Gene/Proteome Database (LMPD)

LMPD ID
LMP002309
Gene ID
238377
Species
Mus musculus (Mouse)
Gene Name
G protein-coupled receptor 68
Gene Symbol
Gpr68
Synonyms
BB131428; Ogr1
Alternate Names
ovarian cancer G-protein coupled receptor 1; G-protein coupled receptor 68; sphingosylphosphorylcholine receptor
Chromosome
12
Map Location
12 E|12

Proteins

ovarian cancer G-protein coupled receptor 1
Refseq ID NP_780702
Protein GI 28202053
UniProt ID Q8BFQ3
mRNA ID NM_175493
Length 365
RefSeq Status VALIDATED
MGNITTENSSLSCPIDHTIHQTLAPVVYVTVLVVGFPANCLSLYFGYLQIKARNELGVYLCNLTIADLFYICSLPFWLQYVLQHDDWSHGDLSCQVCGILLYENIYISVGFLCCISIDRYLAVAHPFRFHQFRTLKAAVGVSVLIWAKELLTSIYFLNHKEVIEDEDQHRVCFEHYPIQAWQRSINYYRFLVGFLFPICLLLASYQGILRAVRRSHGTQKSRKDQIQRLVLSTVVIFLACFLPYHVLLLVRSLWERNCEFAKSIFNVYHFSLLLTSFNCVADPVLYCFVSETTHRDLARLRGACLAVLTCSRTSRAREAYPLGAPEASGKSGAQGEEPELLTKLHSAFQTPSSLGVGGPSTVGLA
ovarian cancer G-protein coupled receptor 1
Refseq ID NP_001171144
Protein GI 295054306
UniProt ID Q8BFQ3
mRNA ID NM_001177673
Length 365
RefSeq Status VALIDATED
Protein sequence is identical to GI:28202053 (mRNA isoform)
ovarian cancer G-protein coupled receptor 1
Refseq ID NP_001171145
Protein GI 295054310
UniProt ID Q8BFQ3
mRNA ID NM_001177674
Length 365
RefSeq Status VALIDATED
Protein sequence is identical to GI:28202053 (mRNA isoform)

Gene Information

Entrez Gene ID
238377
Gene Name
G protein-coupled receptor 68
Gene Symbol
Gpr68
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0004930 IEA:UniProtKB-KW F G-protein coupled receptor activity
GO:0071467 IMP:MGI P cellular response to pH
GO:0045656 IMP:MGI P negative regulation of monocyte differentiation
GO:0032024 IMP:MGI P positive regulation of insulin secretion
GO:0035774 IMP:MGI P positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:2001206 IMP:MGI P positive regulation of osteoclast development

REACTOME Pathway Links

REACTOME Pathway ID Description
5893633 Class A/1 (Rhodopsin-like receptors)
5893152 GPCR downstream signaling

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR005389 OGR1 sphingosylphosphorylcholine receptor

UniProt Annotations

Entry Information

Gene Name
G protein-coupled receptor 68
Protein Entry
OGR1_MOUSE
UniProt ID
Q8BFQ3
Species
Mouse

Comments

Comment Type Description
Disruption Phenotype Mice have reduced osteoclasts derived from bone marrow cells, a pH-dependent osteoclast survival effect is also detected. However, the overall bone structures of the mice are not affected. In addition melanoma cell tumorigenesis is significantly inhibited. {ECO:0000269|PubMed:19479052}.
Function Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer. {ECO:0000269|PubMed:17728215, ECO:0000269|PubMed:18847331}.
Sequence Caution Sequence=AAI18035.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI18045.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC29521.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC39863.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE33483.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Expressed in the lung, testis, heart, brain, spleen, thymus, brown fat, small intestine, colon, peripheral blood leukocytes, macrophages, stomach, ovary and white fat but not in the liver, kidney, and skeletal muscle. Expression in the prostate is weak but detectable. {ECO:0000269|PubMed:19479052}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002309 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
28202053 RefSeq NP_780702 365 ovarian cancer G-protein coupled receptor 1

Identical Sequences to LMP002309 proteins

Reference Database Accession Length Protein Name
GI:28202053 DBBJ BAE33483.1 365 unnamed protein product [Mus musculus]
GI:28202053 GenBank AAI18045.2 365 G protein-coupled receptor 68 [Mus musculus]
GI:28202053 GenBank AAI18035.2 365 G protein-coupled receptor 68 [Mus musculus]
GI:28202053 RefSeq NP_001171144.1 365 ovarian cancer G-protein coupled receptor 1 [Mus musculus]
GI:28202053 RefSeq NP_001171145.1 365 ovarian cancer G-protein coupled receptor 1 [Mus musculus]
GI:28202053 SwissProt Q8BFQ3.1 365 RecName: Full=Ovarian cancer G-protein coupled receptor 1; AltName: Full=G-protein coupled receptor 68; AltName: Full=Sphingosylphosphorylcholine receptor [Mus musculus]

Related Sequences to LMP002309 proteins

Reference Database Accession Length Protein Name
GI:28202053 DBBJ BAE32740.1 365 unnamed protein product [Mus musculus]
GI:28202053 GenBank EDL18887.1 375 G protein-coupled receptor 68, isoform CRA_a [Mus musculus]
GI:28202053 GenBank EDL18888.1 375 G protein-coupled receptor 68, isoform CRA_a [Mus musculus]
GI:28202053 GenBank EDL18889.1 375 G protein-coupled receptor 68, isoform CRA_a [Mus musculus]
GI:28202053 GenBank EDL18890.1 375 G protein-coupled receptor 68, isoform CRA_a [Mus musculus]
GI:28202053 RefSeq XP_006240515.1 375 PREDICTED: ovarian cancer G-protein coupled receptor 1 [Rattus norvegicus]