Gene/Proteome Database (LMPD)

LMPD ID
LMP002357
Gene ID
11677
Species
Mus musculus (Mouse)
Gene Name
aldo-keto reductase family 1, member B3 (aldose reductase)
Gene Symbol
Akr1b3
Synonyms
ALR2; AR; Ahr-1; Ahr1; Akr1b1; Aldor1; Aldr1
Alternate Names
aldose reductase; aldehyde reductase 1; aldo-keto reductase family 1, member B1 (aldose reductase)
Chromosome
6
Map Location
6 B1|6 14.87 cM
EC Number
1.1.1.21

Proteins

aldose reductase
Refseq ID NP_033788
Protein GI 160707894
UniProt ID P45376
mRNA ID NM_009658
Length 316
RefSeq Status VALIDATED
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDLGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDKSMVKGAFQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKTIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPVRIAENLKVFDFEVSSEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV

Gene Information

Entrez Gene ID
11677
Gene Name
aldo-keto reductase family 1, member B3 (aldose reductase)
Gene Symbol
Akr1b3
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005634 IEA:Ensembl C nucleus
GO:0004032 IDA:MGI F alditol:NADP+ 1-oxidoreductase activity
GO:0043795 IEA:Ensembl F glyceraldehyde oxidoreductase activity
GO:0044597 IEA:Ensembl P daunorubicin metabolic process
GO:0044598 IEA:Ensembl P doxorubicin metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00561 Glycerolipid metabolism
mmu00040 Pentose and glucuronate interconversions

REACTOME Pathway Links

REACTOME Pathway ID Description
5893449 Pregnenolone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001395 Aldo/keto reductase
IPR020471 Aldo/keto reductase subgroup
IPR018170 Aldo/keto reductase, conserved site
IPR023210 NADP-dependent oxidoreductase domain

UniProt Annotations

Entry Information

Gene Name
aldo-keto reductase family 1, member B3 (aldose reductase)
Protein Entry
ALDR_MOUSE
UniProt ID
P45376
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Alditol + NAD(P)(+) = aldose + NAD(P)H.
Function Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Similarity Belongs to the aldo/keto reductase family. {ECO:0000305}.
Subcellular Location Cytoplasm.
Subunit Monomer.
Tissue Specificity Abundant in the testis, skeletal muscle and kidney.

Identical and Related Proteins

Unique RefSeq proteins for LMP002357 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
160707894 RefSeq NP_033788 316 aldose reductase

Identical Sequences to LMP002357 proteins

Reference Database Accession Length Protein Name
GI:160707894 DBBJ BAE32272.1 316 unnamed protein product [Mus musculus]
GI:160707894 DBBJ BAE29130.1 316 unnamed protein product [Mus musculus]
GI:160707894 DBBJ BAE29373.1 316 unnamed protein product [Mus musculus]
GI:160707894 DBBJ BAE37874.1 316 unnamed protein product [Mus musculus]
GI:160707894 DBBJ BAE23933.1 316 unnamed protein product [Mus musculus]
GI:160707894 GenBank EDL13695.1 316 mCG6067, isoform CRA_b [Mus musculus]

Related Sequences to LMP002357 proteins

Reference Database Accession Length Protein Name
GI:160707894 DBBJ BAA06980.1 316 aldose reductase [Mus musculus]
GI:160707894 GenBank AAC13358.1 316 aldose reductase [Mus musculus]
GI:160707894 GenBank AAH04725.1 316 Aldo-keto reductase family 1, member B3 (aldose reductase) [Mus musculus]
GI:160707894 GenBank AAH21655.1 316 Aldo-keto reductase family 1, member B3 (aldose reductase) [Mus musculus]
GI:160707894 GenBank AAH85310.1 316 Aldo-keto reductase family 1, member B3 (aldose reductase) [Mus musculus]
GI:160707894 PRF - 316 aldo-ketoreductase [Mus musculus]