Gene/Proteome Database (LMPD)
LMPD ID
LMP002218
Gene ID
Species
Mus musculus (Mouse)
Gene Name
acyl-Coenzyme A dehydrogenase family, member 8
Gene Symbol
Synonyms
2310016C19Rik; AI786953
Alternate Names
isobutyryl-CoA dehydrogenase, mitochondrial; ACAD-8; acyl-CoA dehydrogenase family member 8
Chromosome
9
Map Location
9 A4|9
EC Number
1.3.99.-
Proteins
| isobutyryl-CoA dehydrogenase, mitochondrial precursor | |
|---|---|
| Refseq ID | NP_080138 |
| Protein GI | 118403322 |
| UniProt ID | Q9D7B6 |
| mRNA ID | NM_025862 |
| Length | 413 |
| RefSeq Status | VALIDATED |
| MAMLRSGYRRFGCLRAALKSLAQTHHRSITFCIDPSLGLNEEQKGFQKVAFDFAAREMAPNMAEWDQKELFPVDVMRKAAQLGFGGVYVRTDVGGSGLSRLDTSVIFEALATGCTSTTAYISIHNMCAWMIDSFGNEEQRHKFCPPLCTMEKFASYCLTEPGSGSDAASLLTSAKQQGDHYILNGSKAFISGGGESDIYVVMCRTGESGAKGISCIVVEKGTPGLSFGKKEKKVGWNSQPTRAVIFEDCAVPVANRIGTEGQGFLIAMKGLNGGRINVASCSLGAAHASVILTQEHLKVRKQFGAPLARSQYLQFQLADMATKLVASRLMIRTAAVALQEEREDAVALCSMAKLFATEECFAICNQALQMHGGYGYLKDYAVQQYMRDSRVHQILEGSNEVMRMLISRNLLQD | |
| transit_peptide: 1..20 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q9D7B6.2) calculated_mol_wt: 2288 peptide sequence: MAMLRSGYRRFGCLRAALKS mat_peptide: 21..413 product: Isobutyryl-CoA dehydrogenase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9D7B6.2) calculated_mol_wt: 42822 peptide sequence: LAQTHHRSITFCIDPSLGLNEEQKGFQKVAFDFAAREMAPNMAEWDQKELFPVDVMRKAAQLGFGGVYVRTDVGGSGLSRLDTSVIFEALATGCTSTTAYISIHNMCAWMIDSFGNEEQRHKFCPPLCTMEKFASYCLTEPGSGSDAASLLTSAKQQGDHYILNGSKAFISGGGESDIYVVMCRTGESGAKGISCIVVEKGTPGLSFGKKEKKVGWNSQPTRAVIFEDCAVPVANRIGTEGQGFLIAMKGLNGGRINVASCSLGAAHASVILTQEHLKVRKQFGAPLARSQYLQFQLADMATKLVASRLMIRTAAVALQEEREDAVALCSMAKLFATEECFAICNQALQMHGGYGYLKDYAVQQYMRDSRVHQILEGSNEVMRMLISRNLLQD | |
Gene Information
Entrez Gene ID
Gene Name
acyl-Coenzyme A dehydrogenase family, member 8
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005739 | IDA:MGI | C | mitochondrion |
| GO:0003995 | IEA:InterPro | F | acyl-CoA dehydrogenase activity |
| GO:0050660 | IEA:InterPro | F | flavin adenine dinucleotide binding |
| GO:0006574 | IEA:UniProtKB-UniPathway | P | valine catabolic process |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| FAO-PWY | fatty acid beta-oxidation I |
| PWY3DJ-86 | valine degradation |
| VALDEG-PWY | valine degradation I |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5892792 | Branched-chain amino acid catabolism |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR006089 | Acyl-CoA dehydrogenase, conserved site |
| IPR009075 | Acyl-CoA dehydrogenase/oxidase C-terminal |
| IPR013786 | Acyl-CoA dehydrogenase/oxidase, N-terminal |
| IPR009100 | Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain |
| IPR006091 | Acyl-CoA oxidase/dehydrogenase, central domain |
UniProt Annotations
Entry Information
Gene Name
acyl-Coenzyme A dehydrogenase family, member 8
Protein Entry
ACAD8_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Isobutyryl-CoA + ETF = methylacrylyl-CoA + reduced ETF. |
| Cofactor | Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250}; |
| Function | Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism (By similarity). {ECO:0000250}. |
| Pathway | Amino-acid degradation; L-valine degradation. |
| Sequence Caution | Sequence=BAC26664.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
| Similarity | Belongs to the acyl-CoA dehydrogenase family. {ECO:0000305}. |
| Subcellular Location | Mitochondrion {ECO:0000250}. |
| Subunit | Homotetramer, formed by a dimer of dimers. Subunit of the large multiprotein complex ARC/DRIP (By similarity). {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002218 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 118403322 | RefSeq | NP_080138 | 413 | isobutyryl-CoA dehydrogenase, mitochondrial precursor |
Identical Sequences to LMP002218 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:118403322 | DBBJ | BAC36757.1 | 413 | unnamed protein product [Mus musculus] |
| GI:118403322 | DBBJ | BAB26255.2 | 413 | unnamed protein product [Mus musculus] |
| GI:118403322 | GenBank | EDL25311.1 | 413 | acyl-Coenzyme A dehydrogenase family, member 8 [Mus musculus] |
Related Sequences to LMP002218 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:118403322 | DBBJ | BAB31764.1 | 451 | unnamed protein product [Mus musculus] |
| GI:118403322 | DBBJ | BAC26664.1 | 411 | unnamed protein product [Mus musculus] |
| GI:118403322 | DBBJ | BAC34521.1 | 413 | unnamed protein product [Mus musculus] |
| GI:118403322 | GenBank | AAH37644.1 | 413 | Acyl-Coenzyme A dehydrogenase family, member 8 [Mus musculus] |
| GI:118403322 | RefSeq | XP_003754442.1 | 411 | PREDICTED: isobutyryl-CoA dehydrogenase, mitochondrial isoform X1 [Rattus norvegicus] |
| GI:118403322 | SwissProt | Q9D7B6.2 | 413 | RecName: Full=Isobutyryl-CoA dehydrogenase, mitochondrial; AltName: Full=Acyl-CoA dehydrogenase family member 8; Short=ACAD-8; Flags: Precursor [Mus musculus] |