:BHF-UCL P negative regulation of tumor necrosis factor production
GO:0008228 ISS:BHF-UCL P opsonization
GO:0032722 IEA:Ensembl P positive regulation of chemokine production
GO:0032755 IDA:BHF-UCL P positive regulation of interleukin-6 production
GO:0032757 IDA:BHF-UCL P positive regulation of interleukin-8 production
GO:0043032 IDA:BHF-UCL P positive regulation of macrophage activation
GO:0090023 IEA:Ensembl P positive regulation of neutrophil chemotaxis
GO:0060265 ISS:BHF-UCL P positive regulation of respiratory burst involved in inflammatory response
GO:0034145 IDA:BHF-UCL P positive regulation of toll-like receptor 4 signaling pathway
GO:0042535 IEA:Ensembl P positive regulation of tumor necrosis factor biosynthetic process
GO:0032760 IDA:BHF-UCL P positive regulation of tumor necrosis factor production
GO:0032496 IDA:BHF-UCL P response to lipopolysaccharide
GO:0034142 TAS:Reactome P toll-like receptor 4 signaling pathway
GO:0002224 TAS:Reactome P toll-like receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
hsa04064 NF-kappa B signaling pathway
hsa05132 Salmonella infection
hsa04620 Toll-like receptor signaling pathway
hsa05152 Tuberculosis

Domain Information

InterPro Annotations

Accession Description
IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain
IPR001124 Lipid-binding serum glycoprotein, C-terminal
IPR017942 Lipid-binding serum glycoprotein, N-terminal
IPR017954 Lipid-binding serum glycoprotein, conserved site

UniProt Annotations

Entry Information

Gene Name
lipopolysaccharide binding protein
Protein Entry
LBP_HUMAN
UniProt ID
P18428
Species
Human

Comments

Comment Type Description
Function Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
Interaction Q13162:PRDX4; NbExp=4; IntAct=EBI-3927059, EBI-2211957;
Similarity Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Subcellular Location Secreted .
Subunit When bound to LPS, interacts (via C-terminus) with soluble CD14.
Tissue Specificity Detected in blood serum (at protein level).

Identical and Related Proteins

Unique RefSeq proteins for LMP002215 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31652249 RefSeq NP_004130 481 lipopolysaccharide-binding protein precursor

Identical Sequences to LMP002215 proteins

Reference Database Accession Length Protein Name
GI:31652249 DBBJ BAG36385.1 481 unnamed protein product [Homo sapiens]
GI:31652249 GenBank EAW76034.1 481 lipopolysaccharide binding protein, isoform CRA_b [Homo sapiens]
GI:31652249 GenBank ACP57433.1 481 Sequence 1562 from patent US 7482117
GI:31652249 GenBank ADS31030.1 481 Sequence 1562 from patent US 7781168
GI:31652249 GenBank AFO05843.1 481 Sequence 481 from patent US 8216786
GI:31652249 GenBank AHE01253.1 481 Sequence 56169 from patent US 8586006

Related Sequences to LMP002215 proteins

Reference Database Accession Length Protein Name
GI:31652249 GenBank AAA95647.1 481 Sequence 2 from patent US 5484705
GI:31652249 GenBank AAB13522.1 481 Sequence 98 from patent US 5523288
GI:31652249 GenBank AAB43485.1 481 Sequence 98 from patent US 5578572
GI:31652249 GenBank AAE55012.1 481 Sequence 98 from patent US 6153730
GI:31652249 GenBank AAE79037.1 481 Sequence 2 from patent US 6274328
GI:31652249 GenBank ACM84788.1 486 Sequence 10286 from patent US 6812339