Gene/Proteome Database (LMPD)
Proteins
| tenascin-R precursor | |
|---|---|
| Refseq ID | NP_071707 |
| Protein GI | 226958549 |
| UniProt ID | Q8BYI9 |
| mRNA ID | NM_022312 |
| Length | 1358 |
| RefSeq Status | VALIDATED |
| MGIDGETVVLKNMLIGVNLILLGSMLKPSECRLEVTTERAQRQTVEEEGGASSYNTSSKEQPMVFNHVYNINVPLESLCSSGLEASAEQDMSAEDDTLAEYIGQTSDHESQVTFTHKINLPKKACPCASSSQVLQELLSRIEMLEREVSLLRDQCNTNCCQESAATGQLDYVPHCSGHGNFSFESCGCICNEGWFGKNCSEPYCPLGCSSRGVCVDGQCICDSEYSGDDCSELRCPTDCSSRGLCVDGECVCEEPYTGEDCRELRCPGDCSGKGQCANGTCLCQEGYAGEDCSQRRCLNACSGRGHCQEGLCICEEGYQGPDCSAVAPPEDLRVAGISDRSIELEWDGPMAVTEYVISYQPTALGGLQLQQRVPGDWSGVTIMELEPGLTYNISVYAVISNILSLPITAKVATHLSTPQGLQFKTITETTVEVQWEPFSFSFDGWEISFIPKNNEGGVIAQLPSDVTSFNQTGLKPGEEYIVNVVALKEQARSPPTSASVSTVIDGPTQILVRDVSDTVAFVEWTPPRAKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNESEASSTQFTTEIDAPKNLRVGSRTATSLDLEWDNSEAEAQEYKVVYSTLAGEQYHEVLVPKGIGPTTKTTLTDLVPGTEYGVGISAVMNSKQSIPATMNARTELDSPRDLMVTASSETSISLIWTKASGPIDHYRITFTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITAERGRQQSLESTVDAFTGFRPISHLHFSHVTSSSVNITWSDPSPPADRLILNYSPRDKEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTVTSEPIVGSITTGIDPPKNITISNVTKDSLTVSWSSPVAPFDYYRVSYRPTQVGRLDSSVVPNTVTEFAITRLYPATEYEISLNSVRGREESERICTLVHTAMDSPMDLIATNITPTEALLQWKAPMGEVENYVIVLTHFAIAGETILVDGVSEEFQLVDLLPSTHYTVTMYATSGPLMSGTIATNFSTLLDPPDNLTASEVTRQSALISWQPPRAAIENYVLTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYTVLLQAAQEATRSSLTSTVFTTGGRVFSHPQDCAQHLMNGDTLSGVYTIFLNGELSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLDNIHRITAQGRYELRVDMRDGQEAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAMSYKGAWWYKNCHRTNLNGKYGESRHSQGINWYHWKGHEFSIPFVEMKMRPYIHRLTAGRKRRALKF | |
| sig_peptide: 1..31 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q8BYI9.2) calculated_mol_wt: 3289 peptide sequence: MGIDGETVVLKNMLIGVNLILLGSMLKPSEC mat_peptide: 32..1358 product: Tenascin-R experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8BYI9.2) calculated_mol_wt: 146319 peptide sequence: RLEVTTERAQRQTVEEEGGASSYNTSSKEQPMVFNHVYNINVPLESLCSSGLEASAEQDMSAEDDTLAEYIGQTSDHESQVTFTHKINLPKKACPCASSSQVLQELLSRIEMLEREVSLLRDQCNTNCCQESAATGQLDYVPHCSGHGNFSFESCGCICNEGWFGKNCSEPYCPLGCSSRGVCVDGQCICDSEYSGDDCSELRCPTDCSSRGLCVDGECVCEEPYTGEDCRELRCPGDCSGKGQCANGTCLCQEGYAGEDCSQRRCLNACSGRGHCQEGLCICEEGYQGPDCSAVAPPEDLRVAGISDRSIELEWDGPMAVTEYVISYQPTALGGLQLQQRVPGDWSGVTIMELEPGLTYNISVYAVISNILSLPITAKVATHLSTPQGLQFKTITETTVEVQWEPFSFSFDGWEISFIPKNNEGGVIAQLPSDVTSFNQTGLKPGEEYIVNVVALKEQARSPPTSASVSTVIDGPTQILVRDVSDTVAFVEWTPPRAKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNESEASSTQFTTEIDAPKNLRVGSRTATSLDLEWDNSEAEAQEYKVVYSTLAGEQYHEVLVPKGIGPTTKTTLTDLVPGTEYGVGISAVMNSKQSIPATMNARTELDSPRDLMVTASSETSISLIWTKASGPIDHYRITFTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITAERGRQQSLESTVDAFTGFRPISHLHFSHVTSSSVNITWSDPSPPADRLILNYSPRDKEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTVTSEPIVGSITTGIDPPKNITISNVTKDSLTVSWSSPVAPFDYYRVSYRPTQVGRLDSSVVPNTVTEFAITRLYPATEYEISLNSVRGREESERICTLVHTAMDSPMDLIATNITPTEALLQWKAPMGEVENYVIVLTHFAIAGETILVDGVSEEFQLVDLLPSTHYTVTMYATSGPLMSGTIATNFSTLLDPPDNLTASEVTRQSALISWQPPRAAIENYVLTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYTVLLQAAQEATRSSLTSTVFTTGGRVFSHPQDCAQHLMNGDTLSGVYTIFLNGELSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLDNIHRITAQGRYELRVDMRDGQEAVFAYYDKFAVEDSRSLYKIRIGSYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAMSYKGAWWYKNCHRTNLNGKYGESRHSQGINWYHWKGHEFSIPFVEMKMRPYIHRLTAGRKRRALKF | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0009986 | IDA:MGI | C | cell surface |
| GO:0005737 | IEA:Ensembl | C | cytoplasm |
| GO:0045121 | IDA:MGI | C | membrane raft |
| GO:0005634 | IEA:Ensembl | C | nucleus |
| GO:0072534 | IDA:MGI | C | perineuronal net |
| GO:0005578 | IDA:MGI | C | proteinaceous extracellular matrix |
| GO:0046625 | TAS:MGI | F | sphingolipid binding |
| GO:0008306 | IMP:MGI | P | associative learning |
| GO:0030198 | IMP:MGI | P | extracellular matrix organization |
| GO:0035641 | IMP:MGI | P | locomotory exploration behavior |
| GO:0060291 | IMP:MGI | P | long-term synaptic potentiation |
| GO:0030517 | IDA:MGI | P | negative regulation of axon extension |
| GO:0048692 | IMP:MGI | P | negative regulation of axon extension involved in regeneration |
| GO:0022408 | IDA:MGI | P | negative regulation of cell-cell adhesion |
| GO:0010977 | IDA:MGI | P | negative regulation of neuron projection development |
| GO:0050805 | IMP:MGI | P | negative regulation of synaptic transmission |
| GO:0050885 | IMP:MGI | P | neuromuscular process controlling balance |
| GO:0007158 | IMP:MGI | P | neuron cell-cell adhesion |
| GO:0051968 | IMP:MGI | P | positive regulation of synaptic transmission, glutamatergic |
| GO:0051971 | IMP:MGI | P | positive regulation of transmission of nerve impulse |
| GO:0050804 | IMP:MGI | P | regulation of synaptic transmission |
| GO:0050808 | IMP:MGI | P | synapse organization |
| GO:0022029 | IMP:MGI | P | telencephalon cell migration |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR013111 | EGF-like domain, extracellular |
| IPR013032 | EGF-like, conserved site |
| IPR000742 | Epidermal growth factor-like domain |
| IPR002181 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain |
| IPR014716 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 |
| IPR014715 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2 |
| IPR003961 | Fibronectin type III |
| IPR013783 | Immunoglobulin-like fold |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=J1-180, TN-R 180; IsoId=Q8BYI9-1; Sequence=Displayed; Name=2; Synonyms=J1-160, TN-R 160; IsoId=Q8BYI9-2; Sequence=VSP_012994; |
| Developmental Stage | Isoform 1 is barely detectable at E17 embryo and increases in intensity until postnatal day 15, when it reaches adult levels. Isoform 2 is detectable from postnatal day 5 and reaches adult levels also at postnatal day 15. {ECO:0000269|PubMed:2477380}. |
| Domain | The EGF-like domains mediate interaction with CNTN1. The fibronectin type-III domains 3-5 mediate interaction with BCAN. The fibronectin type-III domains 1-2 and 7-9 mediate interaction with SCN2B (By similarity). {ECO:0000250}. |
| Function | Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Theses interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediates inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity). {ECO:0000250}. |
| Miscellaneous | Knockout mice display alterations of the extracellular matrix, and decreased axonal conduction velocities in the CNS. |
| Ptm | Contains N-linked oligosaccharides with a sulfated carbohydrate structures (By similarity). Contains N-linked oligosaccharides, O-linked sialylated structures and O-linked chondroitin sulfate glycosaminoglycans. {ECO:0000250, ECO:0000269|PubMed:10406848, ECO:0000269|PubMed:10773191}. |
| Similarity | Belongs to the tenascin family. {ECO:0000305}. |
| Similarity | Contains 1 fibrinogen C-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00739}. |
| Similarity | Contains 5 EGF-like domains. {ECO:0000305}. |
| Similarity | Contains 9 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}. |
| Subcellular Location | Secreted, extracellular space, extracellular matrix. |
| Subunit | Interacts with BCAN and ACAN in a calcium-dependent manner. Interacts with SCN2B, PTPRZ1, and CSPG3 (By similarity). Forms oligomers. Isoforms 1 and 2 form respectively trimeric (tribrachion) and dimeric kink-armed rodlike structures, which are linked by disulfide bridges. Interacts with CNTN1, TNC and FN1. {ECO:0000250, ECO:0000269|PubMed:10773191, ECO:0000269|PubMed:7678967}. |
| Tissue Specificity | Brain-specific. {ECO:0000269|PubMed:2477380}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002276 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 226958549 | RefSeq | NP_071707 | 1358 | tenascin-R precursor |
Identical Sequences to LMP002276 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:226958549 | GenBank | AAI32393.1 | 1358 | Tenascin R [Mus musculus] |
| GI:226958549 | GenBank | AAI38044.1 | 1358 | Tenascin R [Mus musculus] |
| GI:226958549 | RefSeq | XP_006496805.1 | 1358 | PREDICTED: tenascin-R isoform X1 [Mus musculus] |
| GI:226958549 | RefSeq | XP_006496806.1 | 1358 | PREDICTED: tenascin-R isoform X2 [Mus musculus] |
| GI:226958549 | RefSeq | XP_006496807.1 | 1358 | PREDICTED: tenascin-R isoform X3 [Mus musculus] |
| GI:226958549 | SwissProt | Q8BYI9.2 | 1358 | RecName: Full=Tenascin-R; Short=TN-R; AltName: Full=Janusin; AltName: Full=Neural recognition molecule J1-160/180; AltName: Full=Restrictin; Flags: Precursor [Mus musculus] |
Related Sequences to LMP002276 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:226958549 | DBBJ | BAC30335.1 | 1358 | unnamed protein product [Mus musculus] |
| GI:226958549 | GenBank | EDM09448.1 | 1358 | tenascin R, isoform CRA_b [Rattus norvegicus] |
| GI:226958549 | GenBank | EGV93302.1 | 1358 | Tenascin-R [Cricetulus griseus] |
| GI:226958549 | RefSeq | XP_003497724.1 | 1358 | PREDICTED: tenascin-R [Cricetulus griseus] |
| GI:226958549 | RefSeq | XP_005363992.1 | 1358 | PREDICTED: tenascin-R [Microtus ochrogaster] |
| GI:226958549 | RefSeq | XP_007610858.1 | 1358 | PREDICTED: tenascin-R [Cricetulus griseus] |