Gene/Proteome Database (LMPD)

LMPD ID
LMP002312
Gene ID
4547
Species
Homo sapiens (Human)
Gene Name
microsomal triglyceride transfer protein
Gene Symbol
MTTP
Synonyms
ABL; MTP
Chromosome
4
Map Location
4q24
Summary
MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for MTTP

Proteins

microsomal triglyceride transfer protein large subunit isoform 1 precursor
Refseq ID NP_000244
Protein GI 153285408
UniProt ID P55157
mRNA ID NM_000253
Length 894
RefSeq Status REVIEWED
MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRISSNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGLNFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKGCPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLVDAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIGSSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNALLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVRTAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEMVAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLHGSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKNRVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQFEKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
microsomal triglyceride transfer protein large subunit isoform 2
Refseq ID NP_001287714
Protein GI 153285408
UniProt ID P55157
mRNA ID NM_001300785
Length 894
RefSeq Status REVIEWED
MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRISSNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGLNFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKGCPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLVDAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIGSSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNALLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVRTAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEMVAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLHGSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKNRVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQFEKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
sig_peptide: 1..18 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (P55157.1) calculated_mol_wt: 1978 peptide sequence: MILLAVLFLCFISSYSAS mat_peptide: 19..894 product: Microsomal triglyceride transfer protein large subunit experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P55157.1) calculated_mol_wt: 97391 peptide sequence: VKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRISSNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGLNFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKGCPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLVDAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIGSSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNALLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVRTAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEMVAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLHGSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKNRVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQFEKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF

Gene Information

Entrez Gene ID
4547
Gene Name
microsomal triglyceride transfer protein
Gene Symbol
MTTP
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:Ensembl C Golgi apparatus
GO:0016323 IEA:Ensembl C basolateral plasma membrane
GO:0031526 IEA:Ensembl C brush border membrane
GO:0005788 TAS:Reactome C endoplasmic reticulum lumen
GO:0031988 IEA:Ensembl C membrane-bounded vesicle
GO:0031528 IEA:Ensembl C microvillus membrane
GO:0043235 IDA:MGI C receptor complex
GO:0005791 IEA:Ensembl C rough endoplasmic reticulum
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0005319 TAS:Reactome F lipid transporter activity
GO:0042632 IEA:Ensembl P cholesterol homeostasis
GO:0006629 TAS:ProtInc P lipid metabolic process
GO:0042157 TAS:Reactome P lipoprotein metabolic process
GO:0042953 IEA:Ensembl P lipoprotein transport
GO:0006497 IEA:Ensembl P protein lipidation
GO:0051592 IEA:Ensembl P response to calcium ion
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006641 IEA:Ensembl P triglyceride metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04975 Fat digestion and absorption
ko04975 Fat digestion and absorption

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_6841 Chylomicron-mediated lipid transport

Domain Information

InterPro Annotations

Accession Description
IPR001747 Lipid transport protein, N-terminal
IPR015819 Lipid transport protein, beta-sheet shell
IPR015816 Vitellinogen, beta-sheet N-terminal
IPR011030 Vitellinogen, superhelical

UniProt Annotations

Entry Information

Gene Name
microsomal triglyceride transfer protein
Protein Entry
B7Z7X3_HUMAN
UniProt ID
P55157
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P55157-1; Sequence=Displayed; Name=2; IsoId=P55157-2; Sequence=VSP_056325, VSP_056326; Note=No experimental confirmation available.;
Disease Abetalipoproteinemia (ABL) [MIM
Function Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B.
Induction Positively regulated by cholesterol and negatively regulated by insulin.
Similarity Contains 1 vitellogenin domain. {ECO
Subcellular Location Endoplasmic reticulum.
Subunit Heterodimer composed of MTTP and of protein disulfide isomerase (P4HB/PDI).
Tissue Specificity Liver and small intestine. Also found in ovary, testis and kidney.

Identical and Related Proteins

Unique RefSeq proteins for LMP002312 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
153285408 RefSeq NP_000244 894 microsomal triglyceride transfer protein large subunit isoform 1 precursor
153285408 RefSeq NP_001287714 894 microsomal triglyceride transfer protein large subunit isoform 2

Identical Sequences to LMP002312 proteins

Reference Database Accession Length Protein Name
GI:153285408 DBBJ BAF83482.1 894 unnamed protein product [Homo sapiens]
GI:153285408 DBBJ BAF83482.1 894 unnamed protein product [Homo sapiens]
GI:153285408 EMBL CAA58142.1 894 MTP [Homo sapiens]
GI:153285408 EMBL CAA58142.1 894 MTP [Homo sapiens]
GI:153285408 GenBank AAI25112.1 894 Microsomal triglyceride transfer protein [Homo sapiens]
GI:153285408 GenBank AAI25112.1 894 Microsomal triglyceride transfer protein [Homo sapiens]
GI:153285408 GenBank AAI25111.1 894 Microsomal triglyceride transfer protein [Homo sapiens]
GI:153285408 GenBank AAI25111.1 894 Microsomal triglyceride transfer protein [Homo sapiens]
GI:153285408 GenBank AGU30787.1 894 Sequence 93 from patent US 8506948
GI:153285408 GenBank AGU30787.1 894 Sequence 93 from patent US 8506948
GI:153285408 SwissProt P55157.1 894 RecName: Full=Microsomal triglyceride transfer protein large subunit; Flags: Precursor [Homo sapiens]
GI:153285408 SwissProt P55157.1 894 RecName: Full=Microsomal triglyceride transfer protein large subunit; Flags: Precursor [Homo sapiens]

Related Sequences to LMP002312 proteins

Reference Database Accession Length Protein Name
GI:153285408 EMBL CAA42200.1 894 microsomal triglyceride transfer protein [Homo sapiens]
GI:153285408 EMBL CAA42200.1 894 microsomal triglyceride transfer protein [Homo sapiens]
GI:153285408 GenBank ABY15162.1 894 Sequence 537 from patent US 7306913
GI:153285408 GenBank ABY15162.1 894 Sequence 537 from patent US 7306913
GI:153285408 GenBank ADS31023.1 894 Sequence 1555 from patent US 7781168
GI:153285408 GenBank ADS31023.1 894 Sequence 1555 from patent US 7781168
GI:153285408 GenBank ADS87553.1 894 Sequence 429 from patent US 7820380
GI:153285408 GenBank ADS87553.1 894 Sequence 429 from patent US 7820380
GI:153285408 GenBank AEW40548.1 894 Sequence 429 from patent US 8071302
GI:153285408 GenBank AEW40548.1 894 Sequence 429 from patent US 8071302
GI:153285408 GenBank AHE02279.1 894 Sequence 60633 from patent US 8586006
GI:153285408 GenBank AHE02279.1 894 Sequence 60633 from patent US 8586006