Gene/Proteome Database (LMPD)

LMPD ID
LMP002294
Gene ID
56050
Species
Mus musculus (Mouse)
Gene Name
cytochrome P450, family 39, subfamily a, polypeptide 1
Gene Symbol
Cyp39a1
Synonyms
mCYP39A1
Chromosome
17
Map Location
17 B3|17

Proteins

24-hydroxycholesterol 7-alpha-hydroxylase isoform 1
Refseq ID NP_061375
Protein GI 9256529
UniProt ID Q544S6
mRNA ID NM_018887
Length 470
RefSeq Status VALIDATED
MGIMELFSPIAIAVLGSCVLFLFSRLKNLLGPPCIQGWIPWIGAGLEFGKAPLEFIEKARIKYGPVFTIFAMGNRMTFVSEEEGINVLLKSEHVDFESAVQSPVYHTAWIPKNVFSALHERLYALMKGKMGTFNTHHFTGPLTEELHEQLEGLGTHGTMDLNDFVRYLLYPATLNTLFKKGLFLTDKRTIKEFYQQFKTYDEGFEYGSQLPEWLLRNWSKSKRWLLALFEKNIGNIKAHGSAGHSGTLLQAILEVVETETRQYSPNYGLVVLWAALANAPPIAFWTLGYILSHPDIHRTVLESISSVFGTAGKDKIKVSEDDLKKLLIIKWCILESVRLRAPGVITRKVVKPVKILNHTVPSGDLLMLSPFWLHRNPKYFPEPESFKPERWKEANLDKYIFLDYFMAFGGGKFQCPGRWFALLEIQLCIILVLYKYECSLLDPLPKQSSRHLVGVPQPAGKCRIEYKQRA
24-hydroxycholesterol 7-alpha-hydroxylase isoform 2
Refseq ID NP_001272876
Protein GI 552953854
UniProt ID Q544S6
mRNA ID NM_001285947
Length 420
RefSeq Status VALIDATED
MGIMELFSPIAIAVLGSCVLFLFSRLKNLLGPPCIQGWIPWIGAGLEFGKAPLEFIEKARIKYGPVFTIFAMGNRMTFVSEEEGINVLLKSEHVDFESAVQSPVYHTAWIPKNVFSALHERLYALMKGKMGTFNTHHFTGPLTEELHEQLEGLGTHGTMDLNDFVRNWSKSKRWLLALFEKNIGNIKAHGSAGHSGTLLQAILEVVETETRQYSPNYGLVVLWAALANAPPIAFWTLGYILSHPDIHRTVLESISSVFGTAGKDKIKVSEDDLKKLLIIKWCILESVRLRAPGVITRKVVKPVKILNHTVPSGDLLMLSPFWLHRNPKYFPEPESFKPERWKEANLDKYIFLDYFMAFGGGKFQCPGRWFALLEIQLCIILVLYKYECSLLDPLPKQSSRHLVGVPQPAGKCRIEYKQRA
24-hydroxycholesterol 7-alpha-hydroxylase isoform 3
Refseq ID NP_001272877
Protein GI 552953856
UniProt ID Q544S6
mRNA ID NM_001285948
Length 404
RefSeq Status VALIDATED
MGIMELFSPIAIAVLGSCVLFLFSRLKNLLGPPCIQGWIPWIGAGLEFGKAPLEFIEKARIKYGPVFTIFAMGNRMTFVSEEEGINVLLKSEHVDFESAVQSPVYHTAWIPKNVFSALHERLYALMKGKMGTFNTHHFTGPLTEELHEQLEGLGTHGTMDLNDFVRYLLYPATLNTLFKKGLFLTDKRTIKEFYQQFKTYDEGFEYGSQLPEWLLRNWSKSKRWLLALFEKNIGNIKAHGSAGHSGTLLQAILEVVETETRQYSPNYGLVVLWAALANAPPIAFWTLGYILSHPDIHRTVLESISSVFGTAGKDKIKVSEDDLKKLLIIKWCILESVRLRAPGVITRKVVKPVKILNHTVPSGDLLMLSPFWLHRNPKYFPEPESFKPVVCSLRDSTMHYLSAV

Gene Information

Entrez Gene ID
56050
Gene Name
cytochrome P450, family 39, subfamily a, polypeptide 1
Gene Symbol
Cyp39a1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IEA:UniProtKB-SubCell C endoplasmic reticulum membrane
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0008396 IEA:Ensembl F oxysterol 7-alpha-hydroxylase activity
GO:0008387 IDA:MGI F steroid 7-alpha-hydroxylase activity
GO:0006699 IEA:Ensembl P bile acid biosynthetic process
GO:0006707 IDA:MGI P cholesterol catabolic process

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002403 Cytochrome P450, E-class, group IV
IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-type

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 39, subfamily a, polypeptide 1
Protein Entry
Q544S6_MOUSE
UniProt ID
Q544S6
Species
Mouse

Comments

Comment Type Description
Cofactor Note=Heme group. {ECO:0000256|PIRNR:PIRNR000047, ECO:0000256|PIRSR:PIRSR000047-1};
Similarity Belongs to the cytochrome P450 family.
Subcellular Location Endoplasmic reticulum membrane .

Identical and Related Proteins

Unique RefSeq proteins for LMP002294 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
9256529 RefSeq NP_061375 470 24-hydroxycholesterol 7-alpha-hydroxylase isoform 1
552953854 RefSeq NP_001272876 420 24-hydroxycholesterol 7-alpha-hydroxylase isoform 2
552953856 RefSeq NP_001272877 404 24-hydroxycholesterol 7-alpha-hydroxylase isoform 3

Identical Sequences to LMP002294 proteins

Reference Database Accession Length Protein Name
GI:9256529 DBBJ BAC27530.1 470 unnamed protein product [Mus musculus]
GI:9256529 GenBank AAF63328.1 470 oxysterol 7alpha-hydroxylase [Mus musculus]
GI:552953854 GenBank EDL23411.1 420 cytochrome P450, family 39, subfamily a, polypeptide 1, isoform CRA_a [Mus musculus]
GI:9256529 GenBank EDL23413.1 470 cytochrome P450, family 39, subfamily a, polypeptide 1, isoform CRA_c [Mus musculus]
GI:9256529 SwissProt Q9JKJ9.1 470 RecName: Full=24-hydroxycholesterol 7-alpha-hydroxylase; AltName: Full=Cytochrome P450 39A1; Short=mCYP39A1; AltName: Full=Oxysterol 7-alpha-hydroxylase [Mus musculus]

Related Sequences to LMP002294 proteins

Reference Database Accession Length Protein Name
GI:552953856 DBBJ BAC27530.1 470 unnamed protein product [Mus musculus]
GI:552953854 DBBJ BAC27530.1 470 unnamed protein product [Mus musculus]
GI:552953854 GenBank AAF63328.1 470 oxysterol 7alpha-hydroxylase [Mus musculus]
GI:552953854 GenBank AAH37663.1 420 Cyp39a1 protein [Mus musculus]
GI:552953856 GenBank AAH21418.1 404 Cyp39a1 protein [Mus musculus]
GI:552953856 GenBank EDL23412.1 407 cytochrome P450, family 39, subfamily a, polypeptide 1, isoform CRA_b, partial [Mus musculus]
GI:552953854 GenBank EDL23413.1 470 cytochrome P450, family 39, subfamily a, polypeptide 1, isoform CRA_c [Mus musculus]
GI:552953856 GenBank EDL23413.1 470 cytochrome P450, family 39, subfamily a, polypeptide 1, isoform CRA_c [Mus musculus]
GI:9256529 GenBank EDM18705.1 465 cytochrome P450, family 39, subfamily a, polypeptide 1 (predicted), isoform CRA_a [Rattus norvegicus]
GI:552953854 RefSeq NP_061375.1 470 24-hydroxycholesterol 7-alpha-hydroxylase isoform 1 [Mus musculus]
GI:552953856 RefSeq NP_061375.1 470 24-hydroxycholesterol 7-alpha-hydroxylase isoform 1 [Mus musculus]
GI:9256529 RefSeq NP_001100363.1 465 24-hydroxycholesterol 7-alpha-hydroxylase [Rattus norvegicus]
GI:9256529 RefSeq XP_006244666.1 482 PREDICTED: 24-hydroxycholesterol 7-alpha-hydroxylase isoform X3 [Rattus norvegicus]
GI:9256529 RefSeq XP_006244667.1 470 PREDICTED: 24-hydroxycholesterol 7-alpha-hydroxylase isoform X4 [Rattus norvegicus]
GI:9256529 RefSeq XP_008765076.1 495 PREDICTED: 24-hydroxycholesterol 7-alpha-hydroxylase isoform X1 [Rattus norvegicus]
GI:9256529 RefSeq XP_008765077.1 483 PREDICTED: 24-hydroxycholesterol 7-alpha-hydroxylase isoform X2 [Rattus norvegicus]
GI:552953854 SwissProt Q9JKJ9.1 470 RecName: Full=24-hydroxycholesterol 7-alpha-hydroxylase; AltName: Full=Cytochrome P450 39A1; Short=mCYP39A1; AltName: Full=Oxysterol 7-alpha-hydroxylase [Mus musculus]
GI:552953856 SwissProt Q9JKJ9.1 470 RecName: Full=24-hydroxycholesterol 7-alpha-hydroxylase; AltName: Full=Cytochrome P450 39A1; Short=mCYP39A1; AltName: Full=Oxysterol 7-alpha-hydroxylase [Mus musculus]