Gene/Proteome Database (LMPD)

LMPD ID
LMP002238
Gene ID
27399
Species
Mus musculus (Mouse)
Gene Name
inositol hexaphosphate kinase 1
Gene Symbol
Ip6k1
Synonyms
1200016D08Rik; AU022776; Ihpk1; InsP6; InsP6k1; Itpk6
Alternate Names
inositol hexakisphosphate kinase 1; insP6 kinase 1; inositol hexakisphosphate kinase 6
Chromosome
9
Map Location
9 F2|9
EC Number
2.7.4.21

Proteins

inositol hexakisphosphate kinase 1
Refseq ID NP_038813
Protein GI 40254568
UniProt ID Q6PD10
mRNA ID NM_013785
Length 433
RefSeq Status PROVISIONAL
MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDDHTVCKPLISREQRFYESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETVEQDDTPEREQPRRKHSRRSLHRSGSGSDHKEEKASLSFETSESSQEAKSPKVELHSHSDVPFQMLDSNSGLSSEKISYNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFKYPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSATLGVRVCGMQVYQLDTGHYLCRNKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSSLLVIYDGKECRSELRLKHVDMGLPEVPPPCGPSTSPSSTSLEAGPSSPPKVDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQMRDENQ

Gene Information

Entrez Gene ID
27399
Gene Name
inositol hexaphosphate kinase 1
Gene Symbol
Ip6k1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:MGI C cytoplasm
GO:0005730 IEA:Ensembl C nucleolus
GO:0005634 IDA:MGI C nucleus
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0052723 IEA:UniProtKB-EC F inositol hexakisphosphate 1-kinase activity
GO:0052724 IEA:UniProtKB-EC F inositol hexakisphosphate 3-kinase activity
GO:0000832 IEA:UniProtKB-EC F inositol hexakisphosphate 5-kinase activity
GO:0008440 IEA:InterPro F inositol-1,4,5-trisphosphate 3-kinase activity
GO:0006020 ISA:MGI P inositol metabolic process
GO:0032958 ISA:MGI P inositol phosphate biosynthetic process
GO:0046854 ISS:UniProtKB P phosphatidylinositol phosphorylation

REACTOME Pathway Links

REACTOME Pathway ID Description
5894026 Inositol phosphate metabolism
5892760 Metabolism
5894028 Synthesis of IPs in the nucleus
5894029 Synthesis of pyrophosphates in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR005522 Inositol polyphosphate kinase

UniProt Annotations

Entry Information

Gene Name
inositol hexaphosphate kinase 1
Protein Entry
IP6K1_MOUSE
UniProt ID
Q6PD10
Species
Mouse

Comments

Comment Type Description
Catalytic Activity ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
Catalytic Activity ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
Function Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. {ECO:0000269|PubMed:10574768}.
Similarity Belongs to the inositol phosphokinase (IPK) family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue Specificity Highly expressed in brain and testis. Detected at much lower levels in heart, kidney, liver, lung and spleen. {ECO:0000269|PubMed:10574768}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002238 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
40254568 RefSeq NP_038813 433 inositol hexakisphosphate kinase 1

Identical Sequences to LMP002238 proteins

Reference Database Accession Length Protein Name
GI:40254568 GenBank AAH59006.1 433 Inositol hexaphosphate kinase 1 [Mus musculus]
GI:40254568 GenBank EDL21257.1 433 mCG18852 [Mus musculus]
GI:40254568 SwissProt Q6PD10.1 433 RecName: Full=Inositol hexakisphosphate kinase 1; Short=InsP6 kinase 1; AltName: Full=Inositol hexaphosphate kinase 1 [Mus musculus]

Related Sequences to LMP002238 proteins

Reference Database Accession Length Protein Name
GI:40254568 DBBJ BAB13737.1 433 inositol hexakisphosphate kinase [Rattus norvegicus]
GI:40254568 DBBJ BAD32199.1 454 mKIAA0263 protein, partial [Mus musculus]
GI:40254568 GenBank AAF15056.1 433 mammalian inositol hexakisphosphate kinase 1 [Mus musculus]
GI:40254568 RefSeq XP_003500391.1 433 PREDICTED: inositol hexakisphosphate kinase 1 [Cricetulus griseus]
GI:40254568 RefSeq XP_006978398.1 433 PREDICTED: inositol hexakisphosphate kinase 1 [Peromyscus maniculatus bairdii]
GI:40254568 RefSeq XP_007633007.1 433 PREDICTED: inositol hexakisphosphate kinase 1 [Cricetulus griseus]