Gene/Proteome Database (LMPD)
LMPD ID
LMP002314
Gene ID
Species
Homo sapiens (Human)
Gene Name
solute carrier family 27 (fatty acid transporter), member 6
Gene Symbol
Synonyms
ACSVL2; FACVL2; FATP6; VLCS-H1
Alternate Names
long-chain fatty acid transport protein 6; FATP-6; VLCSH1; hVLCS-H1; fatty acid transport protein 6; solute carrier family 27 member 6; very long-chain acyl-CoA synthetase homolog 1; fatty-acid-Coenzyme A ligase, very long-chain 2
Chromosome
5
Map Location
5q23.3
Summary
This gene encodes a member of the fatty acid transport protein family (FATP). FATPs are involved in the uptake of long-chain fatty acids and have unique expression patterns. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| long-chain fatty acid transport protein 6 | |
|---|---|
| Refseq ID | NP_054750 |
| Protein GI | 13325055 |
| UniProt ID | Q9Y2P4 |
| mRNA ID | NM_014031 |
| Length | 619 |
| RefSeq Status | REVIEWED |
| MLLSWLTVLGAGMVVLHFLQKLLFPYFWDDFWFVLKVVLIIIRLKKYEKRGELVTVLDKFLSHAKRQPRKPFIIYEGDIYTYQDVDKRSSRVAHVFLNHSSLKKGDTVALLMSNEPDFVHVWFGLAKLGCVVAFLNTNIRSNSLLNCIRACGPRALVVGADLLGTVEEILPSLSENISVWGMKDSVPQGVISLKEKLSTSPDEPVPRSHHVVSLLKSTCLYIFTSGTTGLPKAAVISQLQVLRGSAVLWAFGCTAHDIVYITLPLYHSSAAILGISGCVELGATCVLKKKFSASQFWSDCKKYDVTVFQYIGELCRYLCKQSKREGEKDHKVRLAIGNGIRSDVWREFLDRFGNIKVCELYAATESSISFMNYTGRIGAIGRTNLFYKLLSTFDLIKYDFQKDEPMRNEQGWCIHVKKGEPGLLISRVNAKNPFFGYAGPYKHTKDKLLCDVFKKGDVYLNTGDLIVQDQDNFLYFWDRTGDTFRWKGENVATTEVADVIGMLDFIQEANVYGVAISGYEGRAGMASIILKPNTSLDLEKVYEQVVTFLPAYACPRFLRIQEKMEATGTFKLLKHQLVEDGFNPLKISEPLYFMDNLKKSYVLLTRELYDQIMLGEIKL | |
| long-chain fatty acid transport protein 6 | |
|---|---|
| Refseq ID | NP_001017372 |
| Protein GI | 62865631 |
| UniProt ID | Q9Y2P4 |
| mRNA ID | NM_001017372 |
| Length | 619 |
| RefSeq Status | REVIEWED |
| Protein sequence is identical to GI:13325055 (mRNA isoform) | |
Gene Information
Entrez Gene ID
Gene Name
solute carrier family 27 (fatty acid transporter), member 6
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005886 | TAS:Reactome | C | plasma membrane |
| GO:0004467 | TAS:ProtInc | F | long-chain fatty acid-CoA ligase activity |
| GO:0000166 | IEA:UniProtKB-KW | F | nucleotide binding |
| GO:0031957 | IEA:Ensembl | F | very long-chain fatty acid-CoA ligase activity |
| GO:0001676 | TAS:GOC | P | long-chain fatty acid metabolic process |
| GO:0015909 | TAS:Reactome | P | long-chain fatty acid transport |
| GO:0055085 | TAS:Reactome | P | transmembrane transport |
| GO:0000038 | TAS:ProtInc | P | very long-chain fatty acid metabolic process |
KEGG Pathway Links
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_23892 | Transport of fatty acids |
| REACT_22285 | Transport of vitamins, nucleosides, and related molecules |
Domain Information
UniProt Annotations
Entry Information
Gene Name
solute carrier family 27 (fatty acid transporter), member 6
Protein Entry
S27A6_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Function | Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart. |
| Similarity | Belongs to the ATP-dependent AMP-binding enzyme family. |
| Subcellular Location | Membrane ; Multi-pass membrane protein {ECO |
| Tissue Specificity | Strongly expressed in heart and localizes to cardiac myocytes. Expressed at moderate levels in placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002314 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 13325055 | RefSeq | NP_054750 | 619 | long-chain fatty acid transport protein 6 |
Identical Sequences to LMP002314 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:13325055 | GenBank | ABH70746.1 | 619 | Sequence 57 from patent US 7033772 |
| GI:13325055 | RefSeq | XP_005272024.1 | 619 | PREDICTED: long-chain fatty acid transport protein 6 isoform X1 [Homo sapiens] |
| GI:13325055 | RefSeq | XP_005272025.1 | 619 | PREDICTED: long-chain fatty acid transport protein 6 isoform X2 [Homo sapiens] |
| GI:13325055 | RefSeq | XP_005272026.1 | 619 | PREDICTED: long-chain fatty acid transport protein 6 isoform X3 [Homo sapiens] |
| GI:13325055 | RefSeq | XP_005272027.1 | 619 | PREDICTED: long-chain fatty acid transport protein 6 isoform X4 [Homo sapiens] |
| GI:13325055 | RefSeq | XP_005272028.1 | 619 | PREDICTED: long-chain fatty acid transport protein 6 isoform X5 [Homo sapiens] |
Related Sequences to LMP002314 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:13325055 | GenBank | EAW62387.1 | 619 | solute carrier family 27 (fatty acid transporter), member 6 [Homo sapiens] |
| GI:13325055 | GenBank | ACP57292.1 | 619 | Sequence 1421 from patent US 7482117 |
| GI:13325055 | GenBank | ACP57293.1 | 619 | Sequence 1422 from patent US 7482117 |
| GI:13325055 | GenBank | ADS30889.1 | 619 | Sequence 1421 from patent US 7781168 |
| GI:13325055 | GenBank | ADS30890.1 | 619 | Sequence 1422 from patent US 7781168 |
| GI:13325055 | GenBank | ADT50171.1 | 619 | Sequence 2188 from patent US 7842467 |