Gene/Proteome Database (LMPD)
LMPD ID
LMP002289
Gene ID
Species
Homo sapiens (Human)
Gene Name
nuclear receptor coactivator 6
Gene Symbol
Synonyms
AIB3; ASC2; NRC; PRIP; RAP250; TRBP
Chromosome
20
Map Location
20q11
Summary
The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]
Orthologs
Proteins
| nuclear receptor coactivator 6 isoform 1 | |
|---|---|
| Refseq ID | NP_054790 |
| Protein GI | 32307128 |
| UniProt ID | Q14686 |
| mRNA ID | NM_014071 |
| Length | 2063 |
| RefSeq Status | REVIEWED |
| MVLDDLPNLEDIYTSLCSSTMEDSEMDFDSGLEDDDTKSDSILEDSTIFVAFKGNIDDKDFKWKLDAILKNVPNLLHMESSKLKVQKVEPWNSVRVTFNIPREAAERLRILAQSNNQQLRDLGILSVQIEGEGAINLALAQNRSQDVRMNGPMGAGNSVRMEAGFPMASGPGIIRMNNPATVMIPPGGNVSSSMMAPGPNPELQPRTPRPASQSDAMDPLLSGLHIQQQSHPSGSLAPPHHPMQPVSVNRQMNPANFPQLQQQQQQQQQQQQQQQQQQQQQQQQQLQARPPQQHQQQQPQGIRPQFTAPTQVPVPPGWNQLPSGALQPPPAQGSLGTMTANQGWKKAPLPGPMQQQLQARPSLATVQTPSHPPPPYPFGSQQASQAHTNFPQMSNPGQFTAPQMKSLQGGPSRVPTPLQQPHLTNKSPASSPSSFQQGSPASSPTVNQTQQQMGPRPPQNNPLPQGFQQPVSSPGRNPMVQQGNVPPNFMVMQQQPPNQGPQSLHPGLGGMPKRLPPGFSAGQANPNFMQGQVPSTTATTPGNSGAPQLQANQNVQHAGGQGAGPPQNQMQVSHGPPNMMQPSLMGIHGNMNNQQAGTSGVPQVNLSNMQGQPQQGPPSQLMGMHQQIVPSQGQMVQQQGTLNPQNPMILSRAQLMPQGQMMVNPPSQNLGPSPQRMTPPKQMLSQQGPQMMAPHNQMMGPQGQVLLQQNPMIEQIMTNQMQGNKQQFNTQNQSNVMPGPAQIMRGPTPNMQGNMVQFTGQMSGQMLPQQGPVNNSPSQVMGIQGQVLRPPGPSPHMAQQHGDPATTANNDVSLSQMMPDVSIQQTNMVPPHVQAMQGNSASGNHFSGHGMSFNAPFSGAPNGNQMSCGQNPGFPVNKDVTLTSPLLVNLLQSDISAGHFGVNNKQNNTNANKPKKKKPPRKKKNSQQDLNTPDTRPAGLEEADQPPLPGEQGINLDNSGPKLPEFSNRPPGYPSQPVEQRPLQQMPPQLMQHVAPPPQPPQQQPQPQLPQQQQPPPPSQPQSQQQQQQQQQMMMMLMMQQDPKSVRLPVSQNVHPPRGPLNPDSQRMPMQQSGSVPVMVSLQGPASVPPSPDKQRMPMPVNTPLGSNSRKMVYQESPQNPSSSPLAEMASLPEASGSEAPSVPGGPNNMPSHVVLPQNQLMMTGPKPGPSPLSATQGATPQQPPVNSLPSSHGHHFPNVAAPTQTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLNASIAGLFPPQINIPLPPRPNLNRGFDQQGLNPTTLKAIGQAPSNLTMNPSNFATPQTHKLDSVVVNSGKQSNSGATKRASPSNSRRSSPGSSRKTTPSPGRQNSKAPKLTLASQTNAALLQNVELPRNVLVSPTPLANPPVPGSFPNNSGLNPQNSTVSVAAVGGVVEDNKESLNVPQDSDCQNSQSRKEQVNIELKAVPAQEVKMVVPEDQSKKDGQPSDPNKLPSVEENKNLVSPAMREAPTSLSQLLDNSGAPNVTIKPPGLTDLEVTPPVVSGEDLKKASVIPTLQDLSSSKEPSNSLNLPHSNELCSSLVHPELSEVSSNVAPSIPPVMSRPVSSSSISTPLPPNQITVFVTSNPITTSANTSAALPTHLQSALMSTVVTMPNAGSKVMVSEGQSAAQSNARPQFITPVFINSSSIIQVMKGSQPSTIPAAPLTTNSGLMPPSVAVVGPLHIPQNIKFSSAPVPPNALSSSPAPNIQTGRPLVLSSRATPVQLPSPPCTSSPVVPSHPPVQQVKELNPDEASPQVNTSADQNTLPSSQSTTMVSPLLTNSPGSSGNRRSPVSSSKGKGKVDKIGQILLTKACKKVTGSLEKGEEQYGADGETEGQGLDTTAPGLMGTEQLSTELDSKTPTPPAPTLLKMTSSPVGPGTASAGPSLPGGALPTSVRSIVTTLVPSELISAVPTTKSNHGGIASESLAGGLVEEKVGSHPELLPSIAPSQNLVSKETSTTALQASVARPELEVNAAIVSGQSSEPKEIVEKSKIPGRRNSRTEEPTVASESVENGHRKRSSRPASASSSTKDITSAVQSKRRKSK | |
| nuclear receptor coactivator 6 isoform 2 | |
|---|---|
| Refseq ID | NP_001229468 |
| Protein GI | 335892792 |
| UniProt ID | Q14686 |
| mRNA ID | NM_001242539 |
| Length | 1070 |
| RefSeq Status | REVIEWED |
| MVLDDLPNLEDIYTSLCSSTMEDSEMDFDSGLEDDDTKSDSILEDSTIFVAFKGNIDDKDFKWKLDAILKNVPNLLHMESSKLKVQKVEPWNSVRVTFNIPREAAERLRILAQSNNQQLRDLGILSVQIEGEGAINLALAQNRSQDVRMNGPMGAGNSVRMEAGFPMASGPGIIRMNNPATVMIPPGGNVSSSMMAPGPNPELQPRTPRPASQSDAMDPLLSGLHIQQQSHPSGSLAPPHHPMQPVSVNRQMNPANFPQLQQQQQQQQQQQQQQQQQQQQQQQQQLQARPPQQHQQQQPQGIRPQFTAPTQVPVPPGWNQLPSGALQPPPAQGSLGTMTANQGWKKAPLPGPMQQQLQARPSLATVQTPSHPPPPYPFGSQQASQAHTNFPQMSNPGQFTAPQMKSLQGGPSRVPTPLQQPHLTNKSPASSPSSFQQGSPASSPTVNQTQQQMGPRPPQNNPLPQGFQQPVSSPGRNPMVQQGNVPPNFMVMQQQPPNQGPQSLHPGLGGMPKRLPPGFSAGQANPNFMQGQVPSTTATTPGNSGAPQLQANQNVQHAGGQGAGPPQNQMQVSHGPPNMMQPSLMGIHGNMNNQQAGTSGVPQVNLSNMQGQPQQGPPSQLMGMHQQIVPSQGQMVQQQGTLNPQNPMILSRAQLMPQGQMMVNPPSQNLGPSPQRMTPPKQMLSQQGPQMMAPHNQMMGPQGQVLLQQNPMIEQIMTNQMQGNKQQFNTQNQSNVMPGPAQIMRGPTPNMQGNMVQFTGQMSGQMLPQQGPVNNSPSQVMGIQGQVLRPPGPSPHMAQQHGDPATTANNDVSLSQMMPDVSIQQTNMVPPHVQAMQGNSASGNHFSGHGMSFNAPFSGAPNGNQMSCGQNPGFPVNKDVTLTSPLLVNLLQSDISAGHFGVNNKQNNTNANKPKKKKPPRKKKNSQQDLNTPDTRPAGLEEADQPPLPGEQGINLDNSGPKLPEFSNRPPAPSQNLVSKETSTTALQASVARPELEVNAAIVSGQSSEPKEIVEKSKIPGRRNSRTEEPTVASESVENGHRKRSSRPASASSSTKDITSAVQSKRRKSK | |
Gene Information
Entrez Gene ID
Gene Name
nuclear receptor coactivator 6
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0035097 | IDA:MGI | C | histone methyltransferase complex |
| GO:0043231 | IDA:HPA | C | intracellular membrane-bounded organelle |
| GO:0005654 | TAS:Reactome | C | nucleoplasm |
| GO:0005634 | IDA:UniProtKB | C | nucleus |
| GO:0005667 | TAS:UniProtKB | C | transcription factor complex |
| GO:0003682 | ISS:UniProtKB | F | chromatin binding |
| GO:0019899 | IPI:UniProtKB | F | enzyme binding |
| GO:0030331 | TAS:UniProtKB | F | estrogen receptor binding |
| GO:0030374 | IPI:UniProtKB | F | ligand-dependent nuclear receptor transcription coactivator activity |
| GO:0046965 | TAS:UniProtKB | F | retinoid X receptor binding |
| GO:0046966 | IDA:UniProtKB | F | thyroid hormone receptor binding |
| GO:0003713 | IDA:UniProtKB | F | transcription coactivator activity |
| GO:0006310 | NAS:UniProtKB | P | DNA recombination |
| GO:0006281 | NAS:UniProtKB | P | DNA repair |
| GO:0006260 | NAS:UniProtKB | P | DNA replication |
| GO:0006352 | IDA:UniProtKB | P | DNA-templated transcription, initiation |
| GO:0007420 | ISS:UniProtKB | P | brain development |
| GO:0044255 | TAS:Reactome | P | cellular lipid metabolic process |
| GO:0006974 | IDA:MGI | P | cellular response to DNA damage stimulus |
| GO:0042921 | NAS:UniProtKB | P | glucocorticoid receptor signaling pathway |
| GO:0007507 | ISS:UniProtKB | P | heart development |
| GO:0030520 | NAS:UniProtKB | P | intracellular estrogen receptor signaling pathway |
| GO:0060716 | IEA:Ensembl | P | labyrinthine layer blood vessel development |
| GO:0030099 | IDA:UniProtKB | P | myeloid cell differentiation |
| GO:0045944 | IDA:UniProtKB | P | positive regulation of transcription from RNA polymerase II promoter |
| GO:0045893 | TAS:UniProtKB | P | positive regulation of transcription, DNA-templated |
| GO:0009725 | TAS:UniProtKB | P | response to hormone |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0006367 | ISS:UniProtKB | P | transcription initiation from RNA polymerase II promoter |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_147904 | Activation of gene expression by SREBF (SREBP) |
| REACT_118659 | RORA activates circadian gene expression |
| REACT_200608 | Transcriptional activation of mitochondrial biogenesis |
| REACT_118713 | YAP1- and WWTR1 (TAZ)-stimulated gene expression |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR026638 | Nuclear receptor coactivator 6 |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Domain | Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Only motif 1 is essential for the association with nuclear receptors, while adjacent Ser-884 displays selectivity for nuclear receptors. |
| Function | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. |
| Interaction | P10275:AR; NbExp=2; IntAct=EBI-78670, EBI-608057; Q9UBL3:ASH2L; NbExp=7; IntAct=EBI-78670, EBI-540797; Q92793:CREBBP; NbExp=2; IntAct=EBI-78670, EBI-81215; Q8NEZ4:KMT2C; NbExp=5; IntAct=EBI-78670, EBI-1042997; O14686:KMT2D; NbExp=6; IntAct=EBI-78670, EBI-996065; P06400:RB1; NbExp=3; IntAct=EBI-78670, EBI-491274; P61964:WDR5; NbExp=2; IntAct=EBI-78670, EBI-540834; |
| Miscellaneous | Frequently amplified or overexpressed in colon, breast and lung cancers. |
| Ptm | Phosphorylated by PRKDC. |
| Ptm | Phosphorylation on Ser-884 leads to a strong decrease in binding to ESR1 and ESR2. {ECO |
| Sequence Caution | Sequence=AAF16403.1; Type=Frameshift; Positions=88; Evidence= ; Sequence=BAA11498.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; |
| Subcellular Location | Nucleus. |
| Subunit | Monomer and homodimer. Interacts with RBM39 (By similarity). Interacts in vitro with the basal transcription factors GTF2A and TBP, suggesting an autonomous transactivation function. Interacts with NCOA1, CRSP3, RBM14, the histone acetyltransferases EP300 and CREBBP, and with the methyltransferases NCOA6IP and PRMT2/HRMT1L1. Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin. Interacts with ZNF335; may enhance ligand-dependent transcriptional activation by nuclear hormone receptors. {ECO |
| Tissue Specificity | Ubiquitous. Highly expressed in brain, prostate, testis and ovary; weakly expressed in lung, thymus and small intestine. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002289 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 32307128 | RefSeq | NP_054790 | 2063 | nuclear receptor coactivator 6 isoform 1 |
| 335892792 | RefSeq | NP_001229468 | 1070 | nuclear receptor coactivator 6 isoform 2 |
Identical Sequences to LMP002289 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:32307128 | GenBank | EAW76254.1 | 2063 | nuclear receptor coactivator 6, isoform CRA_a [Homo sapiens] |
| GI:32307128 | GenBank | EAW76255.1 | 2063 | nuclear receptor coactivator 6, isoform CRA_a [Homo sapiens] |
| GI:32307128 | GenBank | AAI36273.1 | 2063 | Nuclear receptor coactivator 6 [Homo sapiens] |
| GI:335892792 | GenBank | AEG79564.1 | 1070 | nuclear receptor coactivator-6 beta [Homo sapiens] |
| GI:32307128 | RefSeq | XP_005260405.1 | 2063 | PREDICTED: nuclear receptor coactivator 6 isoform X3 [Homo sapiens] |
| GI:32307128 | SwissProt | Q14686.3 | 2063 | RecName: Full=Nuclear receptor coactivator 6; AltName: Full=Activating signal cointegrator 2; Short=ASC-2; AltName: Full=Amplified in breast cancer protein 3; AltName: Full=Cancer-amplified transcriptional coactivator ASC-2; AltName: Full=Nuclear receptor coactivator RAP250; Short=NRC RAP250; AltName: Full=Nuclear receptor-activating protein, 250 kDa; AltName: Full=Peroxisome proliferator-activated receptor-interacting protein; Short=PPAR-interacting protein; Short=PRIP; AltName: Full=Thyroid hormone receptor-binding protein [Homo sapiens] |
Related Sequences to LMP002289 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:32307128 | DBBJ | BAA11498.2 | 2079 | KIAA0181, partial [Homo sapiens] |
| GI:32307128 | DBBJ | BAG09642.1 | 2063 | nuclear receptor coactivator 6, partial [synthetic construct] |
| GI:32307128 | GenBank | AAF13595.1 | 2063 | cancer-amplified transcriptional coactivator ASC-2 [Homo sapiens] |
| GI:32307128 | GenBank | AAF37003.1 | 2063 | nuclear receptor coactivator RAP250 [Homo sapiens] |
| GI:32307128 | GenBank | AAF71829.1 | 2063 | thyroid hormone receptor binding protein [Homo sapiens] |
| GI:32307128 | GenBank | AAF78480.1 | 2063 | nuclear receptor coactivator [Homo sapiens] |
| GI:335892792 | RefSeq | XP_004090170.1 | 1080 | PREDICTED: nuclear receptor coactivator 6 [Nomascus leucogenys] |
| GI:335892792 | RefSeq | XP_005568845.1 | 1071 | PREDICTED: nuclear receptor coactivator 6 isoform X3 [Macaca fascicularis] |
| GI:335892792 | RefSeq | XP_006144098.1 | 1077 | PREDICTED: nuclear receptor coactivator 6 isoform X6 [Tupaia chinensis] |
| GI:335892792 | RefSeq | XP_008955461.1 | 1077 | PREDICTED: nuclear receptor coactivator 6 isoform X5 [Pan paniscus] |
| GI:335892792 | RefSeq | XP_009214535.1 | 1077 | PREDICTED: nuclear receptor coactivator 6 isoform X9 [Papio anubis] |
| GI:335892792 | RefSeq | XP_009214536.1 | 1068 | PREDICTED: nuclear receptor coactivator 6 isoform X10 [Papio anubis] |