Gene/Proteome Database (LMPD)

LMPD ID
LMP002224
Gene ID
66885
Species
Mus musculus (Mouse)
Gene Name
acyl-Coenzyme A dehydrogenase, short/branched chain
Gene Symbol
Acadsb
Synonyms
1300003O09Rik; BB066609
Alternate Names
short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; SBCAD; 2-MEBCAD; 2-methylbutyryl-CoA dehydrogenase; 2-methylbutyryl-coenzyme A dehydrogenase; 2-methyl branched chain acyl-CoA dehydrogenase
Chromosome
7
Map Location
7|7 F4
EC Number
1.3.8.5

Proteins

short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
Refseq ID NP_080102
Protein GI 17647119
UniProt ID Q9DBL1
mRNA ID NM_025826
Length 432
RefSeq Status VALIDATED
MAVSALQLWRMGGLLRRRFPTCLSPWKIPPRVLKSSQPEALVSLTNNAVAFAPLQTLTDEEIMMKQTVKKFAQEHVAPLVSSMDENSKMEKSVIQGLFQQGLMGIEVEAQYGGTEASFFCSVLVIEELAKVDASVALLCDIQNTIINNLFRKHASEEQKATYLPKLVTEKLGSFCLSEAGAGSDSFAMKTRADKSGNYYVLNGSKMWISHAEHAELFLVFANVDPSSGYRGITCFLVDRDTEGFQIGKRENKMGIRASSTCQLTFENVKVPETNILGKIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYTIPYIKERMQFGKRIFDFQGLQHQVAQVATQLEATRLLTYNAARLVEAGRPFIKEASMAKYYASEVAGLTTSKCIEWMGGVGYTKDYPVEKFFRDAKIGTIYEGASNIQLNTIAKHIDAEY
transit_peptide: 1..33 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q9DBL1.1) calculated_mol_wt: 3851 peptide sequence: MAVSALQLWRMGGLLRRRFPTCLSPWKIPPRVL mat_peptide: 34..432 product: Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9DBL1.1) calculated_mol_wt: 44042 peptide sequence: KSSQPEALVSLTNNAVAFAPLQTLTDEEIMMKQTVKKFAQEHVAPLVSSMDENSKMEKSVIQGLFQQGLMGIEVEAQYGGTEASFFCSVLVIEELAKVDASVALLCDIQNTIINNLFRKHASEEQKATYLPKLVTEKLGSFCLSEAGAGSDSFAMKTRADKSGNYYVLNGSKMWISHAEHAELFLVFANVDPSSGYRGITCFLVDRDTEGFQIGKRENKMGIRASSTCQLTFENVKVPETNILGKIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYTIPYIKERMQFGKRIFDFQGLQHQVAQVATQLEATRLLTYNAARLVEAGRPFIKEASMAKYYASEVAGLTTSKCIEWMGGVGYTKDYPVEKFFRDAKIGTIYEGASNIQLNTIAKHIDAEY

Gene Information

Entrez Gene ID
66885
Gene Name
acyl-Coenzyme A dehydrogenase, short/branched chain
Gene Symbol
Acadsb
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005739 IDA:MGI C mitochondrion
GO:0003995 IEA:InterPro F acyl-CoA dehydrogenase activity
GO:0050660 IEA:InterPro F flavin adenine dinucleotide binding
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00071 Fatty acid degradation
mmu01212 Fatty acid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3DJ-0 isoleucine degradation

REACTOME Pathway Links

REACTOME Pathway ID Description
5892792 Branched-chain amino acid catabolism

Domain Information

InterPro Annotations

Accession Description
IPR006089 Acyl-CoA dehydrogenase, conserved site
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain

UniProt Annotations

Entry Information

Gene Name
acyl-Coenzyme A dehydrogenase, short/branched chain
Protein Entry
ACDSB_MOUSE
UniProt ID
Q9DBL1
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 2-methylbutanoyl-CoA + electron-transfer flavoprotein = (E)-2-methylbut-2-enoyl-CoA + reduced electron- transfer flavoprotein + H(+).
Catalytic Activity Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
Function Has greatest activity toward short branched chain acyl- CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl- CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent (By similarity). {ECO:0000250}.
Pathway Lipid metabolism; mitochondrial fatty acid beta- oxidation.
Similarity Belongs to the acyl-CoA dehydrogenase family. {ECO:0000305}.
Subcellular Location Mitochondrion matrix {ECO:0000305}.
Subunit Homotetramer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002224 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17647119 RefSeq NP_080102 432 short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

Identical Sequences to LMP002224 proteins

Reference Database Accession Length Protein Name
GI:17647119 DBBJ BAB23646.1 432 unnamed protein product [Mus musculus]
GI:17647119 GenBank EDL17714.1 432 acyl-Coenzyme A dehydrogenase, short/branched chain, isoform CRA_b [Mus musculus]
GI:17647119 SwissProt Q9DBL1.1 432 RecName: Full=Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; Short=SBCAD; AltName: Full=2-methyl branched chain acyl-CoA dehydrogenase; Short=2-MEBCAD; AltName: Full=2-methylbutyryl-coenzyme A dehydrogenase; Short=2-methylbutyryl-CoA dehydrogenase; Flags: Precursor [Mus musculus]

Related Sequences to LMP002224 proteins

Reference Database Accession Length Protein Name
GI:17647119 GenBank AAB17136.1 432 short-branched chain acyl-CoA dehydrogenase precursor [Rattus norvegicus]
GI:17647119 GenBank AAH54428.1 432 Acyl-Coenzyme A dehydrogenase, short/branched chain [Mus musculus]
GI:17647119 GenBank EDL17713.1 480 acyl-Coenzyme A dehydrogenase, short/branched chain, isoform CRA_a, partial [Mus musculus]
GI:17647119 GenBank EDM11701.1 432 acyl-Coenzyme A dehydrogenase, short/branched chain, isoform CRA_b [Rattus norvegicus]
GI:17647119 RefSeq NP_037216.1 432 short/branched chain specific acyl-CoA dehydrogenase, mitochondrial [Rattus norvegicus]
GI:17647119 SwissProt P70584.1 432 RecName: Full=Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; Short=SBCAD; AltName: Full=2-methyl branched chain acyl-CoA dehydrogenase; Short=2-MEBCAD; AltName: Full=2-methylbutyryl-coenzyme A dehydrogenase; Short=2-methylbutyryl-CoA dehydrogenase; Flags: Precursor [Rattus norvegicus]