Gene/Proteome Database (LMPD)

LMPD ID
LMP002255
Gene ID
1241
Species
Homo sapiens (Human)
Gene Name
leukotriene B4 receptor
Gene Symbol
LTB4R
Synonyms
BLT1; BLTR; CMKRL1; GPR16; LTB4R1; LTBR1; P2RY7; P2Y7
Alternate Names
leukotriene B4 receptor 1; LTB4-R1; LTB4-R 1; P2Y purinoceptor 7; chemokine receptor-like 1; G protein-coupled receptor 16; G-protein coupled receptor 16; chemoattractant receptor-like 1; purinergic receptor P2Y, G-protein coupled, 7
Chromosome
14
Map Location
14q11.2-q12

Proteins

leukotriene B4 receptor 1
Refseq ID NP_001137391
Protein GI 221218998
UniProt ID Q15722
mRNA ID NM_001143919
Length 352
RefSeq Status VALIDATED
MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
leukotriene B4 receptor 1
Refseq ID NP_858043
Protein GI 31881792
UniProt ID Q15722
mRNA ID NM_181657
Length 352
RefSeq Status VALIDATED
Protein sequence is identical to GI:221218998 (mRNA isoform)

Gene Information

Entrez Gene ID
1241
Gene Name
leukotriene B4 receptor
Gene Symbol
LTB4R
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005887 TAS:ProtInc C integral component of plasma membrane
GO:0005886 TAS:Reactome C plasma membrane
GO:0001632 IEA:Ensembl F leukotriene B4 receptor activity
GO:0004974 TAS:ProtInc F leukotriene receptor activity
GO:0000166 TAS:ProtInc F nucleotide binding
GO:0006928 TAS:ProtInc P cellular component movement
GO:0007186 TAS:ProtInc P G-protein coupled receptor signaling pathway
GO:0006955 TAS:ProtInc P immune response
GO:0006954 TAS:ProtInc P inflammatory response
GO:0006936 TAS:ProtInc P muscle contraction
GO:0007200 TAS:ProtInc P phospholipase C-activating G-protein coupled receptor signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_18302 Leukotriene receptors

Domain Information

InterPro Annotations

Accession Description
IPR017452 GPCR, rhodopsin-like, 7TM
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR003981 Leukotriene B4 receptor
IPR003983 Leukotriene B4 type 1 receptor

UniProt Annotations

Entry Information

Gene Name
leukotriene B4 receptor
Protein Entry
LT4R1_HUMAN
UniProt ID
Q15722
Species
Human

Comments

Comment Type Description
Function Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
Ptm Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.
Sequence Caution Sequence=AAB16747.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the G-protein coupled receptor 1 family.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues.

Identical and Related Proteins

Unique RefSeq proteins for LMP002255 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
221218998 RefSeq NP_001137391 352 leukotriene B4 receptor 1

Identical Sequences to LMP002255 proteins

Reference Database Accession Length Protein Name
GI:221218998 DBBJ BAJ20610.1 352 leukotriene B4 receptor, partial [synthetic construct]
GI:221218998 GenBank AAP84348.1 352 leukotriene B4 receptor [Homo sapiens]
GI:221218998 GenBank EAW66029.1 352 leukotriene B4 receptor [Homo sapiens]
GI:221218998 GenBank ACC24508.1 352 Sequence 32 from patent US 7341840
GI:221218998 GenBank ADS48760.1 352 Sequence 32 from patent US 7803557
GI:221218998 RefSeq NP_858043.1 352 leukotriene B4 receptor 1 [Homo sapiens]

Related Sequences to LMP002255 proteins

Reference Database Accession Length Protein Name
GI:221218998 EMBL CAC42549.1 377 unnamed protein product [Homo sapiens]
GI:221218998 GenBank AAB16747.1 377 putative G-protein-coupled receptor [Homo sapiens]
GI:221218998 GenBank AAP35931.1 352 leukotriene B4 receptor [Homo sapiens]
GI:221218998 GenBank AAX32664.1 352 leukotriene B4 receptor [synthetic construct]
GI:221218998 GenBank ABW03628.1 352 leukotriene B4 receptor [synthetic construct]
GI:221218998 GenBank AIC61952.1 352 LTB4R, partial [synthetic construct]