Gene/Proteome Database (LMPD)
LMPD ID
LMP002244
Gene ID
Species
Homo sapiens (Human)
Gene Name
alcohol dehydrogenase 1C (class I), gamma polypeptide
Gene Symbol
Synonyms
ADH3
Alternate Names
alcohol dehydrogenase 1C; ADH, gamma subunit; aldehyde reductase; alcohol dehydrogenase 3 (class I), gamma polypeptide
Chromosome
4
Map Location
4q23
EC Number
1.1.1.1
Summary
This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| alcohol dehydrogenase 1C | |
|---|---|
| Refseq ID | NP_000660 |
| Protein GI | 4501933 |
| UniProt ID | P00326 |
| mRNA ID | NM_000669 |
| Length | 375 |
| RefSeq Status | REVIEWED |
| MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNILPFEKINEGFDLLRSGKSIRTVLTF | |
Gene Information
Entrez Gene ID
Gene Name
alcohol dehydrogenase 1C (class I), gamma polypeptide
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0004022 | IDA:UniProtKB | F | alcohol dehydrogenase (NAD) activity |
| GO:0008270 | IEA:InterPro | F | zinc ion binding |
| GO:0006069 | IDA:UniProtKB | P | ethanol oxidation |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0006805 | TAS:Reactome | P | xenobiotic metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa05204 | Chemical carcinogenesis |
| hsa00982 | Drug metabolism - cytochrome P450 |
| hsa00010 | Glycolysis / Gluconeogenesis |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_34 | Ethanol oxidation |
Domain Information
InterPro Annotations
UniProt Annotations
Entry Information
Gene Name
alcohol dehydrogenase 1C (class I), gamma polypeptide
Protein Entry
ADH1G_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | An alcohol + NAD(+) = an aldehyde or ketone + NADH. |
| Caution | The reference genome assembly, GRCh37, describes a non- functional copy of that gene with a stop codon at position 78. However, this premature stop codon is not present in available mRNAs. |
| Cofactor | Name=Zn(2+); Xref=ChEBI |
| Miscellaneous | There are 7 different ADH's isozymes in human: three belongs to class-I |
| Polymorphism | Two main alleles are known, ADH3*1 or gamma-1 has Arg-272/Ile-350 while ADH3*2 or gamma-2 has Gln-272/Val-350. ADH3*1 is associated with a fast rate of ethanol oxidation and ADH3*2 with a slow rate. |
| Similarity | Belongs to the zinc-containing alcohol dehydrogenase family. |
| Subcellular Location | Cytoplasm. |
| Subunit | Dimer of identical or non-identical chains of three types; alpha, beta and gamma. {ECO |
| Web Resource | Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/adh1c/"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP002244 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 4501933 | RefSeq | NP_000660 | 375 | alcohol dehydrogenase 1C |
Identical Sequences to LMP002244 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4501933 | GenBank | AAH74771.1 | 375 | Class I alcohol dehydrogenase, gamma subunit [Homo sapiens] |
| GI:4501933 | GenBank | AAY68222.1 | 375 | alcohol dehydrogenase 1C (class I), gamma polypeptide [Homo sapiens] |
| GI:4501933 | GenBank | EAX06100.1 | 375 | alcohol dehydrogenase 1C (class I), gamma polypeptide, isoform CRA_b [Homo sapiens] |
| GI:4501933 | GenBank | ADR87072.1 | 375 | Sequence 318 from patent US 7740664 |
| GI:4501933 | GenBank | AHE01096.1 | 375 | Sequence 56012 from patent US 8586006 |
| GI:4501933 | GenBank | AIC53960.1 | 375 | ADH1C, partial [synthetic construct] |
Related Sequences to LMP002244 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4501933 | EMBL | CAA27842.1 | 375 | unnamed protein product [Homo sapiens] |
| GI:4501933 | GenBank | AAH62476.1 | 375 | Alcohol dehydrogenase 1C (class I), gamma polypeptide [Homo sapiens] |
| GI:4501933 | GenBank | AAH66227.1 | 375 | Alcohol dehydrogenase 1C (class I), gamma polypeptide [Homo sapiens] |
| GI:4501933 | GenBank | AAH67419.1 | 375 | Class I alcohol dehydrogenase, gamma subunit [Homo sapiens] |
| GI:4501933 | RefSeq | XP_003829975.1 | 375 | PREDICTED: alcohol dehydrogenase 1C [Pan paniscus] |
| GI:4501933 | RefSeq | XP_004040222.1 | 375 | PREDICTED: alcohol dehydrogenase 1C [Gorilla gorilla gorilla] |