Gene/Proteome Database (LMPD)

LMPD ID
LMP002242
Gene ID
241447
Species
Mus musculus (Mouse)
Gene Name
ceramide synthase 6
Gene Symbol
Cers6
Synonyms
4732462C07Rik; AW544719; Lass6; T1L
Alternate Names
ceramide synthase 6; longevity assurance homolog 6; LAG1 homolog, ceramide synthase 6; LAG1 longevity assurance homolog 6
Chromosome
2
Map Location
2 C2|2

Proteins

ceramide synthase 6
Refseq ID NP_766444
Protein GI 27370296
UniProt ID Q8C172
mRNA ID NM_172856
Length 384
RefSeq Status PROVISIONAL
MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFIAKPCAIALNIQANGPQTAQPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFSYGVRFLKQTPWLWNTRHCWYNYPYQPLTADLHYYYILELSFYWSLMVSQFTDIKRKDFGIMFLHHLATIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLLLQGLNCFWSYLIVKIACKTVSKGKVSKDDRSDIESSSDDEDSEPPGKKPHSSTTTNGTSGTNGYLLTGPCSVDD

Gene Information

Entrez Gene ID
241447
Gene Name
ceramide synthase 6
Gene Symbol
Cers6
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:MGI C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0003677 IEA:UniProtKB-KW F DNA binding
GO:0050291 IDA:MGI F sphingosine N-acyltransferase activity
GO:0046513 IDA:MGI P ceramide biosynthetic process
GO:0030148 IDA:MGI P sphingolipid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00600 Sphingolipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3DJ-12 ceramide biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR016439 Longevity assurance, LAG1/LAC1
IPR006634 TRAM/LAG1/CLN8 homology domain

UniProt Annotations

Entry Information

Gene Name
ceramide synthase 6
Protein Entry
CERS6_MOUSE
UniProt ID
Q8C172
Species
Mouse

Comments

Comment Type Description
Function May be involved in sphingolipid synthesis or its regulation. {ECO:0000269|PubMed:15823095}.
Ptm Glycosylation on Asn-18 is not necessary for function. {ECO:0000269|PubMed:15823095}.
Similarity Contains 1 TLC (TRAM/LAG1/CLN8) domain. {ECO:0000255|PROSITE-ProRule:PRU00205}.
Similarity Contains 1 homeobox DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00108}.
Subcellular Location Nucleus membrane {ECO:0000255|PROSITE- ProRule:PRU00108}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15823095}; Multi-pass membrane protein {ECO:0000269|PubMed:15823095}.
Tissue Specificity Broadly expressed, with highest levels in kidney and brain. {ECO:0000269|PubMed:15823095}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002242 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
27370296 RefSeq NP_766444 384 ceramide synthase 6

Identical Sequences to LMP002242 proteins

Reference Database Accession Length Protein Name
GI:27370296 DBBJ BAC26153.1 384 unnamed protein product [Mus musculus]
GI:27370296 DBBJ BAE30739.1 384 unnamed protein product [Mus musculus]
GI:27370296 DBBJ BAE31202.1 384 unnamed protein product [Mus musculus]
GI:27370296 GenBank AAH57629.1 384 LAG1 homolog, ceramide synthase 6 [Mus musculus]
GI:27370296 GenBank EDL27024.1 384 longevity assurance homolog 6 (S. cerevisiae) [Mus musculus]
GI:27370296 SwissProt Q8C172.1 384 RecName: Full=Ceramide synthase 6; Short=CerS6; AltName: Full=LAG1 longevity assurance homolog 6 [Mus musculus]

Related Sequences to LMP002242 proteins

Reference Database Accession Length Protein Name
GI:27370296 GenBank EDL79047.1 384 similar to longevity assurance homolog 6 (predicted) [Rattus norvegicus]
GI:27370296 RefSeq XP_001058317.2 384 PREDICTED: ceramide synthase 6 isoform X2 [Rattus norvegicus]
GI:27370296 RefSeq XP_345364.5 384 PREDICTED: ceramide synthase 6 isoform X2 [Rattus norvegicus]
GI:27370296 RefSeq XP_006224534.1 392 PREDICTED: ceramide synthase 6 isoform X1 [Rattus norvegicus]
GI:27370296 RefSeq XP_006234370.1 392 PREDICTED: ceramide synthase 6 isoform X1 [Rattus norvegicus]
GI:27370296 RefSeq XP_006499515.1 392 PREDICTED: ceramide synthase 6 isoform X1 [Mus musculus]