Gene/Proteome Database (LMPD)
LMPD ID
LMP002241
Gene ID
Species
Homo sapiens (Human)
Gene Name
DDHD domain containing 1
Gene Symbol
Synonyms
PA-PLA1; PAPLA1; SPG28
Alternate Names
phospholipase DDHD1; DDHD domain-containing protein 1; spastic paraplegia 28 (autosomal recessive); phosphatidic acid-preferring phospholipase A1 homolog; phosphatidic acid-preferring phospholipase A1-like protein
Chromosome
14
Map Location
14q21
EC Number
3.1.1.-
Proteins
| phospholipase DDHD1 isoform a | |
|---|---|
| Refseq ID | NP_085140 |
| Protein GI | 237757342 |
| UniProt ID | Q8NEL9 |
| mRNA ID | NM_030637 |
| Length | 872 |
| RefSeq Status | VALIDATED |
| MNYPGRGSPRSPEHNGRGGGGGAWELGSDARPAFGGGVCCFEHLPGGDPDDGDVPLALLRGEPGLHLAPGTDDHNHHLALDPCLSDENYDFSSAESGSSLRYYSEGESGGGGSSLSLHPPQQPPLVPTNSGGGGATGGSPGERKRTRLGGPAARHRYEVVTELGPEEVRWFYKEDKKTWKPFIGYDSLRIELAFRTLLQTTGARPQGGDRDGDHVCSPTGPASSSGEDDDEDRACGFCQSTTGHEPEMVELVNIEPVCVRGGLYEVDVTQGECYPVYWNQADKIPVMRGQWFIDGTWQPLEEEESNLIEQEHLNCFRGQQMQENFDIEVSKSIDGKDAVHSFKLSRNHVDWHSVDEVYLYSDATTSKIARTVTQKLGFSKASSSGTRLHRGYVEEATLEDKPSQTTHIVFVVHGIGQKMDQGRIIKNTAMMREAARKIEERHFSNHATHVEFLPVEWRSKLTLDGDTVDSITPDKVRGLRDMLNSSAMDIMYYTSPLYRDELVKGLQQELNRLYSLFCSRNPDFEEKGGKVSIVSHSLGCVITYDIMTGWNPVRLYEQLLQKEEELPDERWMSYEERHLLDELYITKRRLKEIEERLHGLKASSMTQTPALKFKVENFFCMGSPLAVFLALRGIRPGNTGSQDHILPREICNRLLNIFHPTDPVAYRLEPLILKHYSNISPVQIHWYNTSNPLPYEHMKPSFLNPAKEPTSVSENEGISTIPSPVTSPVLSRRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSTTQSSETSKDSMEDEKKPVASPSATTVGTQTLPHSSSGFLDSALELDHRIDFELREGLVESRYWSAVTSHTAYWSSLDVALFLLTFMYKHEHDDDAKPNLDPI | |
| phospholipase DDHD1 isoform b | |
|---|---|
| Refseq ID | NP_001153619 |
| Protein GI | 237757344 |
| UniProt ID | Q8NEL9 |
| mRNA ID | NM_001160147 |
| Length | 879 |
| RefSeq Status | VALIDATED |
| MNYPGRGSPRSPEHNGRGGGGGAWELGSDARPAFGGGVCCFEHLPGGDPDDGDVPLALLRGEPGLHLAPGTDDHNHHLALDPCLSDENYDFSSAESGSSLRYYSEGESGGGGSSLSLHPPQQPPLVPTNSGGGGATGGSPGERKRTRLGGPAARHRYEVVTELGPEEVRWFYKEDKKTWKPFIGYDSLRIELAFRTLLQTTGARPQGGDRDGDHVCSPTGPASSSGEDDDEDRACGFCQSTTGHEPEMVELVNIEPVCVRGGLYEVDVTQGECYPVYWNQADKIPVMRGQWFIDGTWQPLEEEESNLIEQEHLNCFRGQQMQENFDIEVSKSIDGKDGSGINYSAVHSFKLSRNHVDWHSVDEVYLYSDATTSKIARTVTQKLGFSKASSSGTRLHRGYVEEATLEDKPSQTTHIVFVVHGIGQKMDQGRIIKNTAMMREAARKIEERHFSNHATHVEFLPVEWRSKLTLDGDTVDSITPDKVRGLRDMLNSSAMDIMYYTSPLYRDELVKGLQQELNRLYSLFCSRNPDFEEKGGKVSIVSHSLGCVITYDIMTGWNPVRLYEQLLQKEEELPDERWMSYEERHLLDELYITKRRLKEIEERLHGLKASSMTQTPALKFKVENFFCMGSPLAVFLALRGIRPGNTGSQDHILPREICNRLLNIFHPTDPVAYRLEPLILKHYSNISPVQIHWYNTSNPLPYEHMKPSFLNPAKEPTSVSENEGISTIPSPVTSPVLSRRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSTTQSSETSKDSMEDEKKPVASPSATTVGTQTLPHSSSGFLDSALELDHRIDFELREGLVESRYWSAVTSHTAYWSSLDVALFLLTFMYKHEHDDDAKPNLDPI | |
| phospholipase DDHD1 isoform c | |
|---|---|
| Refseq ID | NP_001153620 |
| Protein GI | 237757346 |
| UniProt ID | Q8NEL9 |
| mRNA ID | NM_001160148 |
| Length | 900 |
| RefSeq Status | VALIDATED |
| MNYPGRGSPRSPEHNGRGGGGGAWELGSDARPAFGGGVCCFEHLPGGDPDDGDVPLALLRGEPGLHLAPGTDDHNHHLALDPCLSDENYDFSSAESGSSLRYYSEGESGGGGSSLSLHPPQQPPLVPTNSGGGGATGGSPGERKRTRLGGPAARHRYEVVTELGPEEVRWFYKEDKKTWKPFIGYDSLRIELAFRTLLQTTGARPQGGDRDGDHVCSPTGPASSSGEDDDEDRACGFCQSTTGHEPEMVELVNIEPVCVRGGLYEVDVTQGECYPVYWNQADKIPVMRGQWFIDGTWQPLEEEESNLIEQEHLNCFRGQQMQENFDIEVSKSIDGKDAVHSFKLSRNHVDWHSVDEVYLYSDATTSKIARTVTQKLGFSKASSSGTRLHRGYVEEATLEDKPSQTTHIVFVVHGIGQKMDQGRIIKNTAMMREAARKIEERHFSNHATHVEFLPVEWRSKLTLDGDTVDSITPDKVRGLRDMLNSSAMDIMYYTSPLYRDELVKGLQQELNRLYSLFCSRNPDFEEKGGKVSIVSHSLGCVITYDIMTGWNPVRLYEQLLQKEEELPDERWMSYEERHLLDELYITKRRLKEIEERLHGLKASSMTQTPALKFKVENFFCMGSPLAVFLALRGIRPGNTGSQDHILPREICNRLLNIFHPTDPVAYRLEPLILKHYSNISPVQIHWYNTSNPLPYEHMKPSFLNPAKEPTSVSENEGISTIPSPVTSPVLSRRHYGESITNIGKASILGAASIGKGLGGMLFSRFGRSSTTQSSETSKDSMEDEKKPVASPSATTVGTQTLPHSSSGFLDSAYFRLQESFFNLPQLLFPENVMQNKDNALVELDHRIDFELREGLVESRYWSAVTSHTAYWSSLDVALFLLTFMYKHEHDDDAKPNLDPI | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IEA:UniProtKB-KW | C | cytoplasm |
| GO:0016787 | IEA:UniProtKB-KW | F | hydrolase activity |
| GO:0046872 | IEA:InterPro | F | metal ion binding |
| GO:0008219 | IEA:UniProtKB-KW | P | cell death |
| GO:0016042 | IEA:UniProtKB-KW | P | lipid catabolic process |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR004177 | DDHD |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8NEL9-1; Sequence=Displayed; Name=2; IsoId=Q8NEL9-2; Sequence=VSP_008629; Name=3; IsoId=Q8NEL9-3; Sequence=VSP_008628, VSP_008629; Note=No experimental confirmation available.; Name=4; IsoId=Q8NEL9-4; Sequence=VSP_045340, VSP_008629; Note=No experimental confirmation available.; |
| Disease | Spastic paraplegia 28, autosomal recessive (SPG28) [MIM |
| Function | Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity. |
| Sequence Caution | Sequence=BAB21796.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=BAB71679.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; |
| Similarity | Belongs to the PA-PLA1 family. |
| Similarity | Contains 1 DDHD domain. {ECO |
| Subcellular Location | Cytoplasm . |
| Subunit | Forms homooligomers and, to a much smaller extent, heterooligomers with DDHD2. |
| Tissue Specificity | Highly expressed in testis. Also expressed in brain, spleen and lung. Only expressed in cerebellum in fetal brain. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002241 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 237757342 | RefSeq | NP_085140 | 872 | phospholipase DDHD1 isoform a |
| 237757344 | RefSeq | NP_001153619 | 879 | phospholipase DDHD1 isoform b |
| 237757346 | RefSeq | NP_001153620 | 900 | phospholipase DDHD1 isoform c |
Identical Sequences to LMP002241 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:237757342 | GenBank | EAW80622.1 | 872 | DDHD domain containing 1, isoform CRA_b [Homo sapiens] |
| GI:237757344 | GenBank | EAW80623.1 | 879 | DDHD domain containing 1, isoform CRA_c [Homo sapiens] |
| GI:237757346 | SwissProt | Q8NEL9.2 | 900 | RecName: Full=Phospholipase DDHD1; AltName: Full=DDHD domain-containing protein 1; AltName: Full=Phosphatidic acid-preferring phospholipase A1 homolog; Short=PA-PLA1 [Homo sapiens] |
Related Sequences to LMP002241 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:237757342 | GenBank | AAH30703.1 | 872 | DDHD domain containing 1 [Homo sapiens] |
| GI:237757342 | GenBank | ABJ29145.1 | 874 | Sequence 2 from patent US 7094587 |
| GI:237757346 | GenBank | ABJ29146.1 | 902 | Sequence 5 from patent US 7094587 |
| GI:237757344 | GenBank | EAW80622.1 | 872 | DDHD domain containing 1, isoform CRA_b [Homo sapiens] |
| GI:237757342 | GenBank | EAW80623.1 | 879 | DDHD domain containing 1, isoform CRA_c [Homo sapiens] |
| GI:237757346 | GenBank | ACC31952.1 | 902 | Sequence 5 from patent US 7351566 |
| GI:237757346 | GenBank | ADA32150.1 | 902 | Sequence 5 from patent US 7611879 |
| GI:237757346 | GenBank | AEC30910.1 | 902 | Sequence 5 from patent US 7867729 |
| GI:237757344 | GenBank | AHD77541.1 | 872 | Sequence 23670 from patent US 8586006 |
| GI:237757342 | GenBank | AHD77541.1 | 872 | Sequence 23670 from patent US 8586006 |
| GI:237757342 | GenBank | AIC57203.1 | 872 | DDHD1, partial [synthetic construct] |
| GI:237757344 | RefSeq | XP_001159988.1 | 883 | PREDICTED: phospholipase DDHD1 isoform X6 [Pan troglodytes] |
| GI:237757344 | RefSeq | NP_085140.2 | 872 | phospholipase DDHD1 isoform a [Homo sapiens] |
| GI:237757342 | RefSeq | NP_001153619.1 | 879 | phospholipase DDHD1 isoform b [Homo sapiens] |
| GI:237757344 | RefSeq | XP_003831751.1 | 880 | PREDICTED: phospholipase DDHD1 isoform X5 [Pan paniscus] |
| GI:237757346 | RefSeq | XP_003831752.1 | 901 | PREDICTED: phospholipase DDHD1 isoform X4 [Pan paniscus] |
| GI:237757346 | RefSeq | XP_005268160.1 | 907 | PREDICTED: phospholipase DDHD1 isoform X2 [Homo sapiens] |
| GI:237757344 | RefSeq | XP_005268160.1 | 907 | PREDICTED: phospholipase DDHD1 isoform X2 [Homo sapiens] |