Gene/Proteome Database (LMPD)
LMPD ID
LMP002334
Gene ID
Species
Homo sapiens (Human)
Gene Name
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
Gene Symbol
Synonyms
ATPASEII; ATPIA; ATPP2
Alternate Names
phospholipid-transporting ATPase IA; ATPase II; chromaffin granule ATPase II; aminophospholipid translocase; ATPase class I type 8A member 1; probable phospholipid-transporting ATPase IA; P4-ATPase flippase complex alpha subunit ATP8A1
Chromosome
4
Map Location
4p13
EC Number
3.6.3.1
Summary
The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily catalyzes transport of heavy metal ions. Another subfamily transports non-heavy metal ions (NMHI). The protein encoded by this gene is a member of the third subfamily of P-type ATPases and acts to transport amphipaths, such as phosphatidylserine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| phospholipid-transporting ATPase IA isoform a | |
|---|---|
| Refseq ID | NP_006086 |
| Protein GI | 17978471 |
| UniProt ID | Q9Y2Q0 |
| mRNA ID | NM_006095 |
| Length | 1164 |
| RefSeq Status | REVIEWED |
| MPTMRRTVSEIRSRAEGYEKTDDVSEKTSLADQEEVRTIFINQPQLTKFCNNHVSTAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEPQAMCYIETSNLDGETNLKIRQGLPATSDIKDVDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLNLNYGGASNFGLNFLTFIILFNNLIPISLLVTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGHVPEPEDYGCSPDEWQNSQFGDEKTFSDSSLLENLQNNHPTAPIICEFLTMMAVCHTAVPEREGDKIIYQAASPDEGALVRAAKQLNFVFTGRTPDSVIIDSLGQEERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRLAETSKYKEITLKHLEQFATEGLRTLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGMIVINEGSLDGTRETLSRHCTTLGDALRKENDFALIIDGKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTAFGNGKTSDYLLLGNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVVFFGIYSSLWPAIPMAPDMSGEAAMLFSSGVFWMGLLFIPVASLLLDVVYKVIKRTAFKTLVDEVQELEAKSQDPGAVVLGKSLTERAQLLKNVFKKNHVNLYRSESLQQNLLHGYAFSQDENGIVSQSEVIRAYDTTKQRPDEW | |
| phospholipid-transporting ATPase IA isoform b | |
|---|---|
| Refseq ID | NP_001098999 |
| Protein GI | 157649069 |
| UniProt ID | Q9Y2Q0 |
| mRNA ID | NM_001105529 |
| Length | 1149 |
| RefSeq Status | REVIEWED |
| MPTMRRTVSEIRSRAEGYEKTDDVSEKTSLADQEEVRTIFINQPQLTKFCNNHVSTAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRNGAWEIVHWEKVNVGDIVIIKGKEYIPADTVLLSSSEPQAMCYIETSNLDGETNLKIRQGLPATSDIKDVDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLNLNYGGASNFGLNFLTFIILFNNLIPISLLVTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGQNSQFGDEKTFSDSSLLENLQNNHPTAPIICEFLTMMAVCHTAVPEREGDKIIYQAASPDEGALVRAAKQLNFVFTGRTPDSVIIDSLGQEERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRLAETSKYKEITLKHLEQFATEGLRTLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGMIVINEGSLDGTRETLSRHCTTLGDALRKENDFALIIDGKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTAFGNGKTSDYLLLGNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVVFFGIYSSLWPAIPMAPDMSGEAAMLFSSGVFWMGLLFIPVASLLLDVVYKVIKRTAFKTLVDEVQELEAKSQDPGAVVLGKSLTERAQLLKNVFKKNHVNLYRSESLQQNLLHGYAFSQDENGIVSQSEVIRAYDTTKQRPDEW | |
Gene Information
Entrez Gene ID
Gene Name
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0031410 | IEA:UniProtKB-KW | C | cytoplasmic vesicle |
| GO:0005783 | IDA:UniProtKB | C | endoplasmic reticulum |
| GO:0070062 | IDA:UniProtKB | C | extracellular vesicular exosome |
| GO:0005794 | IDA:UniProtKB | C | Golgi apparatus |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0016020 | IDA:UniProtKB | C | membrane |
| GO:0005886 | IDA:UniProtKB | C | plasma membrane |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0019829 | NAS:UniProtKB | F | cation-transporting ATPase activity |
| GO:0000287 | IEA:InterPro | F | magnesium ion binding |
| GO:0004012 | IEA:UniProtKB-EC | F | phospholipid-translocating ATPase activity |
| GO:0098655 | NAS:GOC | P | cation transmembrane transport |
| GO:0034220 | TAS:Reactome | P | ion transmembrane transport |
| GO:0045332 | NAS:UniProtKB | P | phospholipid translocation |
| GO:0055085 | TAS:Reactome | P | transmembrane transport |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_25300 | Ion channel transport |
| REACT_25149 | Ion transport by P-type ATPases |
| REACT_15518 | Transmembrane transport of small molecules |
Domain Information
UniProt Annotations
Entry Information
Gene Name
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
Protein Entry
AT8A1_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long; IsoId=Q9Y2Q0-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y2Q0-2; Sequence=VSP_000431; Name=3; IsoId=Q9Y2Q0-3; Sequence=VSP_040977, VSP_000431; |
| Catalytic Activity | ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2). |
| Enzyme Regulation | ATPase activity is stimulated by phosphatidylserine (PS) and minimally by phosphatidylethanolamine (PE). |
| Function | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells. |
| Sequence Caution | Sequence=AAI09318.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAA77248.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; |
| Similarity | Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. |
| Subcellular Location | Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane ; Multi-pass membrane protein . Cytoplasmic granule. Cell membrane. Endoplasmic reticulum. Golgi apparatus. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in cytoplasmic punctate structures and localizes to the plasma membrane. Localizes to plasma membranes of red blood cells (By similarity). |
| Subunit | Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit. Interacts with TMEM30A to form a flippase complex; the interaction with TMEM30B is reported conflictingly. {ECO |
| Tissue Specificity | Found in most adult tissues except liver, testis and placenta. Most abundant in heart, brain and skeletal muscle. Also detected in fetal tissues. Isoform 1 is only detected in brain, skeletal muscle and heart and is the most abundant form in skeletal muscle. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002334 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 17978471 | RefSeq | NP_006086 | 1164 | phospholipid-transporting ATPase IA isoform a |
| 157649069 | RefSeq | NP_001098999 | 1149 | phospholipid-transporting ATPase IA isoform b |
Identical Sequences to LMP002334 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:17978471 | GenBank | AAD34706.1 | 1164 | ATPase II, partial [Homo sapiens] |
| GI:157649069 | GenBank | AAI09319.1 | 1149 | ATP8A1 protein [Homo sapiens] |
| GI:157649069 | GenBank | EAW93003.1 | 1149 | ATPase, aminophospholipid transporter (APLT), Class I, type 8A, member 1, isoform CRA_a [Homo sapiens] |
| GI:17978471 | GenBank | EAW93004.1 | 1164 | ATPase, aminophospholipid transporter (APLT), Class I, type 8A, member 1, isoform CRA_b [Homo sapiens] |
| GI:17978471 | GenBank | ADS13346.1 | 1164 | Sequence 176 from patent US 7754856 |
| GI:17978471 | GenBank | AED82090.1 | 1164 | Sequence 827 from patent US 7919467 |
| GI:17978471 | GenBank | AEP61285.1 | 1164 | Sequence 379 from patent US 8026065 |
| GI:17978471 | SwissProt | Q9Y2Q0.1 | 1164 | RecName: Full=Phospholipid-transporting ATPase IA; AltName: Full=ATPase class I type 8A member 1; AltName: Full=Chromaffin granule ATPase II; AltName: Full=P4-ATPase flippase complex alpha subunit ATP8A1 [Homo sapiens] |
Related Sequences to LMP002334 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:157649069 | GenBank | AFE63455.1 | 1149 | probable phospholipid-transporting ATPase IA isoform b [Macaca mulatta] |
| GI:157649069 | GenBank | AFE76249.1 | 1149 | putative phospholipid-transporting ATPase IA isoform b [Macaca mulatta] |
| GI:157649069 | GenBank | JAA41104.1 | 1149 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 [Pan troglodytes] |
| GI:17978471 | RefSeq | XP_001150768.1 | 1164 | PREDICTED: phospholipid-transporting ATPase IA isoform X1 [Pan troglodytes] |
| GI:17978471 | RefSeq | XP_003258682.1 | 1164 | PREDICTED: probable phospholipid-transporting ATPase IA isoform 1 [Nomascus leucogenys] |
| GI:157649069 | RefSeq | NP_001252808.1 | 1149 | probable phospholipid-transporting ATPase IA [Macaca mulatta] |
| GI:17978471 | RefSeq | XP_003832277.1 | 1164 | PREDICTED: phospholipid-transporting ATPase IA isoform X1 [Pan paniscus] |
| GI:17978471 | RefSeq | XP_005554843.1 | 1164 | PREDICTED: probable phospholipid-transporting ATPase IA isoform X2 [Macaca fascicularis] |
| GI:157649069 | RefSeq | XP_005554844.1 | 1149 | PREDICTED: probable phospholipid-transporting ATPase IA isoform X3 [Macaca fascicularis] |
| GI:17978471 | RefSeq | XP_008015706.1 | 1164 | PREDICTED: probable phospholipid-transporting ATPase IA isoform X1 [Chlorocebus sabaeus] |
| GI:157649069 | RefSeq | XP_008015709.1 | 1149 | PREDICTED: probable phospholipid-transporting ATPase IA isoform X4 [Chlorocebus sabaeus] |
| GI:17978471 | RefSeq | XP_010362050.1 | 1164 | PREDICTED: phospholipid-transporting ATPase IA isoform X1 [Rhinopithecus roxellana] |