Gene/Proteome Database (LMPD)
LMPD ID
LMP002350
Gene ID
Species
Homo sapiens (Human)
Gene Name
apolipoprotein B receptor
Gene Symbol
Synonyms
APOB100R; APOB48R
Alternate Names
apolipoprotein B receptor; apoB-48R; apolipoprotein B48 receptor; apolipoprotein B-48 receptor; apolipoprotein B100 receptor; apolipoprotein B-100 receptor
Chromosome
16
Map Location
16p11
Summary
Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| apolipoprotein B receptor | |
|---|---|
| Refseq ID | NP_061160 |
| Protein GI | 340138932 |
| UniProt ID | Q0VD83 |
| mRNA ID | NM_018690 |
| Length | 1097 |
| RefSeq Status | REVIEWED |
| MDFLRLYLPGLHQALRGALDSLGTFVSYLLGDAVPTVEREAQAAEELGVVAVGKTGKIVEEEAQEDLEGLRGSQNEGAGRLRGPGDDRRHEVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSARGGAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQEEPPAPNPPEEELSAPEQRPLQLEEPLEPSPLRHDGTPVPARRRPLGHGFGLAHPGMMQELQARLGRPKPQ | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0042627 | IEA:UniProtKB-KW | C | chylomicron |
| GO:0034362 | IEA:UniProtKB-KW | C | low-density lipoprotein particle |
| GO:0016020 | IDA:UniProtKB | C | membrane |
| GO:0005886 | IEA:UniProtKB-KW | C | plasma membrane |
| GO:0034361 | IEA:UniProtKB-KW | C | very-low-density lipoprotein particle |
| GO:0030229 | IEA:Ensembl | F | very-low-density lipoprotein particle receptor activity |
| GO:0008203 | IEA:UniProtKB-KW | P | cholesterol metabolic process |
| GO:0006869 | IEA:UniProtKB-KW | P | lipid transport |
| GO:0006641 | IEA:Ensembl | P | triglyceride metabolic process |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR026158 | Apolipoprotein B receptor |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q0VD83-1; Sequence=Displayed; Name=2; IsoId=Q0VD83-2; Sequence=VSP_032733; Note=No experimental confirmation available.; Name=3; IsoId=Q0VD83-3; Sequence=VSP_032734; Note=No experimental confirmation available.; Name=4; IsoId=Q0VD83-4; Sequence=VSP_047051; Note=Gene prediction based on EST data.; |
| Function | Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG- VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. {ECO |
| Induction | Suppressed significantly by PPARA and PPARG in THP-1 and blood-borne monocyte-macrophages. Decreased after pitavastatin treatment in peripheral blood macrophages and remnant lipoprotein (RLP)-induced foam cell formation. {ECO |
| Ptm | There are 2 forms in macrophages, the membrane-binding proteins 200 kDa (MBP 200) and 235 kDa (MBP 235), that can be reduced into a single active ligand-binding species with intermediate mobility (MBP 200R). |
| Subcellular Location | Cell membrane {ECO |
| Subunit | Homodimer. |
| Tissue Specificity | Expressed in peripheral blood leukocytes > bone marrow = spleen > lymph node, and only faintly visible in appendix and thymus. Expressed in the brain, heart, kidney, liver, lung, pancreas, and placenta. Expressed primarily by reticuloendothelial cells: monocytes, macrophages, and endothelial cells. Expressed in atherosclerotic lesion foam cells. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002350 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 340138932 | RefSeq | NP_061160 | 1097 | apolipoprotein B receptor |
Identical Sequences to LMP002350 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|
Related Sequences to LMP002350 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:340138932 | GenBank | EAW52280.1 | 1097 | apolipoprotein B48 receptor, isoform CRA_c [Homo sapiens] |
| GI:340138932 | GenBank | ACP56804.1 | 1088 | Sequence 933 from patent US 7482117 |
| GI:340138932 | GenBank | ACP56805.1 | 1097 | Sequence 934 from patent US 7482117 |
| GI:340138932 | GenBank | ADS30401.1 | 1088 | Sequence 933 from patent US 7781168 |
| GI:340138932 | GenBank | ADS30402.1 | 1097 | Sequence 934 from patent US 7781168 |
| GI:340138932 | SwissProt | Q0VD83.2 | 1088 | RecName: Full=Apolipoprotein B receptor; AltName: Full=Apolipoprotein B-100 receptor; AltName: Full=Apolipoprotein B-48 receptor; Short=Apolipoprotein B48 receptor; Short=apoB-48R [Homo sapiens] |