Gene/Proteome Database (LMPD)
Proteins
| phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha | |
|---|---|
| Refseq ID | NP_035213 |
| Protein GI | 145279206 |
| UniProt ID | Q61194 |
| mRNA ID | NM_011083 |
| Length | 1686 |
| RefSeq Status | VALIDATED |
| MAQISNNSEFKQCSSSHPEPIRTKDVNKAEALQMEAEALAKLQKDRQMTDSPRGFELSSSTRQRTQGFNKQDYDLMVFPELDSQKRAVDIDVEKLTQAELEKILLDDNFETRKPPALPVTPVLSPSFSTQLYLRPSGQRGQWPPGLCGPSTYTLPSTYPSAYSKQATFQNGFSPRMPTFPSTESVYLRLPGQSPYFSYPLTPATPFHPQGSLPVYRPLVSPDMAKLFEKIASTSEFLKNGKARTDLEIANSKASVCNLQISPKSEDINKFDWLDLDPLSKPKVDYVEVLEHEEEKKDPVLLAEDPWDAVLLEERSPSCHLERKVNGKSLSGATVTRSQSLIIRTAQFTKAQGQVSQKDPNGTSSLPTGSSLLQEFEVQNDEVAAFCQSIMKLKTKFPYTDHCTNPGYLLSPVTVQRNMCGENASVKVSIEIEGLQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQVDVGSYILKVCGQEEVLQNNHCLGSHEHIQNCRKWDTEIKLQLLTLSAMCQNLARTAEDDEAPVDLNKYLYQIEKPYKEVMTRHPVEELLDSYHYQVELALQTENQHRAVDQVIKAVRKICSALDGVETPSVTEAVKKLKRAVNLPRNKSADVTSLSGSDTRKNSTKGSLNPENPVQVSMDHLTTAIYDLLRLHANSSRCSTGCPRGSRNIKEAWTATEQLQFTVYAAHGISSNWVSNYEKYYLICSLSHNGKDLFKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLFGVLNQSSGSSPDSNKQRKGPEALGKVSLTLFDFKRFLTCGTKLLYLWTSSHTNSIPGAIPKKSYVMERIVLQVDFPSPAFDIIYTSPQIDRNIIQQDKLETLESDIKGKLLDIIHRDSSFGLSKEDKVFLWENRYYCLKHPNCLPKILASAPNWKWANLAKTYSLLHQWPPLCPLAALELLDAKFADQEVRSLAVSWMEAISDDELADLLPQFVQALKYEIYLNSSLVRFLLSRALGNIQIAHSLYWLLKDALHDTHFGSRYEHVLGALLSVGGKGLREELSKQMKLVQLLGGVAEKVRQASGSTRQVVLQKSMERVQSFFLRNKCRLPLKPSLVAKELNIKSCSFFSSNAMPLKVTMVNADPLGEEINVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFRCLSTGRDRGMVELVPASDTLRKIQVEYGVTGSFKDKPLAEWLRKYNPSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRFQLFVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATIFFTRLIESSLGSIATKFNFFIHNLAQLRFSGLPSNDEPILSFSPKTYSFRQDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGHLEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDEKAEGIARSAGAVPFSPTLGQIGGAVKLSVSYRNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDTHKTSKRKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGITLPLKDFNLSKETVKWYQLTAATYL | |
Gene Information
Entrez Gene ID
Gene Name
phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
| GO:0005942 | IBA:RefGenome | C | phosphatidylinositol 3-kinase complex |
| GO:0005886 | IBA:RefGenome | C | plasma membrane |
| GO:0016303 | IDA:MGI | F | 1-phosphatidylinositol-3-kinase activity |
| GO:0035005 | IBA:RefGenome | F | 1-phosphatidylinositol-4-phosphate 3-kinase activity |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0035091 | IEA:InterPro | F | phosphatidylinositol binding |
| GO:0006897 | IEA:Ensembl | P | endocytosis |
| GO:0071583 | IMP:MGI | P | negative regulation of zinc ion transmembrane transport |
| GO:0036092 | IDA:GOC | P | phosphatidylinositol-3-phosphate biosynthetic process |
| GO:0048015 | IEA:InterPro | P | phosphatidylinositol-mediated signaling |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR016024 | Armadillo-type fold |
| IPR000008 | C2 domain |
| IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
| IPR018936 | Phosphatidylinositol 3/4-kinase, conserved site |
| IPR002420 | Phosphatidylinositol 3-kinase, C2 domain |
| IPR000341 | Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain |
| IPR015433 | Phosphatidylinositol Kinase |
| IPR001263 | Phosphoinositide 3-kinase, accessory (PIK) domain |
| IPR001683 | Phox homologous domain |
| IPR011009 | Protein kinase-like domain |
| IPR029071 | Ubiquitin-related domain |
UniProt Annotations
Entry Information
Gene Name
phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
Protein Entry
P3C2A_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Caution | The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. |
| Similarity | Contains 1 C2 domain. |
| Similarity | Contains PI3K/PI4K domain. |
| Similarity | Contains PIK helical domain. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002337 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 145279206 | RefSeq | NP_035213 | 1686 | phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha |
Identical Sequences to LMP002337 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:145279206 | GenBank | AAI56427.1 | 1686 | Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide, partial [synthetic construct] |
| GI:145279206 | RefSeq | XP_006507503.1 | 1686 | PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [Mus musculus] |
Related Sequences to LMP002337 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:145279206 | GenBank | AAC52604.1 | 1658 | phosphoinositide 3-kinase [Mus musculus] |
| GI:145279206 | GenBank | AAE25823.1 | 1658 | Sequence 13 from patent US 5948664 |
| GI:145279206 | GenBank | AAE81960.1 | 1658 | Sequence 13 from patent US 6291220 |
| GI:145279206 | GenBank | AAE81975.1 | 1726 | Sequence 30 from patent US 6291220 |
| GI:145279206 | GenBank | EDL17105.1 | 1658 | phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide, isoform CRA_d [Mus musculus] |
| GI:145279206 | SwissProt | Q61194.2 | 1686 | RecName: Full=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Short=PI3K-C2-alpha; Short=PtdIns-3-kinase C2 subunit alpha; AltName: Full=Cpk-m; AltName: Full=Phosphoinositide 3-kinase-C2-alpha; AltName: Full=p170 [Mus musculus] |