Gene/Proteome Database (LMPD)

LMPD ID
LMP002248
Gene ID
11522
Species
Mus musculus (Mouse)
Gene Name
alcohol dehydrogenase 1 (class I)
Gene Symbol
Adh1
Synonyms
ADH-AA; AI194826; Adh-1; Adh-1-t; Adh-1e; Adh-1t; Adh-3e; Adh1-e; Adh1-t; Adh1tl; Adh3-e
Alternate Names
alcohol dehydrogenase 1; ADH-A2; class I alcohol dehydrogenase; alcohol dehydrogenase A subunit; alcohol dehydrogenase 1, complex; alcohol dehydrogenase 1 temporal, liver; alcohol dehydrogenase 1, electrophoretic; alcohol dehydrogenase 3, electrophoretic
Chromosome
3
Map Location
3 G3|3 64.16 cM
EC Number
1.1.1.1

Proteins

alcohol dehydrogenase 1
Refseq ID NP_031435
Protein GI 6724311
UniProt ID P00329
mRNA ID NM_007409
Length 375
RefSeq Status PROVISIONAL
MSTAGKVIKCKAAVLWELHKPFTIEDIEVAPPKAHEVRIKMVATGVCRSDDHVVSGTLVTPLPAVLGHEGAGIVESVGEGVTCVKPGDKVIPLFSPQCGECRICKHPESNFCSRSDLLMPRGTLREGTSRFSCKGKQIHNFISTSTFSQYTVVDDIAVAKIDGASPLDKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVIIGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYSKPIQEVLQEMTDGGVDFSFEVIGRLDTMTSALLSCHAACGVSVVVGVPPNAQNLSMNPMLLLLGRTWKGAIFGGFKSKDSVPKLVADFMAKKFPLDPLITHVLPFEKINEAFDLLRSGKSIRTVLTF

Gene Information

Entrez Gene ID
11522
Gene Name
alcohol dehydrogenase 1 (class I)
Gene Symbol
Adh1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005622 IDA:MGI C intracellular
GO:0005739 IDA:MGI C mitochondrion
GO:0004022 IDA:MGI F alcohol dehydrogenase (NAD) activity
GO:0042803 IPI:MGI F protein homodimerization activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0048149 IMP:MGI P behavioral response to ethanol
GO:0006068 IDA:MGI P ethanol catabolic process
GO:0032526 IDA:MGI P response to retinoic acid
GO:0048545 IDA:MGI P response to steroid hormone
GO:0033574 IDA:MGI P response to testosterone
GO:0042573 IMP:MGI P retinoic acid metabolic process
GO:0001523 IMP:MGI P retinoid metabolic process
GO:0042572 IMP:MGI P retinol metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu05204 Chemical carcinogenesis
mmu00010 Glycolysis / Gluconeogenesis

Domain Information

InterPro Annotations

Accession Description
IPR013154 Alcohol dehydrogenase GroES-like
IPR002085 Alcohol dehydrogenase superfamily, zinc-type
IPR013149 Alcohol dehydrogenase, C-terminal
IPR002328 Alcohol dehydrogenase, zinc-type, conserved site
IPR011032 GroES (chaperonin 10)-like
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
alcohol dehydrogenase 1 (class I)
Protein Entry
ADH1_MOUSE
UniProt ID
P00329
Species
Mouse

Comments

Comment Type Description
Catalytic Activity An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
Similarity Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily. {ECO:0000305}.
Subcellular Location Cytoplasm.
Subunit Dimer of identical or non-identical chains of three types (A, B, C), which are coded by 3 separate genes at different loci.
Tissue Specificity Expressed at high levels in the liver, small intestine and eye, at moderate levels in kidney, ovary and uterus, and at low levels in the spinal cord, thymus, heart, stomach mucosa, skin and testis. {ECO:0000269|PubMed:7738026}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002248 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6724311 RefSeq NP_031435 375 alcohol dehydrogenase 1

Identical Sequences to LMP002248 proteins

Reference Database Accession Length Protein Name
GI:6724311 DBBJ BAE26897.1 375 unnamed protein product [Mus musculus]
GI:6724311 GenBank AAA37178.1 375 alcohol dehydrogenase, partial [Mus musculus]
GI:6724311 GenBank AAA37179.1 375 alcohol dehydrogenase, partial [Mus musculus]
GI:6724311 GenBank AAH13477.1 375 Alcohol dehydrogenase 1 (class I) [Mus musculus]
GI:6724311 GenBank AAH54467.1 375 Alcohol dehydrogenase 1 (class I) [Mus musculus]
GI:6724311 GenBank EDL12102.1 375 alcohol dehydrogenase 1 (class I), isoform CRA_c [Mus musculus]

Related Sequences to LMP002248 proteins

Reference Database Accession Length Protein Name
GI:6724311 GenBank AAA85462.1 376 alcohol dehydrogenase [Rattus norvegicus]
GI:6724311 GenBank AAA40591.1 375 alcohol dehydrogenase 1 [Peromyscus maniculatus]
GI:6724311 GenBank AAE28482.1 374 Sequence 85 from patent US 5958784
GI:6724311 GenBank AAH62403.1 376 Alcohol dehydrogenase 1 (class I) [Rattus norvegicus]
GI:6724311 SwissProt P06757.3 376 RecName: Full=Alcohol dehydrogenase 1; AltName: Full=Alcohol dehydrogenase A subunit [Rattus norvegicus]
GI:6724311 SwissProt P41680.2 375 RecName: Full=Alcohol dehydrogenase 1; AltName: Full=Alcohol dehydrogenase A subunit [Peromyscus maniculatus]