Gene/Proteome Database (LMPD)
LMPD ID
LMP002343
Gene ID
Species
Homo sapiens (Human)
Gene Name
acyl-CoA thioesterase 9
Gene Symbol
Synonyms
ACATE2; MT-ACT48; MTACT48
Alternate Names
acyl-coenzyme A thioesterase 9, mitochondrial; acyl-CoA thioester hydrolase 9; mitochondrial Acyl-CoA Thioesterase; acyl-Coenzyme A thioesterase 2, mitochondrial
Chromosome
X
Map Location
Xp22.11
EC Number
3.1.2.-
Summary
The protein encoded by this gene is a mitochondrial acyl-CoA thioesterase of unknown function. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Orthologs
Proteins
| acyl-coenzyme A thioesterase 9, mitochondrial isoform a precursor | |
|---|---|
| Refseq ID | NP_001032248 |
| Protein GI | 81295407 |
| UniProt ID | Q9Y305 |
| mRNA ID | NM_001037171 |
| Length | 448 |
| RefSeq Status | REVIEWED |
| MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSPLSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQLHGDEFCPVLDATFVMVARDSENKGPAFVNPLIPESPEEEELFRQGELNKGRRIAFSSTSLLKMAPSAEERTTIHEMFLSTLDPKTISFRSRVLPSNAVWMENSKLKSLEICHPQERNIFNRIFGGFLMRKAYELAWATACSFGGSRPFVVAVDDIMFQKPVEVGSLLFLSSQVCFTQNNYIQVRVHSEVASLQEKQHTTTNVFHFTFMSEKEVPLVFPKTYGESMLYLDGQRHFNSMSGPATLRKDYLVEP | |
| transit_peptide: 1..21 calculated_mol_wt: 2226 peptide sequence: MRRAALRLCALGKGQLTPGRG mat_peptide: 22..439 product: acyl-coenzyme A thioesterase 9, mitochondrial isoform b calculated_mol_wt: 47694 peptide sequence: LTQGPQNPKKQGIFHIHEVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSPLSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQLHGDEFCPVLDATFVMVARDSENKGPAFVNPLIPESPEEEELFRQGELNKGRRIAFSSTSLLKMAPSAEERTTIHEMFLSTLDPKTISFRSRVLPSNAVWMENSKLKSLEICHPQERNIFNRIFGGFLMRKAYELAWATACSFGGSRPFVVAVDDIMFQKPVEVGSLLFLSSQVCFTQNNYIQVRVHSEVASLQEKQHTTTNVFHFTFMSEKEVPLVFPKTYGESMLYLDGQRHFNSMSGPATLRKDYLVEP transit_peptide: 1..21 calculated_mol_wt: 2226 peptide sequence: MRRAALRLCALGKGQLTPGRG mat_peptide: 22..448 product: acyl-coenzyme A thioesterase 9, mitochondrial isoform a calculated_mol_wt: 48643 peptide sequence: LTQGPQNPKKQGIFHIHEACSSIHVNHVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSPLSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQLHGDEFCPVLDATFVMVARDSENKGPAFVNPLIPESPEEEELFRQGELNKGRRIAFSSTSLLKMAPSAEERTTIHEMFLSTLDPKTISFRSRVLPSNAVWMENSKLKSLEICHPQERNIFNRIFGGFLMRKAYELAWATACSFGGSRPFVVAVDDIMFQKPVEVGSLLFLSSQVCFTQNNYIQVRVHSEVASLQEKQHTTTNVFHFTFMSEKEVPLVFPKTYGESMLYLDGQRHFNSMSGPATLRKDYLVEP | |
| acyl-coenzyme A thioesterase 9, mitochondrial isoform b precursor | |
|---|---|
| Refseq ID | NP_001028755 |
| Protein GI | 81295404 |
| UniProt ID | Q9Y305 |
| mRNA ID | NM_001033583 |
| Length | 439 |
| RefSeq Status | REVIEWED |
| MRRAALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHEVRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKYLTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMSPLSIVTALVDKIDMCKKSLSPEQDIKFSGHVSWVGKTSMEVKMQMFQLHGDEFCPVLDATFVMVARDSENKGPAFVNPLIPESPEEEELFRQGELNKGRRIAFSSTSLLKMAPSAEERTTIHEMFLSTLDPKTISFRSRVLPSNAVWMENSKLKSLEICHPQERNIFNRIFGGFLMRKAYELAWATACSFGGSRPFVVAVDDIMFQKPVEVGSLLFLSSQVCFTQNNYIQVRVHSEVASLQEKQHTTTNVFHFTFMSEKEVPLVFPKTYGESMLYLDGQRHFNSMSGPATLRKDYLVEP | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005739 | ISS:HGNC | C | mitochondrion |
| GO:0003986 | ISS:HGNC | F | acetyl-CoA hydrolase activity |
| GO:0052689 | IEA:UniProtKB-KW | F | carboxylic ester hydrolase activity |
| GO:0006637 | ISS:HGNC | P | acyl-CoA metabolic process |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-5148 | acyl-CoA hydrolysis |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9Y305-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q9Y305-2; Sequence=VSP_036419; Note=No experimental confirmation available.; Name=3; IsoId=Q9Y305-3; Sequence=VSP_036420; Note=No experimental confirmation available.; Name=4; IsoId=Q9Y305-4; Sequence=VSP_041093; |
| Function | Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs. |
| Similarity | Belongs to the acyl coenzyme A hydrolase family. |
| Subcellular Location | Mitochondrion . |
| Subunit | Interacts with NYAP1, NYAP2 and MYO16. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002343 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 81295407 | RefSeq | NP_001032248 | 448 | acyl-coenzyme A thioesterase 9, mitochondrial isoform a precursor |
| 81295404 | RefSeq | NP_001028755 | 439 | acyl-coenzyme A thioesterase 9, mitochondrial isoform b precursor |
Identical Sequences to LMP002343 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:81295407 | DBBJ | BAI46731.1 | 448 | acyl-CoA thioesterase 9, partial [synthetic construct] |
| GI:81295404 | GenBank | EAW98998.1 | 439 | acyl-CoA thioesterase 9, isoform CRA_b [Homo sapiens] |
| GI:81295404 | GenBank | AAI44361.1 | 439 | Acyl-CoA thioesterase 9 [Homo sapiens] |
| GI:81295404 | GenBank | AAI36672.1 | 439 | Acyl-CoA thioesterase 9 [Homo sapiens] |
| GI:81295404 | SwissProt | Q9Y305.2 | 439 | RecName: Full=Acyl-coenzyme A thioesterase 9, mitochondrial; Short=Acyl-CoA thioesterase 9; AltName: Full=Acyl-CoA thioester hydrolase 9; Flags: Precursor [Homo sapiens] |
Related Sequences to LMP002343 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:81295404 | DBBJ | BAI46731.1 | 448 | acyl-CoA thioesterase 9, partial [synthetic construct] |
| GI:81295404 | GenBank | JAA01659.1 | 439 | acyl-CoA thioesterase 9 [Pan troglodytes] |
| GI:81295407 | GenBank | JAA01660.1 | 448 | acyl-CoA thioesterase 9 [Pan troglodytes] |
| GI:81295404 | GenBank | JAA22305.1 | 439 | acyl-CoA thioesterase 9 [Pan troglodytes] |
| GI:81295407 | GenBank | JAA22306.1 | 448 | acyl-CoA thioesterase 9 [Pan troglodytes] |
| GI:81295404 | GenBank | JAA41754.1 | 439 | acyl-CoA thioesterase 9 [Pan troglodytes] |
| GI:81295407 | GenBank | JAA41755.1 | 448 | acyl-CoA thioesterase 9 [Pan troglodytes] |
| GI:81295407 | RefSeq | XP_520975.2 | 448 | PREDICTED: acyl-coenzyme A thioesterase 9, mitochondrial isoform X2 [Pan troglodytes] |
| GI:81295404 | RefSeq | XP_003317436.1 | 439 | PREDICTED: acyl-coenzyme A thioesterase 9, mitochondrial isoform X3 [Pan troglodytes] |
| GI:81295404 | RefSeq | XP_003819621.1 | 439 | PREDICTED: acyl-coenzyme A thioesterase 9, mitochondrial isoform X1 [Pan paniscus] |
| GI:81295407 | RefSeq | XP_005274527.1 | 451 | PREDICTED: acyl-coenzyme A thioesterase 9, mitochondrial isoform X1 [Homo sapiens] |
| GI:81295407 | RefSeq | XP_009437136.1 | 451 | PREDICTED: acyl-coenzyme A thioesterase 9, mitochondrial isoform X1 [Pan troglodytes] |