Gene/Proteome Database (LMPD)

LMPD ID
LMP002234
Gene ID
4023
Species
Homo sapiens (Human)
Gene Name
lipoprotein lipase
Gene Symbol
LPL
Synonyms
HDLCQ11; LIPD
Alternate Names
lipoprotein lipase
Chromosome
8
Map Location
8p22
EC Number
3.1.1.34
Summary
LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for LPL

Proteins

lipoprotein lipase precursor
Refseq ID NP_000228
Protein GI 4557727
UniProt ID P06858
mRNA ID NM_000237
Length 475
RefSeq Status REVIEWED
MESKALLVLTLAVWLQSLTASRGGVAAADQRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLNKKSG
sig_peptide: 1..27 calculated_mol_wt: 2786 peptide sequence: MESKALLVLTLAVWLQSLTASRGGVAA mat_peptide: 28..475 product: lipoprotein lipase calculated_mol_wt: 50394 peptide sequence: ADQRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLNKKSG

Gene Information

Entrez Gene ID
4023
Gene Name
lipoprotein lipase
Gene Symbol
LPL
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031225 IEA:UniProtKB-KW C anchored component of membrane
GO:0009986 IEA:Ensembl C cell surface
GO:0042627 IEA:UniProtKB-KW C chylomicron
GO:0031012 IEA:Ensembl C extracellular matrix
GO:0005576 TAS:Reactome C extracellular region
GO:0005615 IDA:BHF-UCL C extracellular space
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0034361 IEA:UniProtKB-KW C very-low-density lipoprotein particle
GO:0034185 IPI:BHF-UCL F apolipoprotein binding
GO:0008201 IDA:BHF-UCL F heparin binding
GO:0004465 IDA:BHF-UCL F lipoprotein lipase activity
GO:0004620 ISS:BHF-UCL F phospholipase activity
GO:0005102 IPI:BHF-UCL F receptor binding
GO:0017129 IEA:Ensembl F triglyceride binding
GO:0004806 IDA:BHF-UCL F triglyceride lipase activity
GO:0034371 IC:BHF-UCL P chylomicron remodeling
GO:0006633 IDA:BHF-UCL P fatty acid biosynthetic process
GO:0042157 TAS:Reactome P lipoprotein metabolic process
GO:0006644 ISS:BHF-UCL P phospholipid metabolic process
GO:0007603 TAS:Reactome P phototransduction, visible light
GO:0010886 IMP:BHF-UCL P positive regulation of cholesterol storage
GO:0010744 IC:BHF-UCL P positive regulation of macrophage derived foam cell differentiation
GO:0010890 IMP:BHF-UCL P positive regulation of sequestering of triglyceride
GO:0009409 IEA:Ensembl P response to cold
GO:0042493 IEA:Ensembl P response to drug
GO:0001523 TAS:Reactome P retinoid metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0019432 IEA:Ensembl P triglyceride biosynthetic process
GO:0019433 IDA:BHF-UCL P triglyceride catabolic process
GO:0070328 IGI:BHF-UCL P triglyceride homeostasis
GO:0006641 ISS:BHF-UCL P triglyceride metabolic process
GO:0034372 IDA:BHF-UCL P very-low-density lipoprotein particle remodeling

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR013818 Lipase, N-terminal
IPR002330 Lipoprotein lipase
IPR016272 Lipoprotein_lipase_LIPH
IPR001024 PLAT/LH2 domain
IPR000734 Triacylglycerol lipase family

UniProt Annotations

Entry Information

Gene Name
lipoprotein lipase
Protein Entry
LIPL_HUMAN
UniProt ID
P06858
Species
Human

Comments

Comment Type Description
Catalytic Activity Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
Disease Lipoprotein lipase deficiency (LPL deficiency) [MIM
Function The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity).
Ptm Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
Similarity Belongs to the AB hydrolase superfamily. Lipase family.
Similarity Contains 1 PLAT domain. {ECO
Subcellular Location Cell membrane ; Lipid-anchor, GPI-anchor {ECO
Subunit Homodimer (By similarity). Interacts with APOC2; the interaction activates LPL activity in the presence of lipids. Interacts with GPIHBP1. {ECO
Web Resource Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=LPL";
Web Resource Name=Wikipedia; Note=Lipoprotein lipase entry; URL="http://en.wikipedia.org/wiki/Lipoprotein_lipase";

Identical and Related Proteins

Unique RefSeq proteins for LMP002234 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4557727 RefSeq NP_000228 475 lipoprotein lipase precursor

Identical Sequences to LMP002234 proteins

Reference Database Accession Length Protein Name
GI:4557727 DBBJ BAG35236.1 475 unnamed protein product [Homo sapiens]
GI:4557727 GenBank ACP57177.1 475 Sequence 1306 from patent US 7482117
GI:4557727 GenBank ACW42904.1 475 Sequence 13 from patent US 7579447
GI:4557727 GenBank ADS30774.1 475 Sequence 1306 from patent US 7781168
GI:4557727 GenBank AGN45442.1 475 Sequence 13 from patent US 8343494
GI:4557727 GenBank AHD73094.1 475 Sequence 10162 from patent US 8586006

Related Sequences to LMP002234 proteins

Reference Database Accession Length Protein Name
GI:4557727 DBBJ BAD96184.1 475 lipoprotein lipase precursor variant, partial [Homo sapiens]
GI:4557727 DBBJ BAF82979.1 475 unnamed protein product [Homo sapiens]
GI:4557727 GenBank AAX31947.1 475 lipoprotein lipase [synthetic construct]
GI:4557727 GenBank JAA19558.1 475 lipoprotein lipase [Pan troglodytes]
GI:4557727 RefSeq XP_001149804.1 475 PREDICTED: lipoprotein lipase [Pan troglodytes]
GI:4557727 RefSeq XP_003823674.1 475 PREDICTED: lipoprotein lipase [Pan paniscus]