Gene/Proteome Database (LMPD)
LMPD ID
LMP002268
Gene ID
Species
Homo sapiens (Human)
Gene Name
gamma-glutamyltransferase 5
Gene Symbol
Synonyms
GGL; GGT 5; GGT-REL; GGTLA1
Alternate Names
gamma-glutamyltransferase 5; glutathione hydrolase 5; leukotriene-C4 hydrolase; gamma-glutamyl cleaving enzyme; gamma-glutamyltranspeptidase 5; gamma-glutamyltransferase-like activity 1; gamma-glutamyl transpeptidase-related enzyme; gamma-glutamyl transpeptidase-related protein
Chromosome
22
Map Location
22q11.23
EC Number
2.3.2.2
Summary
This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and light subunit, with the catalytic activity contained within the small subunit. The encoded enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Orthologs
Proteins
| gamma-glutamyltransferase 5 isoform 1 | |
|---|---|
| Refseq ID | NP_001093251 |
| Protein GI | 153266901 |
| UniProt ID | P36269 |
| mRNA ID | NM_001099781 |
| Length | 587 |
| RefSeq Status | REVIEWED |
| MARGYGATVSLVLLGLGLALAVIVLAVVLSRHQAPCGPQAFAHAAVAADSKVCSDIGRAILQQQGSPVDATIAALVCTSVVNPQSMGLGGGVIFTIYNVTTGKVEVINARETVPASHAPSLLDQCAQALPLGTGAQWIGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAPVLSRFLHNSILRPSLQASTLRQLFFNGTEPLRPQDPLPWPALATTLETVATEGVEVFYTGRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVPLGDYTLYSPPPPAGGAILSFILNVLRGFNFSTESMARPEGRVNVYHHLVETLKFAKGQRWRLGDPRSHPKLQNASRDLLGETLAQLIRQQIDGRGDHQLSHYSLAEAWGHGTGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGIILNNELLDLCERCPRGSGTTPSPAVSGDRVGGAPGRCWPPVPGERSPSSMVPSILINKAQGSKLVIGGAGGELIISAVAQAIMSKLWLGFDLRAAIAAPILHVNSKGCVEYEPNFSQEVQRGLQDRGQNQTQRPFFLNVVQAVSQEGACVYAVSDLRKSGEAAGY | |
| gamma-glutamyltransferase 5 isoform 2 | |
|---|---|
| Refseq ID | NP_004112 |
| Protein GI | 153266885 |
| UniProt ID | P36269 |
| mRNA ID | NM_004121 |
| Length | 586 |
| RefSeq Status | REVIEWED |
| MARGYGATVSLVLLGLGLALAVIVLAVVLSRHQAPCGPQAFAHAAVAADSKVCSDIGRAILQQQGSPVDATIAALVCTSVVNPQSMGLGGGVIFTIYNVTTGKVEVINARETVPASHAPSLLDQCAQALPLGTGAQWIGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAPVLSRFLHNSILRPSLQASTLRQLFFNGTEPLRPQDPLPWPALATTLETVATEGVEVFYTGRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVPLGDYTLYSPPPPAGGAILSFILNVLRGFNFSTESMARPEGRVNVYHHLVETLKFAKGQRWRLGDPRSHPKLQNASRDLLGETLAQLIRQQIDGRGDHQLSHYSLAEAWGHGTGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGIILNNELLDLCERCPRGSGTTPSPVSGDRVGGAPGRCWPPVPGERSPSSMVPSILINKAQGSKLVIGGAGGELIISAVAQAIMSKLWLGFDLRAAIAAPILHVNSKGCVEYEPNFSQEVQRGLQDRGQNQTQRPFFLNVVQAVSQEGACVYAVSDLRKSGEAAGY | |
| mat_peptide: 1..387 product: Gamma-glutamyltransferase 5 heavy chain. {ECO:0000250} experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P36269.2) calculated_mol_wt: 41483 peptide sequence: MARGYGATVSLVLLGLGLALAVIVLAVVLSRHQAPCGPQAFAHAAVAADSKVCSDIGRAILQQQGSPVDATIAALVCTSVVNPQSMGLGGGVIFTIYNVTTGKVEVINARETVPASHAPSLLDQCAQALPLGTGAQWIGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAPVLSRFLHNSILRPSLQASTLRQLFFNGTEPLRPQDPLPWPALATTLETVATEGVEVFYTGRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVPLGDYTLYSPPPPAGGAILSFILNVLRGFNFSTESMARPEGRVNVYHHLVETLKFAKGQRWRLGDPRSHPKLQNASRDLLGETLAQLIRQQIDGRGDHQLSHYSLAEAWGHGTG mat_peptide: 1..387 product: Gamma-glutamyltransferase 5 heavy chain. {ECO:0000250} experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P36269.2) calculated_mol_wt: 41483 peptide sequence: MARGYGATVSLVLLGLGLALAVIVLAVVLSRHQAPCGPQAFAHAAVAADSKVCSDIGRAILQQQGSPVDATIAALVCTSVVNPQSMGLGGGVIFTIYNVTTGKVEVINARETVPASHAPSLLDQCAQALPLGTGAQWIGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAPVLSRFLHNSILRPSLQASTLRQLFFNGTEPLRPQDPLPWPALATTLETVATEGVEVFYTGRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVPLGDYTLYSPPPPAGGAILSFILNVLRGFNFSTESMARPEGRVNVYHHLVETLKFAKGQRWRLGDPRSHPKLQNASRDLLGETLAQLIRQQIDGRGDHQLSHYSLAEAWGHGTG mat_peptide: 388..586 product: Gamma-glutamyltransferase 5 light chain. {ECO:0000250} experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P36269.2) calculated_mol_wt: 20797 peptide sequence: TSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGIILNNELLDLCERCPRGSGTTPSPVSGDRVGGAPGRCWPPVPGERSPSSMVPSILINKAQGSKLVIGGAGGELIISAVAQAIMSKLWLGFDLRAAIAAPILHVNSKGCVEYEPNFSQEVQRGLQDRGQNQTQRPFFLNVVQAVSQEGACVYAVSDLRKSGEAAGY | |
| gamma-glutamyltransferase 5 isoform 3 | |
|---|---|
| Refseq ID | NP_001093252 |
| Protein GI | 153266901 |
| UniProt ID | P36269 |
| mRNA ID | NM_001099782 |
| Length | 587 |
| RefSeq Status | REVIEWED |
| MARGYGATVSLVLLGLGLALAVIVLAVVLSRHQAPCGPQAFAHAAVAADSKVCSDIGRAILQQQGSPVDATIAALVCTSVVNPQSMGLGGGVIFTIYNVTTGKVEVINARETVPASHAPSLLDQCAQALPLGTGAQWIGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAPVLSRFLHNSILRPSLQASTLRQLFFNGTEPLRPQDPLPWPALATTLETVATEGVEVFYTGRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVPLGDYTLYSPPPPAGGAILSFILNVLRGFNFSTESMARPEGRVNVYHHLVETLKFAKGQRWRLGDPRSHPKLQNASRDLLGETLAQLIRQQIDGRGDHQLSHYSLAEAWGHGTGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGIILNNELLDLCERCPRGSGTTPSPAVSGDRVGGAPGRCWPPVPGERSPSSMVPSILINKAQGSKLVIGGAGGELIISAVAQAIMSKLWLGFDLRAAIAAPILHVNSKGCVEYEPNFSQEVQRGLQDRGQNQTQRPFFLNVVQAVSQEGACVYAVSDLRKSGEAAGY | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0031362 | TAS:UniProtKB | C | anchored component of external side of plasma membrane |
| GO:0016021 | TAS:ProtInc | C | integral component of membrane |
| GO:0005886 | TAS:Reactome | C | plasma membrane |
| GO:0003840 | TAS:UniProtKB | F | gamma-glutamyltransferase activity |
| GO:0036374 | IEA:UniProtKB-EC | F | glutathione hydrolase activity |
| GO:0019369 | TAS:Reactome | P | arachidonic acid metabolic process |
| GO:0006520 | TAS:ProtInc | P | cellular amino acid metabolic process |
| GO:0006750 | IEA:UniProtKB-KW | P | glutathione biosynthetic process |
| GO:0006749 | TAS:UniProtKB | P | glutathione metabolic process |
| GO:0006954 | IEA:Ensembl | P | inflammatory response |
| GO:0019370 | ISS:UniProtKB | P | leukotriene biosynthetic process |
| GO:0006691 | TAS:Reactome | P | leukotriene metabolic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY66-375 | leukotriene biosynthesis |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_228214 | Aflatoxin activation and detoxification |
| REACT_6960 | Glutathione synthesis and recycling |
| REACT_150420 | Synthesis of Leukotrienes (LT) and Eoxins (EX) |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P36269-1; Sequence=Displayed; Name=2; IsoId=P36269-2; Sequence=VSP_008146; Note=No experimental confirmation available.; Name=3; IsoId=P36269-3; Sequence=VSP_043470; Note=No experimental confirmation available.; |
| Catalytic Activity | A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid. |
| Catalytic Activity | Glutathione + H(2)O = L-cysteinylglycine + L- glutamate. |
| Catalytic Activity | Leukotriene C(4) + H(2)O = leukotriene D(4) + L-glutamate. |
| Function | Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). |
| Pathway | Lipid metabolism; leukotriene D4 biosynthesis. |
| Pathway | Sulfur metabolism; glutathione metabolism. |
| Ptm | Cleaved by autocatalysis into a large and a small subunit. |
| Sequence Caution | Sequence=CAB55910.1; Type=Frameshift; Positions=446; Evidence= ; |
| Similarity | Belongs to the gamma-glutamyltransferase family. |
| Subcellular Location | Membrane ; Single-pass type II membrane protein . |
| Subunit | Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity). |
Identical and Related Proteins
Unique RefSeq proteins for LMP002268 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 153266901 | RefSeq | NP_001093251 | 587 | gamma-glutamyltransferase 5 isoform 1 |
| 153266885 | RefSeq | NP_004112 | 586 | gamma-glutamyltransferase 5 isoform 2 |
| 153266901 | RefSeq | NP_001093252 | 587 | gamma-glutamyltransferase 5 isoform 3 |
Identical Sequences to LMP002268 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:153266885 | DBBJ | BAF84695.1 | 586 | unnamed protein product [Homo sapiens] |
| GI:153266901 | GenBank | AAH73999.1 | 587 | Gamma-glutamyltransferase 5 [Homo sapiens] |
| GI:153266901 | GenBank | AAH73999.1 | 587 | Gamma-glutamyltransferase 5 [Homo sapiens] |
| GI:153266885 | GenBank | EAW59643.1 | 586 | gamma-glutamyltransferase-like activity 1, isoform CRA_a [Homo sapiens] |
| GI:153266885 | GenBank | ABM81961.1 | 586 | gamma-glutamyltransferase-like activity 1 [synthetic construct] |
| GI:153266885 | GenBank | ABM85140.1 | 586 | gamma-glutamyltransferase-like activity 1, partial [synthetic construct] |
| GI:153266885 | GenBank | ADA28832.1 | 586 | Sequence 15 from patent US 7611703 |
| GI:153266901 | GenBank | AIC48829.1 | 587 | GGT5, partial [synthetic construct] |
| GI:153266901 | GenBank | AIC48829.1 | 587 | GGT5, partial [synthetic construct] |
| GI:153266885 | SwissProt | P36269.2 | 586 | RecName: Full=Gamma-glutamyltransferase 5; Short=GGT 5; AltName: Full=Gamma-glutamyl transpeptidase-related enzyme; Short=GGT-rel; AltName: Full=Gamma-glutamyltransferase-like activity 1; AltName: Full=Gamma-glutamyltranspeptidase 5; AltName: Full=Glutathione hydrolase 5; AltName: Full=Leukotriene-C4 hydrolase; Contains: RecName: Full=Gamma-glutamyltransferase 5 heavy chain; Contains: RecName: Full=Gamma-glutamyltransferase 5 light chain; Flags: Precursor [Homo sapiens] |
Related Sequences to LMP002268 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:153266885 | GenBank | AAA58503.1 | 586 | gamma-glutmyl transpeptidase-related protein [Homo sapiens] |
| GI:153266901 | GenBank | AAH11362.1 | 586 | Gamma-glutamyltransferase 5 [Homo sapiens] |
| GI:153266901 | GenBank | AAH11362.1 | 586 | Gamma-glutamyltransferase 5 [Homo sapiens] |
| GI:153266901 | GenBank | AAP88810.1 | 586 | gamma-glutamyltransferase-like activity 1 [Homo sapiens] |
| GI:153266901 | GenBank | AAP88810.1 | 586 | gamma-glutamyltransferase-like activity 1 [Homo sapiens] |
| GI:153266885 | GenBank | AAH73999.1 | 587 | Gamma-glutamyltransferase 5 [Homo sapiens] |
| GI:153266901 | GenBank | AAX31953.1 | 586 | gamma-glutamyltransferase-like activity 1 [synthetic construct] |
| GI:153266901 | GenBank | AAX31953.1 | 586 | gamma-glutamyltransferase-like activity 1 [synthetic construct] |
| GI:153266901 | GenBank | AAX31954.1 | 586 | gamma-glutamyltransferase-like activity 1 [synthetic construct] |
| GI:153266901 | GenBank | AAX31954.1 | 586 | gamma-glutamyltransferase-like activity 1 [synthetic construct] |
| GI:153266901 | GenBank | ABM81961.1 | 586 | gamma-glutamyltransferase-like activity 1 [synthetic construct] |
| GI:153266901 | GenBank | ABM81961.1 | 586 | gamma-glutamyltransferase-like activity 1 [synthetic construct] |
| GI:153266901 | GenBank | ABM85140.1 | 586 | gamma-glutamyltransferase-like activity 1, partial [synthetic construct] |
| GI:153266901 | GenBank | ABM85140.1 | 586 | gamma-glutamyltransferase-like activity 1, partial [synthetic construct] |
| GI:153266885 | GenBank | ADA28833.1 | 586 | Sequence 16 from patent US 7611703 |
| GI:153266885 | GenBank | AIC48829.1 | 587 | GGT5, partial [synthetic construct] |
| GI:153266885 | RefSeq | NP_001093251.1 | 587 | gamma-glutamyltransferase 5 isoform 1 [Homo sapiens] |
| GI:153266885 | RefSeq | XP_009436235.1 | 586 | PREDICTED: gamma-glutamyltransferase 5 isoform X7 [Pan troglodytes] |