Gene/Proteome Database (LMPD)

LMPD ID
LMP002333
Gene ID
8416
Species
Homo sapiens (Human)
Gene Name
annexin A9
Gene Symbol
ANXA9
Synonyms
ANX31
Alternate Names
annexin A9; annexin-9; pemphaxin; annexin 31; annexin-31; annexin XXXI
Chromosome
1
Map Location
1q21
Summary
The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for ANXA9

Proteins

annexin A9
Refseq ID NP_003559
Protein GI 145864465
UniProt ID O76027
mRNA ID NM_003568
Length 345
RefSeq Status VALIDATED
MSVTGGKMAPSLTQEILSHLGLASKTAAWGTLGTLRTFLNFSVDKDAQRLLRAITGQGVDRSAIVDVLTNRSREQRQLISRNFQERTQQDLMKSLQAALSGNLERIVMALLQPTAQFDAQELRTALKASDSAVDVAIEILATRTPPQLQECLAVYKHNFQVEAVDDITSETSGILQDLLLALAKGGRDSYSGIIDYNLAEQDVQALQRAEGPSREETWVPVFTQRNPEHLIRVFDQYQRSTGQELEEAVQNRFHGDAQVALLGLASVIKNTPLYFADKLHQALQETEPNYQVLIRILISRCETDLLSIRAEFRKKFGKSLYSSLQDAVKGDCQSALLALCRAEDM

Gene Information

Entrez Gene ID
8416
Gene Name
annexin A9
Gene Symbol
ANXA9
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009986 IDA:UniProtKB C cell surface
GO:0005829 IDA:UniProtKB C cytosol
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0015464 IDA:UniProtKB F acetylcholine receptor activity
GO:0005544 IEA:InterPro F calcium-dependent phospholipid binding
GO:0005509 IEA:InterPro F calcium ion binding
GO:0001786 IDA:UniProtKB F phosphatidylserine binding
GO:0005543 IDA:UniProtKB F phospholipid binding
GO:0042803 TAS:UniProtKB F protein homodimerization activity
GO:0016337 IDA:UniProtKB P single organismal cell-cell adhesion
GO:0007268 IDA:GOC P synaptic transmission

Domain Information

InterPro Annotations

Accession Description
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin repeat, conserved site
IPR009116 Annexin, type XXXI

UniProt Annotations

Entry Information

Gene Name
annexin A9
Protein Entry
ANXA9_HUMAN
UniProt ID
O76027
Species
Human

Comments

Comment Type Description
Function Low affinity receptor for acetylcholine known to be targeted by disease-causing pemphigus vulgaris antibodies in keratinocytes.
Interaction O60437:PPL; NbExp=6; IntAct=EBI-720960, EBI-368321;
Sequence Caution Sequence=AAH05830.2; Type=Erroneous initiation; Evidence= ; Sequence=CAA08933.1; Type=Frameshift; Positions=7; Evidence= ;
Similarity Belongs to the annexin family.
Similarity Contains 4 annexin repeats.
Subunit Homodimer.
Tissue Specificity Expressed in the stratified squamous skin epithelium, but not in epithelia of other types (at protein level).

Identical and Related Proteins

Unique RefSeq proteins for LMP002333 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
145864465 RefSeq NP_003559 345 annexin A9

Identical Sequences to LMP002333 proteins

Reference Database Accession Length Protein Name
GI:145864465 EMBL CCV20016.1 345 unnamed protein product [Homo sapiens]
GI:145864465 GenBank EAW53496.1 345 annexin A9 [Homo sapiens]
GI:145864465 GenBank ABM83945.1 345 annexin A9 [synthetic construct]
GI:145864465 GenBank ABM87263.1 345 annexin A9, partial [synthetic construct]
GI:145864465 SwissProt O76027.3 345 RecName: Full=Annexin A9; AltName: Full=Annexin XXXI; AltName: Full=Annexin-31; AltName: Full=Annexin-9; AltName: Full=Pemphaxin [Homo sapiens]

Related Sequences to LMP002333 proteins

Reference Database Accession Length Protein Name
GI:145864465 GenBank AAG16780.1 345 keratinocyte annexin-like protein pemphaxin [Homo sapiens]
GI:145864465 GenBank AAP36855.1 346 Homo sapiens annexin A9, partial [synthetic construct]
GI:145864465 GenBank AAX29126.1 346 annexin A9, partial [synthetic construct]
GI:145864465 GenBank AAX29127.1 346 annexin A9, partial [synthetic construct]
GI:145864465 RefSeq XP_513782.2 345 PREDICTED: annexin A9 isoform X2 [Pan troglodytes]
GI:145864465 RefSeq XP_003817327.1 345 PREDICTED: annexin A9 isoform X2 [Pan paniscus]