Gene/Proteome Database (LMPD)

LMPD ID
LMP002355
Gene ID
103968
Species
Mus musculus (Mouse)
Gene Name
perilipin 1
Gene Symbol
Plin1
Synonyms
6030432J05Rik; Peri; Plin
Alternate Names
perilipin-1; perilipin A; perilipin B; lipid droplet-associated protein
Chromosome
7
Map Location
7 D3|7

Proteins

perilipin-1
Refseq ID NP_783571
Protein GI 164698408
UniProt ID Q8CGN5
mRNA ID NM_175640
Length 517
RefSeq Status VALIDATED
MSMNKGPTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYNSTKEAHPLVASVCNAYEKGVQGASNLAAWSMEPVVRRLSTQFTAANELACRGLDHLEEKIPALQYPPEKIASELKGTISTRLRSARNSISVPIASTSDKVLGATLAGCELALGMAKETAEYAANTRVGRLASGGADLALGSIEKVVEFLLPPDKESAPSSGRQRTQKAPKAKPSLVRRVSTLANTLSRHTMQTTAWALKQGHSLAMWIPGVAPLSSLAQWGASAAMQVVSRRQSEVRVPWLHNLAASQDESHDDQTDTEGEETDDEEEEEESEAEENVLREVTALPNPRGLLGGVVHTVQNTLRNTISAVTWAPAAVLGTVGRILHLTPAQAVSSTKGRAMSLSDALKGVTDNVVDTVVHYVPLPRLSLMEPESEFRDIDNPSAEAERKGSGARPASPESTPRPGQPRGSLRSVRGLSAPSCPGLDDKTEASARPGFLAMPREKPARRVSDSFFRPSVMEPILGRAQYSQLRKKS
perilipin-1
Refseq ID NP_001106942
Protein GI 164698413
UniProt ID Q8CGN5
mRNA ID NM_001113471
Length 517
RefSeq Status VALIDATED
Protein sequence is identical to GI:164698408 (mRNA isoform)

Gene Information

Entrez Gene ID
103968
Gene Name
perilipin 1
Gene Symbol
Plin1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:MGI C cytosol
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0005811 IDA:MGI C lipid particle
GO:0016042 IMP:MGI P lipid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu03320 PPAR signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5893263 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis

Domain Information

InterPro Annotations

Accession Description
IPR004279 Perilipin

UniProt Annotations

Entry Information

Gene Name
perilipin 1
Protein Entry
PLIN1_MOUSE
UniProt ID
Q8CGN5
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Peri A; IsoId=Q8CGN5-1; Sequence=Displayed; Name=2; Synonyms=Peri B; IsoId=Q8CGN5-2; Sequence=VSP_038208, VSP_038209; Name=3; Synonyms=Peri C; IsoId=Q8CGN5-3; Sequence=VSP_038206, VSP_038207; Name=4; Synonyms=Peri D; IsoId=Q8CGN5-4; Sequence=VSP_038204, VSP_038205;
Function Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone- sensitive lipase (HSL). Its absence may result in leanness (By similarity). Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. {ECO:0000250, ECO:0000269|PubMed:23481402}.
Ptm Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet (By similarity). {ECO:0000250}.
Similarity Belongs to the perilipin family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum {ECO:0000250}. Lipid droplet {ECO:0000269|PubMed:23481402}. Note=Lipid droplet surface- associated.
Subunit Interacts with ABHD5. Interacts with CIDEC. {ECO:0000269|PubMed:15292255, ECO:0000269|PubMed:23481402}.
Web Resource Name=Protein Spotlight; Note=Fat, wonderful fat - Issue 10 of May 2001; URL="http://web.expasy.org/spotlight/back_issues/010";

Identical and Related Proteins

Unique RefSeq proteins for LMP002355 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
164698408 RefSeq NP_783571 517 perilipin-1

Identical Sequences to LMP002355 proteins

Reference Database Accession Length Protein Name
GI:164698408 GenBank AAH96685.1 517 Perilipin [Mus musculus]
GI:164698408 GenBank EDL07055.1 517 perilipin, isoform CRA_f [Mus musculus]
GI:164698408 RefSeq NP_001106942.1 517 perilipin-1 [Mus musculus]
GI:164698408 SwissProt Q8CGN5.2 517 RecName: Full=Perilipin-1; AltName: Full=Lipid droplet-associated protein; AltName: Full=Perilipin A [Mus musculus]

Related Sequences to LMP002355 proteins

Reference Database Accession Length Protein Name
GI:164698408 DBBJ BAC27409.1 517 unnamed protein product [Mus musculus]
GI:164698408 GenBank AAN77870.1 517 lipid droplet-associated protein perilipin [Mus musculus]
GI:164698408 GenBank EDL07054.1 527 perilipin, isoform CRA_e, partial [Mus musculus]
GI:164698408 GenBank EDM08591.1 518 perilipin, isoform CRA_b [Rattus norvegicus]
GI:164698408 GenBank EDM08592.1 518 perilipin, isoform CRA_b [Rattus norvegicus]
GI:164698408 RefSeq XP_008757721.1 518 PREDICTED: perilipin-1 isoform X1 [Rattus norvegicus]