Gene/Proteome Database (LMPD)

LMPD ID
LMP002321
Gene ID
77974
Species
Mus musculus (Mouse)
Gene Name
retinol dehydrogenase 12
Gene Symbol
Rdh12
Synonyms
A930033N07Rik
Alternate Names
retinol dehydrogenase 12
Chromosome
12
Map Location
12|12 D2
EC Number
1.1.1.-

Proteins

retinol dehydrogenase 12 precursor
Refseq ID NP_084293
Protein GI 58037513
UniProt ID Q8BYK4
mRNA ID NM_030017
Length 316
RefSeq Status PROVISIONAL
MLFILVLLTSFLSILYLTAPSIRKFFAGGVCTTNVQIPGKVVVITGANTGIGKETARELARRGARVYIACRDVLKGESAASEIRADTKNSQVLVRKLDLSDTKSIRAFAERFLAEEKKLHILINNAGVMMCPYSKTTDGFETHFGVNHLGHFLLTYLLLERLKESAPARVVNLSSIAHLIGKIRFHDLQGQKRYCSAFAYGHSKLANLLFTRELAKRLQGTGVTAYAVHPGVVLSEITRNSYLLCLLWRLFSPFFKSTSQGAQTSLHCALAEDLEPLSGKYFSDCKRMWVSSRARNKKTAERLWNVSCELLGIQWE
sig_peptide: 1..19 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2172 peptide sequence: MLFILVLLTSFLSILYLTA

Gene Information

Entrez Gene ID
77974
Gene Name
retinol dehydrogenase 12
Gene Symbol
Rdh12
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005622 ISS:UniProtKB C intracellular
GO:0004745 ISS:UniProtKB F retinol dehydrogenase activity
GO:0050896 IEA:UniProtKB-KW P response to stimulus
GO:0042572 ISS:UniProtKB P retinol metabolic process
GO:0007601 IEA:UniProtKB-KW P visual perception

KEGG Pathway Links

KEGG Pathway ID Description
mmu01100 Metabolic pathways
mmu00830 Retinol metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5892894 The canonical retinoid cycle in rods (twilight vision)

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR

UniProt Annotations

Entry Information

Gene Name
retinol dehydrogenase 12
Protein Entry
RDH12_MOUSE
UniProt ID
Q8BYK4
Species
Mouse

Comments

Comment Type Description
Function Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments (By similarity). {ECO:0000250}.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002321 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
58037513 RefSeq NP_084293 316 retinol dehydrogenase 12 precursor

Identical Sequences to LMP002321 proteins

Reference Database Accession Length Protein Name
GI:58037513 DBBJ BAC30288.1 316 unnamed protein product [Mus musculus]
GI:58037513 GenBank EDL02645.1 316 retinol dehydrogenase 12, isoform CRA_b [Mus musculus]
GI:58037513 SwissProt Q8BYK4.1 316 RecName: Full=Retinol dehydrogenase 12 [Mus musculus]

Related Sequences to LMP002321 proteins

Reference Database Accession Length Protein Name
GI:58037513 DBBJ BAB32258.1 316 unnamed protein product [Mus musculus]
GI:58037513 GenBank AAH16204.1 304 Rdh12 protein [Mus musculus]
GI:58037513 GenBank EDL02644.1 315 retinol dehydrogenase 12, isoform CRA_a, partial [Mus musculus]
GI:58037513 RefSeq XP_005072793.1 316 PREDICTED: retinol dehydrogenase 12 [Mesocricetus auratus]
GI:58037513 RefSeq XP_005343320.1 316 PREDICTED: retinol dehydrogenase 12 [Microtus ochrogaster]
GI:58037513 RefSeq XP_006516435.1 295 PREDICTED: retinol dehydrogenase 12 isoform X1 [Mus musculus]