Gene/Proteome Database (LMPD)

LMPD ID
LMP002315
Gene ID
10998
Species
Homo sapiens (Human)
Gene Name
solute carrier family 27 (fatty acid transporter), member 5
Gene Symbol
SLC27A5
Synonyms
ACSB; ACSVL6; BACS; BAL; FACVL3; FATP-5; FATP5; VLACSR; VLCS-H2; VLCSH2
Alternate Names
bile acyl-CoA synthetase; BA-CoA ligase; VLACS-related; cholate--CoA ligase; bile acid-CoA ligase; fatty acid transport protein 5; solute carrier family 27 member 5; very long-chain acyl-CoA synthetase homolog 2; fatty-acid-Coenzyme A ligase, very long-chain 3; very long-chain acyl-CoA synthetase-related protein
Chromosome
19
Map Location
19q13.43
EC Number
6.2.1.7
Summary
The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for SLC27A5

Proteins

bile acyl-CoA synthetase precursor
Refseq ID NP_036386
Protein GI 13325057
UniProt ID Q9Y2P5
mRNA ID NM_012254
Length 690
RefSeq Status REVIEWED
MGVRQQLALLLLLLLLLWGLGQPVWPVAVALTLRWLLGDPTCCVLLGLAMLARPWLGPWVPHGLSLAAAALALTLLPARLPPGLRWLPADVIFLAKILHLGLKIRGCLSRQPPDTFVDAFERRARAQPGRALLVWTGPGAGSVTFGELDARACQAAWALKAELGDPASLCAGEPTALLVLASQAVPALCMWLGLAKLGCPTAWINPHGRGMPLAHSVLSSGARVLVVDPDLRESLEEILPKLQAENIRCFYLSHTSPTPGVGALGAALDAAPSHPVPADLRAGITWRSPALFIYTSGTTGLPKPAILTHERVLQMSKMLSLSGATADDVVYTVLPLYHVMGLVVGILGCLDLGATCVLAPKFSTSCFWDDCRQHGVTVILYVGELLRYLCNIPQQPEDRTHTVRLAMGNGLRADVWETFQQRFGPIRIWEVYGSTEGNMGLVNYVGRCGALGKMSCLLRMLSPFELVQFDMEAAEPVRDNQGFCIPVGLGEPGLLLTKVVSQQPFVGYRGPRELSERKLVRNVRQSGDVYYNTGDVLAMDREGFLYFRDRLGDTFRWKGENVSTHEVEGVLSQVDFLQQVNVYGVCVPGCEGKVGMAAVQLAPGQTFDGEKLYQHVRAWLPAYATPHFIRIQDAMEVTSTFKLMKTRLVREGFNVGIVVDPLFVLDNRAQSFRPLTAEMYQAVCEGTWRL
sig_peptide: 1..21 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2334 peptide sequence: MGVRQQLALLLLLLLLLWGLG

Gene Information

Entrez Gene ID
10998
Gene Name
solute carrier family 27 (fatty acid transporter), member 5
Gene Symbol
SLC27A5
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009925 IEA:Ensembl C basal plasma membrane
GO:0005783 IDA:UniProtKB C endoplasmic reticulum
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0030176 IDA:UniProtKB C integral component of endoplasmic reticulum membrane
GO:0043234 IEA:Ensembl C protein complex
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0047747 IEA:UniProtKB-EC F cholate-CoA ligase activity
GO:0015245 IEA:Ensembl F fatty acid transporter activity
GO:0031957 IDA:UniProtKB F very long-chain fatty acid-CoA ligase activity
GO:0015721 TAS:Reactome P bile acid and bile salt transport
GO:0006699 IDA:UniProtKB P bile acid biosynthetic process
GO:0008206 TAS:Reactome P bile acid metabolic process
GO:0046951 IEA:Ensembl P ketone body biosynthetic process
GO:0015911 IEA:Ensembl P plasma membrane long-chain fatty acid transport
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006642 IEA:Ensembl P triglyceride mobilization
GO:0000038 IDA:UniProtKB P very long-chain fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04976 Bile secretion
hsa03320 PPAR signaling pathway
hsa00120 Primary bile acid biosynthesis

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6061 bile acid biosynthesis, neutral pathway

Domain Information

InterPro Annotations

Accession Description
IPR025110 AMP-binding enzyme C-terminal domain
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
solute carrier family 27 (fatty acid transporter), member 5
Protein Entry
S27A5_HUMAN
UniProt ID
Q9Y2P5
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y2P5-1; Sequence=Displayed; Name=2; IsoId=Q9Y2P5-2; Sequence=VSP_055810; Note=No experimental confirmation available.;
Catalytic Activity ATP + (25R)-3-alpha,7-alpha,12-alpha- trihydroxy-5-beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA.
Catalytic Activity ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA.
Function Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. {ECO
Similarity Belongs to the ATP-dependent AMP-binding enzyme family.
Subcellular Location Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue Specificity Predominantly expressed in liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP002315 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13325057 RefSeq NP_036386 690 bile acyl-CoA synthetase precursor

Identical Sequences to LMP002315 proteins

Reference Database Accession Length Protein Name
GI:13325057 DBBJ BAG53858.1 690 unnamed protein product [Homo sapiens]
GI:13325057 DBBJ BAI45376.1 690 solute carrier family 27 (fatty acid transporter), member 5, partial [synthetic construct]
GI:13325057 GenBank EAW72601.1 690 solute carrier family 27 (fatty acid transporter), member 5 [Homo sapiens]
GI:13325057 GenBank AAI46388.1 690 Solute carrier family 27 (fatty acid transporter), member 5, partial [synthetic construct]
GI:13325057 GenBank AAI48808.1 690 Solute carrier family 27 (fatty acid transporter), member 5 [synthetic construct]
GI:13325057 GenBank AHD77378.1 690 Sequence 22511 from patent US 8586006

Related Sequences to LMP002315 proteins

Reference Database Accession Length Protein Name
GI:13325057 GenBank EHH30499.1 690 hypothetical protein EGK_11181 [Macaca mulatta]
GI:13325057 RefSeq XP_001148729.1 690 PREDICTED: bile acyl-CoA synthetase isoform X1 [Pan troglodytes]
GI:13325057 RefSeq XP_003816674.1 690 PREDICTED: bile acyl-CoA synthetase isoform X1 [Pan paniscus]
GI:13325057 RefSeq XP_003916316.1 690 PREDICTED: bile acyl-CoA synthetase isoform X2 [Papio anubis]
GI:13325057 RefSeq XP_005590672.1 690 PREDICTED: bile acyl-CoA synthetase isoform X1 [Macaca fascicularis]
GI:13325057 RefSeq XP_009193810.1 690 PREDICTED: bile acyl-CoA synthetase isoform X1 [Papio anubis]