Gene/Proteome Database (LMPD)

LMPD ID
LMP002362
Gene ID
13478
Species
Mus musculus (Mouse)
Gene Name
dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
Gene Symbol
Dpagt1
Synonyms
AU021132; Dpagt2; GPT; Gnpta
Alternate Names
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; G1PT; glcNAc-1-P transferase; N-acetylglucosamine-1-phosphate transferase; dolichyl-phosphate alpha-N-acetylglucosaminephosphotransferase 2; UDP-N-acetylglucosamine lysosomal enzyme N-acetylglucosamine phosphotransferase
Chromosome
9
Map Location
9 A5.2|9 24.84 cM
EC Number
2.7.8.15

Proteins

UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
Refseq ID NP_031901
Protein GI 31982409
UniProt ID P42867
mRNA ID NM_007875
Length 410
RefSeq Status PROVISIONAL
MWAFPELPLPLPLLVNLIGSLLGFVATVTLIPAFRSHFIAARLCGQDLNKLSQQQIPESQGVISGAVFLIILFCFIPFPFLNCFVEEQCKAFPHHEFVALIGALLAICCMIFLGFADDVLNLRWRHKLLLPTAASLPLLMVYFTNFGNTTIVVPKPFRWILGLHLDLGILYYVYMGLLAVFCTNAINILAGINGLEAGQSLVISASIIVFNLVELEGDYRDDHIFSLYFMIPFFFTTLGLLYHNWYPSRVFVGDTFCYFAGMTFAVVGILGHFSKTMLLFFMPQVFNFLYSLPQLFHIIPCPRHRMPRLNAKTGKLEMSYSKFKTKNLSFLGTFILKVAENLRLVTVHQGESEDGAFTECNNMTLINLLLKVFGPIHERNLTLLLLLLQVLSSAATFSIRYQLVRLFYDV

Gene Information

Entrez Gene ID
13478
Gene Name
dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
Gene Symbol
Dpagt1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:MGI C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0003975 IDA:MGI F UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
GO:0003976 ISS:MGI F UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
GO:0008963 IEA:InterPro F phospho-N-acetylmuramoyl-pentapeptide-transferase activity
GO:0016757 IEA:UniProtKB-KW F transferase activity, transferring glycosyl groups
GO:0006047 IEA:Ensembl P UDP-N-acetylglucosamine metabolic process
GO:0019408 IEA:Ensembl P dolichol biosynthetic process
GO:0006488 TAS:MGI P dolichol-linked oligosaccharide biosynthetic process
GO:0006487 IEA:Ensembl P protein N-linked glycosylation

KEGG Pathway Links

KEGG Pathway ID Description
mmu01100 Metabolic pathways
ko00510 N-Glycan biosynthesis
mmu00510 N-Glycan biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR000715 Glycosyl transferase, family 4

UniProt Annotations

Entry Information

Gene Name
dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
Protein Entry
GPT_MOUSE
UniProt ID
P42867
Species
Mouse

Comments

Comment Type Description
Catalytic Activity UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.
Developmental Stage Highest activity is during the mid-phase of lactation.
Disruption Phenotype Mice die 4 to 5 days post-fertilization, just after implantation, suggesting that protein function and N- glycosylation are essential in early embryogenesis. {ECO:0000269|PubMed:10536042}.
Enzyme Regulation Enzyme activity is stimulated by phosphatidylglycerol and mannosylphosphoryldolichol and inhibited by tunicamycin.
Function Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides.
Pathway Protein modification; protein glycosylation.
Rna Editing Modified_positions=74 {ECO:0000269|PubMed:8043075}; Note=Partially edited.;
Similarity Belongs to the glycosyltransferase 4 family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP002362 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31982409 RefSeq NP_031901 410 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

Identical Sequences to LMP002362 proteins

Reference Database Accession Length Protein Name
GI:31982409 GenBank AAH10474.1 410 Dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) [Mus musculus]
GI:31982409 GenBank EDL25578.1 410 dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase), isoform CRA_b [Mus musculus]
GI:31982409 SwissProt P42867.2 410 RecName: Full=UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; AltName: Full=GlcNAc-1-P transferase; Short=G1PT; Short=GPT; AltName: Full=N-acetylglucosamine-1-phosphate transferase [Mus musculus]

Related Sequences to LMP002362 proteins

Reference Database Accession Length Protein Name
GI:31982409 EMBL CAA46553.1 410 GlcNAc-1-P transferase [Mus musculus]
GI:31982409 GenBank AAH63184.1 410 Dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) [Rattus norvegicus]
GI:31982409 GenBank EDL95292.1 410 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase), isoform CRA_a [Rattus norvegicus]
GI:31982409 RefSeq NP_955420.1 410 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase [Rattus norvegicus]
GI:31982409 RefSeq XP_005069480.1 408 PREDICTED: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase [Mesocricetus auratus]
GI:31982409 RefSeq XP_005347232.1 408 PREDICTED: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase [Microtus ochrogaster]